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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21850381 | 2011 | Cell line : RKO, HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Beadarray and in vitro chemosensitivity assay,cell viability assays | Hypomethylation | - | Two novel genes, GALR2 and ALX4, have been identified as chemosensitive methylation candidates to bevacizumab and cetuximab regimens, respectively. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Galanin receptors |
| Description | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q25.3 |
| Start | 74070892 |
| End | 74073573 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2682 |
| OMIM ID | 603691 |
| HGNC ID | HGNC:4133 |
| Unigene ID | Hs.666366 |
| Ensembl ID | ENSG00000182687 |
| PharmGKB ID | PA28546 |
Protein Information
| Protein ID | NP_003848.1 |
|---|---|
| Protein Name | galanin receptor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 387 |
| Uniprot ID | P78410 |
| Ensembl Protein ID | ENSP00000348751 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 292;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2776 | GNAQ | 2998 | NP_002063.2 | in vivo | 9685625 |
| 51083 | GAL | 658 | NP_057057.2 | in vivo | 9685625 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 36-306 | 7TM_GPCR_Srsx |
| cl21561 | 36-306 | 7tm_4 superfamily |
| pfam10324 | 38-165 | 7TM_GPCR_Srw |
| pfam00001 | 58-292 | 7tm_1 |
| PHA03087 | 27-304 | PHA03087 |
| PHA02638 | 28-300 | PHA02638 |
| PHA02834 | 28-306 | PHA02834 |
| PHA03235 | 34-387 | PHA03235 |
Ontology Information
| HPRD ID | 5922 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Protein tyrosine phosphatase activity (GO:0004725) |
| Biological Process | Cell motility (GO:0006928); Cell proliferation (GO:0008283) |
Drug Information
No matching records could be found.