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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20849597 | 2010 | Cell line : - Source : Surgical Clinic of the General University Hospital of Patras, Greece. Sample Type : CRC Tumor and normal tissue No. of Sample : 34 Stage : Stage A-D. | RT-PCR,zymography and western blotting | Up-regulation | - | Hyal-1 and Hyal-2 were overexpressed in cancerous samples, especially in advanced stages of cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010 |
| Chromosome | 3 |
| Location | 3p21.3 |
| Start | 50355221 |
| End | 50360281 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5061 |
| OMIM ID | 603551 |
| HGNC ID | HGNC:5321 |
| Unigene ID | Hs.76873 |
| Ensembl ID | ENSG00000068001 |
| PharmGKB ID | PA29572 |
Protein Information
| Protein ID | NP_003764.3 |
|---|---|
| Protein Name | hyaluronoglucosaminidase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 473 |
| Uniprot ID | Q9UBX7 |
| Ensembl Protein ID | ENSP00000324269 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4486 | MST1R | 2545 | NP_002438.2 | in vivo | 12676986 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Glycosaminoglycan degradation | hsa00531 |
| Metabolic pathways | hsa01100 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01630 | 29-363 | Glyco_hydro_56 |
| cl03288 | 29-363 | Glyco_hydro_56 superfamily |
Ontology Information
| HPRD ID | 3811 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.