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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21190186 | 2012 | Cell line : - Source : Department of Surgery (Centre Hospitalier Universitaire of Nantes) were snap frozen in the Biobank, then included in the study. Sample Type : CRC tumor and normal tissues No. of Sample : 94 Stage : TNM Stage I-III | MSI analysis,Immunohistochemistry,real time RT-PCR ,ADAM15 promoter methylation | Down-regulation | - | Thirty-six percent of colorectal carcinomas displayed a reduced expression of ADAM15 in cancer cells |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidase domain containing |
| Description | The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1q21.3 |
| Start | 155023748 |
| End | 155035252 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11505 |
| OMIM ID | 605548 |
| HGNC ID | HGNC:193 |
| Unigene ID | Hs.312098 |
| Ensembl ID | ENSG00000143537 |
| PharmGKB ID | PA24510 |
Protein Information
| Protein ID | NP_001248393.1 |
|---|---|
| Protein Name | ADAM metallopeptidase domain 15 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 863 |
| Uniprot ID | Q9BTC0 |
| Ensembl Protein ID | ENSP00000266070 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro;in vivo | 11741929 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 1 174 192 916 374 500 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro | 1 174 192 916 374 500 |
| 3055 | HCK | 796 | NP_002101.2 | in vitro | 1 174 192 916 374 500 |
| 3932 | LCK | 1080 | NP_005347.3 | in vitro;in vivo | 1 174 192 916 374 500 |
| 4067 | LYN | 1301 | NP_002341.1 | in vitro | 16374509 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro | 16374509 |
| 4867 | NPHP1 | 9524 | NP_000263.2 | in vitro | 16374509 |
| 6456 | SH3GL2 | 5125 | NP_003017.1 | in vitro | 1 053 137 916 374 500 |
| 6714 | SRC | 1819 | NP_005408.1 | in vitro;in vivo | 1 174 192 916 374 500 |
| 7525 | YES1 | 1285 | NP_005424.1 | in vitro | 16374509 |
| 8470 | SORBS2 | 12473 | NP_066547.1 | in vitro | 16374509 |
| 8874 | ARHGEF7 | 5688 | NP_001106983.1 | in vitro | 16374509 |
| 9459 | ARHGEF6 | 2226 | NP_004831.1 | in vitro | 16374509 |
| 9644 | SH3PXD2A | 10228 | NP_055446.2 | in vitro | 16374509 |
| 10174 | SORBS3 | 11535 | NP_005766.3 | in vitro | 16374509 |
| 10580 | SORBS1 | 5587 | NP_001030126.1 | in vitro | 16374509 |
| 57630 | SH3RF1 | 15335 | NP_065921.2 | in vitro | 16374509 |
| 257364 | SNX33 | 11331 | NP_695003.1 | in vitro;in vivo | 16374509 |
| 344558 | SH3RF3 | 19427 | NP_001092759.1 | in vitro | 16374509 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04269 | 213-411 | ZnMc_adamalysin_II_like |
| cl00064 | 213-411 | ZnMc superfamily |
| smart00608 | 508-649 | ACR |
| cl15456 | 508-649 | ADAM_CR superfamily |
| smart00050 | 430-504 | DISIN |
| cl10507 | 430-504 | Disintegrin superfamily |
| pfam00200 | 430-504 | Disintegrin |
| cd04267 | 213-402 | ZnMc_ADAM_like |
| pfam08516 | 508-623 | ADAM_CR |
| pfam01562 | 42-167 | Pep_M12B_propep |
| cl03265 | 42-167 | Pep_M12B_propep superfamily |
| cd04273 | 213-411 | ZnMc_ADAMTS_like |
| pfam13582 | 231-359 | Reprolysin_3 |
| pfam13688 | 212-391 | Reprolysin_5 |
| cd00203 | 213-402 | ZnMc |
| cd04272 | 214-396 | ZnMc_salivary_gland_MPs |
| cd04270 | 301-413 | ZnMc_TACE_like |
| pfam13583 | 213-394 | Reprolysin_4 |
| pfam13574 | 307-396 | Reprolysin_2 |
| cd04271 | 310-382 | ZnMc_ADAM_fungal |
| cd04268 | 278-358 | ZnMc_MMP_like |
| cd04278 | 332-358 | ZnMc_MMP |
| pfam01421 | 213-411 | Reprolysin |
| pfam00413 | 330-359 | Peptidase_M10 |
Ontology Information
| HPRD ID | 17902 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.