Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CBL | 867 | Cbl proto-oncogene, E3 ubiquitin protein ligase | 11 | RNF55, c-Cbl |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24525700 | 2014 | Cell line : DLD 1, RKO, LoVo, SW620, HT 29 Source : Fundacion Jimenez Diaz Biobank (BFJD, Madrid). Sample Type : - No. of Sample : 22 Stage : TNM stage I,II,III,IV | - | Up-regulation | - | CRC cases showed c-Cbl
overexpression in the tumor samples compared to their paired
normal colonic mucosa. |
| 25675408 | 2014 | Cell line : Caco 2
Source : - Sample Type : - No. of Sample : - Stage : TNM stage I,II,III,IV | Western Blotting, tissue microarrays , immunohistochemistry,Co-immunoprecipitation | Up-regulation | - | MUC1/CIN85/Cbl complex appears to contribute to promotion and progression of colon cancer and thus increased expression of MUC1, CIN85 and Cbl in early stage colon cancer might be predictive of poor prognosis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | RING-type (C3HC4) zinc fingers |
| Description | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012] |
| Chromosome | 11 |
| Location | 11q23.3 |
| Start | 119076986 |
| End | 119178859 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 101874 |
| OMIM ID | 165360 |
| HGNC ID | HGNC:1541 |
| Unigene ID | Hs.504096 |
| Ensembl ID | ENSG00000110395 |
| PharmGKB ID | PA26115 |
mRNA Information
| mRNA ID | XM_011542771.1 |
|---|---|
| Exon | complement(<1..11) | mRNA Sequence | Download Select all |
| Length | 1020 |
Protein Information
| Protein ID | XP_011541073.1 |
|---|---|
| Protein Name | Cbl proto-oncogene, E3 ubiquitin protein ligase |
| Molecular Wt. (Da) | 23099 |
| Protein Sequence | Download Select all |
| Length | 202 |
| Uniprot ID | P15172 |
| Ensembl Protein ID | ENSP00000250003 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 669 |
| Y | Phosphorylation | 674 |
| Y | Phosphorylation | 700 |
| Y | Phosphorylation | 731 |
| Y | Phosphorylation | 774 |
| Y | Phosphorylation | 731 |
| Y | Phosphorylation | 731 |
| Y | Phosphorylation | 371 |
| S | Phosphorylation | 619 |
| S | Phosphorylation | 623 |
| S | Phosphorylation | 642 |
| S | Phosphorylation | 639 |
| S | Phosphorylation | 667 |
| S | Phosphorylation | 675 |
| Y | Phosphorylation | 731 |
| Y | Phosphorylation | 552;- |
| S | Phosphorylation | 452 |
| S | Phosphorylation | 900 |
| Y | Phosphorylation | 455 |
| K | Acetylation | 197 |
| Y | Phosphorylation | 370 |
| Y | Phosphorylation | 454 |
| Y | Phosphorylation | 551 |
| Y | Phosphorylation | 699 |
| S | Phosphorylation | 483 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 921 | CD5 | 1078 | NP_055022.2 | in vitro | 9603468 |
| 930 | CD19 | 113 | NP_001761.3 | in vivo | 9178909 |
| 1398 | CRK | 1267 | NP_058431.2 | in vitro;in vivo | 86 214 838 662 998 |
| 1436 | CSF1R | 1269 | NP_005202.2 | in vitro;in vivo;yeast 2-hybrid | 11847211 |
| 2268 | FGR | 1288 | NP_005239.1 | in vivo | 124 352 677 721 825 |
| 2533 | FYB | 4107 | NP_001456.3 | in vivo | 16503409 |
| 3791 | KDR | 1867 | NP_002244.1 | in vitro | 12649282 |
| 3875 | KRT18 | 1020 | NP_000215.1 | in vivo;yeast 2-hybrid | 9367879 |
| 3932 | LCK | 1080 | NP_005347.3 | in vivo | 91 789 091 190 443 300 000 000 |
| 4058 | LTK | 1052 | NP_002335.2 | in vitro;in vivo | 9223670 |
| 4067 | LYN | 1301 | NP_002341.1 | in vivo;yeast 2-hybrid | 121 496 558 621 719 |
| 4233 | MET | 1280 | NP_001120972.1 | in vitro;in vivo;yeast 2-hybrid | 1 189 409 618 273 060 |
| 5156 | PDGFRA | 1429 | NP_006197.1 | in vivo | 9234717 |
| 5159 | PDGFRB | 1423 | NP_002600.1 | in vitro | 10514377 |
| 5295 | PIK3R1 | 1381 | NP_852664.1 | in vitro;in vivo | 11 133 830 862 171 900 000 000 000 000 000 000 000 000 000 |
| 5979 | RET | 1266 | NP_066124.1 | in vivo | 12727845 |
| 6776 | STAT5A | 3301 | NP_003143.2 | in vivo | 12193575 |
| 6777 | STAT5B | 5037 | NP_036580.2 | in vivo | 12193575 |
| 7189 | TRAF6 | 3833 | NP_665802.1 | in vivo | 11406619 |
| 7409 | VAV1 | 1284 | NP_005419.2 | in vitro;in vivo | 920 044 011 133 830 |
| 7462 | LAT2 | 9304 | NP_071323.1 | in vitro;in vivo | 12486104 |
| 7529 | YWHAB | 3184 | NP_003395.1 | in vitro;yeast 2-hybrid | 9367879 |
| 7534 | YWHAZ | 3183 | NP_003397.1 | yeast 2-hybrid | 9367879 |
| 8792 | TNFRSF11A | 4609 | NP_003830.1 | in vitro;in vivo | 11406619 |
| 10603 | SH2B2 | 16097 | NP_066189.3 | in vitro;in vivo | 119 974 971 503 129 000 000 000 000 000 000 000 000 |
| 10971 | YWHAQ | 886 | NP_006817.1 | in vitro;in vivo | 110 240 378 663 231 |
| 23048 | FNBP1 | 10446 | NP_055848.1 | in vitro;in vivo | 18273061 |
| 26578 | OSTF1 | 17808 | NP_036515.4 | in vitro;yeast 2-hybrid | 15135048 |
| 27040 | LAT | 3832 | NP_001014989.2 | in vivo | 8798643 |
| 50807 | ASAP1 | 5809 | NP_060952.2 | in vitro;in vivo | 17255943 |
| 83737 | ITCH | 7565 | Q96J02 | in vivo | 12226085 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bacterial invasion of epithelial cells | hsa05100 |
| Chronic myeloid leukemia | hsa05220 |
| Endocytosis | hsa04144 |
| ErbB signaling pathway | hsa04012 |
| Insulin signaling pathway | hsa04910 |
| Pathways in cancer | hsa05200 |
| Proteoglycans in cancer | hsa05205 |
| T cell receptor signaling pathway | hsa04660 |
| Ubiquitin mediated proteolysis | hsa04120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09920 | 256-352 | SH2_Cbl-b_TKB |
| cl15255 | 256-352 | SH2 superfamily |
| cd14393 | 857-896 | UBA_c-Cbl |
| cl21463 | 857-896 | UBA_like_SF superfamily |
| cd00162 | 381-423 | RING |
| cl17238 | 381-423 | RING superfamily |
| pfam02262 | 49-176 | Cbl_N |
| cl03506 | 49-176 | Cbl_N superfamily |
| pfam02762 | 264-349 | Cbl_N3 |
| pfam02761 | 178-262 | Cbl_N2 |
| cl03701 | 178-262 | Cbl_N2 superfamily |
| cd14318 | 857-896 | UBA_Cbl_like |
| pfam00097 | 381-419 | zf-C3HC4 |
| cd14392 | 857-896 | UBA_Cbl-b |
| smart00184 | 381-419 | RING |
| pfam13920 | 379-426 | zf-C3HC4_3 |
| pfam13923 | 381-419 | zf-C3HC4_2 |
| smart00165 | 857-892 | UBA |
| pfam13639 | 381-420 | zf-RING_2 |
| pfam00627 | 861-892 | UBA |
| pfam14634 | 381-420 | zf-RING_5 |
| cd00173 | 266-336 | SH2 |
| pfam15227 | 381-419 | zf-C3HC4_4 |
| pfam14447 | 379-419 | Prok-RING_4 |
| PHA03247 | 480-810 | PHA03247 |
| PHA03247 | 476-801 | PHA03247 |
| COG5574 | 381-420 | PEX10 |
| PHA02929 | 381-420 | PHA02929 |
| COG5243 | 363-434 | HRD1 |
| COG5236 | 379-422 | COG5236 |
| PHA03247 | 480-717 | PHA03247 |
Ontology Information
| HPRD ID | 1233 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.