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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25351619 | 2015 | Cell line : - Source : - Sample Type : PBMCs and Tumor tissue No. of Sample : - Stage : - | PBMCs were co-cultured in vitro with tumor tissue and analyzed for NRP1 expression. | Unknown | - | NRP1 is upregulated on TILs and can be induced on PBMCs by tumor tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| Chromosome | 10 |
| Location | 10p12 |
| Start | 33466419 |
| End | 33623833 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 157415 |
| OMIM ID | 602069 |
| HGNC ID | HGNC:8004 |
| Unigene ID | Hs.131704 |
| Ensembl ID | ENSG00000099250 |
| PharmGKB ID | PA31783 |
Protein Information
| Protein ID | NP_001019799.1 |
|---|---|
| Protein Name | neuropilin 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 923 |
| Uniprot ID | O95990 |
| Ensembl Protein ID | ENSP00000354270 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Glycosylation | 612 |
| S | Glycosylation | 612 |
| S | Phosphorylation | 894 |
| Y | Phosphorylation | 899 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3791 | KDR | 1867 | NP_002244.1 | in vitro;in vivo | 113 332 711 722 279 000 000 000 |
| 5228 | PGF | 3076 | NP_002623.2 | in vitro;in vivo | 11986311 |
| 6405 | SEMA3F | 3079 | NP_004177.3 | in vitro;in vivo | 9883722 |
| 7422 | VEGFA | 1889 | NP_001020537.2 | in vitro;in vivo | 119 863 111 040 967 000 000 000 000 000 000 000 000 |
| 7423 | VEGFB | 3237 | NP_003368.1 | in vivo | 10409677 |
| 7869 | SEMA3B | 3179 | NP_004627.1 | in vivo | 10196546 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
| HTLV-I infection | hsa05166 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06263 | 650-803 | MAM |
| cl18943 | 650-803 | MAM superfamily |
| cd00057 | 277-423 | FA58C |
| cl19067 | 277-423 | FA58C superfamily |
| cd00041 | 27-140 | CUB |
| cl00049 | 27-140 | CUB superfamily |
| cd00041 | 147-264 | CUB |
| cl00049 | 147-264 | CUB superfamily |
| cd00057 | 435-582 | FA58C |
| cl19067 | 435-582 | FA58C superfamily |
| pfam00431 | 147-262 | CUB |
| smart00231 | 274-424 | FA58C |
| pfam00431 | 27-138 | CUB |
| pfam11980 | 843-920 | DUF3481 |
| cl13423 | 843-920 | DUF3481 superfamily |
| smart00042 | 156-262 | CUB |
| smart00042 | 37-138 | CUB |
| pfam00754 | 290-421 | F5_F8_type_C |
| pfam00754 | 446-580 | F5_F8_type_C |
| smart00231 | 430-583 | FA58C |
| smart00137 | 645-804 | MAM |
| pfam00629 | 650-811 | MAM |
Ontology Information
| HPRD ID | 5470 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Cytoskeletal protein binding (GO:0008092) |
| Biological Process | Regulation of cell cycle (GO:0000074) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| O14786 | DB00039 | Palifermin | BiotechDrug |
| O14786 | DB04895 | Pegaptanib | BiotechDrug |