Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TNFSF13 | 8741 | tumor necrosis factor (ligand) superfamily, member 13 | 17 | APRIL, CD256 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20003335 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, Immunohistochemistry | Up-regulation | - | Identified APRIL, a novel chemo-resistance biomarker with independent predictive impact in 5FU-treated CRC patients, that may represent a target for novel therapeutics. APRIL/TNFSF13 mRNA was significantly upregulated following 5FU based concurrent chemo-radiotherapy and in 5FU resistant colorectal adenocarcinoma cell lines but not in radiotherapy alone treated colorectal adenocarcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor (ligand) superfamily, "CD molecules" |
| Description | The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |
| Chromosome | 17 |
| Location | 17p13.1 |
| Start | 7558292 |
| End | 7561608 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 3317 |
| OMIM ID | 604472 |
| HGNC ID | HGNC:11928 |
| Unigene ID | Hs.54673 |
| Ensembl ID | ENSG00000161955 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_172089.3 |
|---|---|
| Exon | join(<1333..1411,1555..1602,1758..1876,2059..2197, 2433..3317) | mRNA Sequence | Download Select all |
| Length | 2212 |
CDS Information
| Location | join(<1333..1411,1555..1602,1758..1876,2059..2197, 2433..2542) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS11108.1 |
Protein Information
| Protein ID | NP_001185552.1 |
|---|---|
| Protein Name | tumor necrosis factor (ligand) superfamily, member 13 |
| Molecular Wt. (Da) | 24020 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | Q13418 |
| Ensembl Protein ID | ENSP00000299421 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 101 |
| R | Proteolytic Cleavage | 101 |
| R | Proteolytic Cleavage | 101 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 355 | FAS | 609 | NP_000034.1 | in vitro | 10706119 |
| 608 | TNFRSF17 | 144 | NP_001183.2 | in vitro | 10973284 |
| 4982 | TNFRSF11B | 4032 | NP_002537.3 | in vitro | 10706119 |
| 6383 | SDC2 | 803 | NP_002989.2 | in vivo | 15846369 |
| 7132 | TNFRSF1A | 1861 | NP_001056.1 | in vitro | 10706119 |
| 8764 | TNFRSF14 | 4122 | NP_003811.2 | in vitro | 10706119 |
| 10673 | TNFSF13B | 4914 | NP_006564.1 | in vitro | 12370363 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Intestinal immune network for IgA production | hsa04672 |
| Rheumatoid arthritis | hsa05323 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00184 | 117-248 | TNF |
| cl00147 | 117-248 | TNF superfamily |
| pfam00229 | 139-250 | TNF |
| smart00207 | 146-227 | TNF |
Ontology Information
| HPRD ID | 5103 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.