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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25198900 | 2014 | Cell line : - Source : Department of Pathology at the National Cancer Research Centre (NCRC), Istituto Tumori �Giovanni Paolo II� of Bari, Italy. Sample Type : CRC Tumor and adjescent tissue No. of Sample : 58 Stage : TNM stage IV | Immunohistochemistry | Up-regulation | - | High expression of CES2, ABCG2, TS and Topo-I was observed in 55%, 56%, 38% and 49% of patients, respectively. There was a significant association between high TS and high ABCG2 expression. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Carboxylesterases |
| Description | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] |
| Chromosome | 16 |
| Location | 16q22.1 |
| Start | 66968347 |
| End | 66978999 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 10653 |
| OMIM ID | 605278 |
| HGNC ID | HGNC:1864 |
| Unigene ID | Hs.282975 |
| Ensembl ID | ENSG00000172831 |
| PharmGKB ID | PA377 |
Protein Information
| Protein ID | NP_003860.2 |
|---|---|
| Protein Name | carboxylesterase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 559 |
| Uniprot ID | Q9HC96 |
| Ensembl Protein ID | ENSP00000270361 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Drug metabolism - other enzymes | hsa00983 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00312 | 35-524 | Esterase_lipase |
| cl21494 | 35-524 | Esterase_lipase superfamily |
| pfam00135 | 30-538 | COesterase |
| COG2272 | 30-539 | PnbA |
| pfam00326 | 164-257 | Peptidase_S9 |
| pfam03280 | 509-559 | Lipase_chap |
| cl19941 | 509-559 | Lipase_chap superfamily |
| COG0657 | 128-231 | Aes |
| pfam07859 | 143-231 | Abhydrolase_3 |
| COG1506 | 128-232 | DAP2 |
| pfam00756 | 126-234 | Esterase |
Ontology Information
| HPRD ID | 9753 |
|---|---|
| Molecular Class | Enzyme: Esterase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O00748 | DB00688 | Mycophenolate mofetil | SmallMoleculeDrug |
| O00748 | DB00762 | Irinotecan | SmallMoleculeDrug |
| O00748 | DB06209 | Prasugrel | SmallMoleculeDrug |
| O00748 | DB06695 | Dabigatran etexilate | SmallMoleculeDrug |