CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SOCS2	8835	suppressor of cytokine signaling 2	12	STATI2, SSI2, SOCS-2, SSI-2, CIS2, Cish2

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20348236	2010	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry, Plasma IGF-I Assay,real time RT-PCR,Immunoblotting, Western Blotting	Down-regulation	-	Reduced expression or epigenetic silencing of SOCS2 may serve as a useful biomarker for colorectal cancer risk.

Gene Details

Chromosome 12 - NC_000012.12 (93569822..93626236)
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Gene Type	protein coding
Gene Family	Suppressors of cytokine signaling, "SH2 domain containing"
Description	This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Chromosome	12
Location	12q
Start	93569822
End	93626236
Strand	+
Gene Sequence	>gi\|568815586:93569822-93626236 Homo sapiens chromosome 12, GRCh38.p2 Primary Assembly AGCCGCGGCCTCAACTAAAAGTGGCCATTGACCTTTCAAGCTTTCGAGCAGTGATGCAATAGAATAGTAT TTCAAAGAAAAATGCTTATCGAAATTTTGGATCCGGTTTTCCCGTGATTGTTAAGGGTTTCTTTTAAAAA GTAGGTCACATTTCAAGTAGGTCATATTTCGGGGGCGGGTGCGCAGACAAGGAGATGAGTTTCCACTAAG GCCAGGGGGCCTCCAACGGGGTTGGAGGTGAGAATCCCAGGTAGGGTAGAGGTGCCGAGATCCTTCCGAA TCCCAGCCCTGGGGCGTCAGCCCTGCAGGGAATGGCAGAGACACTCTCCGGACTGAGGGAACCGAGGCCA GTCACCAAGCCCCTTCCGGGCGCGCAGGTAAGGGCGCCCCCTTAGCAGCCGGCGCAGGTGACCCGGGCGG GCCGCCGGGTCTACCGGAGACGTTGGAGCAGAGGGGAGGAGGAAGGGAGGAGCCGGGTGGGTGCGGGTGA CAAGGAGCCGGAGCGCCAGGGGGAGGGGACTAAGGACGGCCGGCGCCGCTTAAGGAGGCGCTGCTCTCCC GCTCGCTGCCTTCCAGGACCTGATCAAGGGGACCGCCTCCGGTCCCCGGCCGTGGGCACCGGGACGAGCA CGGCGTCCCCACGCCATCGATGTGTCTTAGAGCCGGAGAGTCTGGTTTCCGAGGACCCACAGTCGCTCCT GCACGCCCACCCCCCGCAAAAGTGCGGCCAGGAGGGTCGCATCGAGGGGGCGCCGCCGGGATGTTTAGAG GAACCCACCCCCGTGGCAGGCCAAGGGCCAAGGATCGCTATCCTTCCCTGAACCCGGGCGCTCAGCTGGC CCGGGTAGGGGGCAGGCTCCGGCCGCCGAAACGGGGTTGGCTGTAGCCGGTGGCCGGGGAGATCTCTAGC TTGCGCCCGAGCACCCCGGGGTGTGGGGCCAGAGGCAGGCCGACCCCGGCGTGCACACCGCCCGCCCTGC ACCCGAGCGCTCTCACCCGGTCTTCCCTGAAGCCTGTGTATTGCGACCGAGCCTCTTTAAAGCAGTAGCG GGGCCCGCGGTCACGTGAGGCCGATTCCTGGAAAGTTCCTGGAAAGCCGCCTCCGCAGCAGCCGGGCGGG GCGCGAGCGGAGCGCTGACTGGGGAGGGAGGCGGGGAGCAAGGGAGGCGCGTCGGTCTGGGAAGTCGCGC GCACTCGCTGCTCCTGGGACCGACGTTTAACTCTTGCCAAGTCTCGTCGCAGCCGCCGCGGCTGGCGGGC CTTGGGCTTCCCCTGAAGCATGAGCCCTCTCGCCCGCAGCCACCCTCACCGCGTGGCCCGCGGACAGTGC GCGCCGGGGTCCCGGGTGCACAGCCTCAGGATACCCCGTGCCCGCAGCTCGGGCGCCCGCGGCAGGTACC GGTAGTGGGGGAAGCCCGAAGGCTCCGCCCCGAGGAGAGTTACCGGGGAGGGCGGCGAGGCGCGGCCGCG TGCGCCGGGGAGCGGCGGACGGCCTGGGCTTCCGCAGCTCGGAGCGCCGGGGAAGAGAGAGTCCGAACCG CGGCTCTGCCCCGCGGCCTAGCGTTGCTGCCTGCTTTCTCCAGCCCCTTCTCGGCGTCTGGAAGTGTCTG GAGTTTCTTTTTTTTATTTCCCCTAAACTGCCATTCAAATTAATAATCCTCCTAATAACCTGATCTCCCG CTCCTCCCCACCGGCCTGCCTCCCGCCCTCGCTCCTTCCTCCCTCCCTCCCTCTCTCCTTCCCACCTCCA GGGTCGCAGCCGGAGGGAAACCCGGCAGCAGTCCGAGAGTGGAGGTGTCCCAGCCCGTAGGGGGCGTCGC CGCGCGGTGGGGGATGGGGTCGAGGCAATGATCCTCGAGGCTTTTGTGTGCCCTCTGCGCACGGAACTCC GACCGCCGCCTCCGAGCGCGGGGCTGGTTGCATCCCCGGGCATCTCGTTCCCAAATTAAACGTTAACGGG GGAAACAAGGGCAGACGCCCCTCCTCTCCCGGGCCCCTCCCACCTCCCCTTTTCCCCCCACCCCCCCGCC CCATGTCCGCTGAGGAGGCTGCCTGGTGCGGAGGCGGCGGCGGCGGCCGCGGCCGAGGTCGAGGTAAGAG CGCGGCGTTGGTGGTTTGCATTTTCCGCAGCGCTCGCGACCGCCCGCTCGGCCCCGGCCTCGCCTCGGAG CCCCGCGAGGGCTGCGCGCTCGGGCCGATTCCTCGACAGCGCCCGCGGCGGCGAGAACCACCGCAGCCAT CCTGGTCCGGGAGCGACCGCCGCGGCACCCCCAACCCCGCCAGAGCGGGCACCAGGAAGCGGGGGGAGGG GAGCGAGGAGCCTCCCGGGCGGAGATGCGGCAGCTCCCGCACCTCCGCACCCCGGGTTGGTGCCTCGGGG CCCCGCAGCGCTTTAGGGCGGAGAACCAAGTTTGTGTGGGTGCTTCTTCCTGGGGGCCCTCGGGCTGCGC CAGGTGTGAGACCGGAATGCCAATTTGGGGAATCTCTCCTGTTCTTTCCTTTTTAATTTTTTCTACTTGT CCTTGACAAGGGCCTATTCCCACTGGATCTGCAGGTGACTATTTGCTCTTCCTAGGTCGCCAGTCTTTGA TTTCAGCTAGTGACCCTGGGCGGGAAGACACCCTGTTCACCCTCCTCCTGACCTCCGCCCCCCACCTCTT CAGCCAACTTTATCTTGGATCTCTGCTCTCTTTATCTTTTCTCTAGAGCTGGGCCAGGGCGCTAACTGGA AGCTTGGGGTTAAATGGTGCAGGAACGTAGAGGCGGAGGAGTCCCTGGGATTTTCCACGTCTATTTCCCC ACCCCCACCCCAGCCGCAGGGGTCCAGTTTGGACTGACCCAACCTCCCGCTTTCTCTTTGTAGGCGATCA GTGGGTGACCGCGGCTGCGAGGGACTTTGTCATCCGTCCTCCAGGATCTGGGGAGAAAGAGCCCCATCCC TTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTCGTTTTGGGATTCGCACTGACTTCAAGGAAG GACGCGAACCCTTCTCTGACCCCAGCTCGGGCGGCCACCTGTCTTTGCCGCGGTGACCCTTCTCTCATGA CCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGGGGAAGGGACGCGGAGCCAGTGGGGGACCGCGGGGTC GGCGGAGGAGCCATCCCCGCAGGCGGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGTAGG GAGCCGATCGGCCGCGACGCGTGCGGGAGGGAGCGCCTCCCCAAGGAAGCAGCTAGGAAGCGGGGTCGAG GTGGGAAGCAAAGAATAAGATGGAAATACGTCCCTTGCTTCCAAGGGACCGCGGAGAGCACGCTCGCAGG GTCCTGGGTCCTTGGGAATGCGTAAGGAAAGTGGTTCTCCAGGGACTCAGGCCTGGCGGAGCGCAGAGCG CGGGAAGAGCTTCTTGGAAATAGCTTCTTAGCACGCTGGAAGATTTACTGTTTTCCGCAGCTGCTCAGGG TTAGGCTCCCGGGCTCGAACCCCGGCCGGGGAAAGCGTCGGGCGCCTCCCTTTGCACGGGGTGCAATCAG CAAGTCGGTGCCGCGGGCCCCGCAGGCCCAGCAGCATCTGGCTCCCGGGCGGAGCTGCGGCTGCAGCCCA GGATCTTGGCGGCCAAGTTCAGGGACTGACACTGCCGCGAGGGCGGCTGCCCGGGCGTCGAGAGTAGGCT GCGAAGCCCCCGCCGAGCGCGGCTTCCATGGTCGGCGCGCCCAGGGTACTGCCGCTTTCAAGTACAGTCA GGCAATTCGCGCGGCACGCTGTCTCTAGGCATCTGAAAAAAGAAAAAAGAAAAAAAGTAAAGTATCTGGC AAATCATTCTGGCTTTCCAAATCCGTATCCTAAAAGCTTACAGTTGTGGCACAGTTGAAATTTTGGTAGC AACAGGGGGAGGGAGAGGGAAAAGTTCTCTCGCTTGCGATTCCGGTCTTTCCGTGTGGGCCACGGGCTTT CCCTCCCGGGGAGGCACCGGCAGATTGCAAGTATCCCGGTAATTGTGGGGGTGGGGGGAGCACAAATGTT CAGACTTCTTAAATACGGACGGTCTCTGAGCCTTCTTAGAAAGCAGAGTGGGCCGGGGAGATGGTGCAGG CAGATGAAATCAAGAATGCAGGGGAGATGGATGGTTGTGATTGGGTTTGGATTAGGGCAAAGTTCAAAAG AGTTTAGGGAAGATTGTAAACTTGAAGTAGTAATTATCACTTGGGAATTCCCATTTCTTAGTGACTGGTA AGGTAGTCATAAAGCAGCGAACAGAAGCTATTGTACTAGAGCTGTGCTTTTACAACAAGTACATAGCAGT GCTTTCTACATAGAAGGCTGTTCATAGCAGGCTTTGCAGATTCTTTTTTTTTTTTTTTTTTTTTTTTTGG TGGGGGGCACACCAACCATCCAAAAAAGTTGCTTCTGTTTTTACTGTAGTTCAATTACAGGAGTTGGGTT TTCCACTTTTTAAAGGGCATGGCTTTTATTTCTAACTTCTGATTTTTTTCTAATTTACCTAAATCTTTAT TTTACTTAAATAATGTTAAAAGTGTCATGCTTCATCAGCCAGTGTGTCATGCTGCAGATGTTCTTTTGGT TCATTAGAAGAAAATCTTAAGAAGAGCTTCAGAAAGTTGATTTTTTAAAAAAGAAAGAAAACTGGCTCGC CGTTTGTGTTCATAAAATGGACCCAAATTTTTATTAAATTCCTACTGAAAGTATTTGTGGTGGCCCGGTA AACTTTCGCTCACACACCACCTTTTTTTTTTTTCTTTTTTAGAGCTAAAAAAATTATTGCCAATTACTTG CTCTGTTCTAAGAATTCTTATAATAACTGTTTTACCCTCTTTTCTTTTTCTTTTTGAACAAAAACCCCAG GATGGTACTGGGGAAGTATGACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTT CTTGATTAGAGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGACCAACT AATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGTGTCAAATCCAAGCTTA AACAATTTGACAGTGTGGTTCATCTGATCGACTACTATGTTCAGATGTGCAAGGATAAGCGGACAGGTCC AGAAGCCCCCCGGAACGGCACTGTTCACCTTTATCTGACCAAACCGCTCTACACGTCAGCACCATCTCTG CAGCATCTCTGTAGGCTCACCATTAACAAATGTACCGGTGCCATCTGGGGACTGCCTTTACCAACAAGAC TAAAAGATTACTTGGAAGAATATAAATTCCAGGTATAAATGTTTCTCTTTTTTTAAACATGTCTCACATA GAGTATCTCCGAATGCAGCTATGTAAAAGAGAACCAAAACTTGAGTGCTCTGGATAACTATATGGAATGC TTTCTAAGAACAGCTGAAGCTAATCTAATTTAAATTTAACAGCTTGAAGAGGTAGCTAGGTGTTTAAAGT TCCTCCAGATACTTTTACCTGAGTGATGCTTCCCTTCCTAAGGCTGACCAAGACCTGTTGATCCTTTTAG ATTAAAAATAAAATGTCGCATGTAAAGGCTGAAGTCGCGTTTTATCAGAATGCCTTGCCTTCTTAGGTTC TTTTCCATTATGTCAAAGGTCCAGGCTCCAGTAGGAGAGAAAGAACTCCTCATAGGAATACTGAAGAAGT GGGAAGGAACCAAGCTGACACAGGCCTCACTGCAATTTGATATGCCTGCTGATCAGAGTCTCTTGGGCAT TTTATATTTTGCATTCTGATGTACCTAGGAGTTTTGTTAAACAGATGATGTATGTGAGTATTTATCCCAT TTTATGCAATTAACCAAATCAACCAAAAAAAGTGACCATGAAGTCCTGTATTTGTCTTTTTACTACATGT AGGAACTCTCATGTGAATGAGTACTGTAGTAATCCATTCTATGGGAGCCTTATTTCAGAAATATTTCAAA CTGGTGCAAATGGAAAAGACTTTCTCTTTTCCTTTAAAGCTAAAGACAAGAATATCATGCTATACAGGTG CAACTCAATCCCCGTTAATAAAAACCAATGTAGGTATAGGCATTCTACCCTTTGAAATAGCTGTGTCCCA ACCTGTTGCCATTGATTTTTTGGAAATGGCTTTAGAAATATCCAAGTTGTCCTTGAATTGTCTAACCATG GACATAAACAGTTGTCTCCCTTCTACTGTGTAGAATACTTTGACTTAATTTTCTTCCAGATACAGGGGGA TACCTGCCTGTTTTTCAAAGTGTTTATTTACTGCTGTTACTATTTGATTAGAATGTATTAAATAAAAAAA ACCTGATTTCTACAAGTTGCACTTATTGAGTTCTAGAGAACGTACACTTTCATGGTAATAGAGGATTGCC ATAAAAACTTACGTCAAGTGAAATAAGCCAATTATTCAACAAAAGGTAGAACATTACTTGCCATTCTGTA AAGTTATGGGCTGTACCTGCCCCCTTTGCAATTTGGAAAGCATGGTTTAGAAACTACAGGCATTGTCAAG TGGCCGGGTCTTTTATAATTTGAATAGGCATAACACTGATGTCCTCTGTGTTTCCAAAAACATGGTTTAG AAACTACAAACATTATGACATGGCCAGTCTTTTACAAGTTGAGTAGGCATAATACTAAAGAAAAATACAA AGTTTTGTGGCCACTTATTTTTTGCTATGTTAGTCTGCATAACTGTTATAAATGTACCATCTTTTCTAGA GTCCAGACATTATTTATTTTATGGCTTTAAAATTTTCCTGCATAGCTACAATCCTGTGGTGTGTCACCAT AAAGGTGGACCCTGTGTGAATGAGAAAATTCAGTTATAAATTGTAATAAAACCTGCTTACTGGATATCTT ACCTTATTTTCATGAAGAAGTTGAAAAATGGTTTTGTGCCTGGCAGGAAACATACTATGTATATCCAAAC AGCAGAGCCAAACACAAAAGATTGCTAGGTGTGCCTCAGGAAGAGTTTACTTGTGGCCTAAAACTTCAAG AAAAGCTAGACATTTGGGGTCGGATCTATGATGGGGCCATAACCATTTGATGAGGATGCTTAGAATCTGT GCTTCATTCACCGTTTTTCTCCCACTGACAACACCTGTTTAGTGTTGGATGTTTGATTTTTCTGGCAAAA CTTCTATATGATCAGTGCCAAGGGGCTTTGTGGAATTTCTTTAAAGGTCTTTTGCCTTTCTATTGTCACT GTTTTGAACACTCTATTTCTCAGTTACTGGGAGTGGGGAGGCAGTTGTGAGGCATGAGTACCTGTGAAAT TGGAAAAAGTTCTGAGTTACTGCTCGCAAGTGACTAATTATGAGAAGGCTGGAGGACAGCACAAACATCT CTGGAGTGTGCCATGAAACCTATTGCCTTATATTTCAATCTTCCATATTGCAAGTAGGTTGATAAACATC AGGAGGCAATTATTTTTGGTTTTGTTTTGTTTTTTTACGATGACTGACATCATTTATTTATTGAGTTTAT TGTGAACCAGGTTCTCACTCAGCACTTGTATTATCTCATTTAATTTTCCCAAGAACGAAATGAGCAAAGT ACAATGATGATAGGAGGTTCCCCTCCTGATTTGTGAGTCAAGAGGCATTCCAGGAATATCCTAGCTCTTT TTTTTTTTTTTTTCCCCCGGGAGAGGAATTGGGAAGAGCAAATTGCTGCTGAAAATTTCTACATTGATCC AGACAAACAAGTTAGAGCAGGCTGAAAAAGAACCCTTGGTGTTTTTACTGCTGTTCAACCAGATCAACTG GAAAAGTATAGATACCTTAATTAGCACTGTGCTCTGTGGGATTCTGGTCAGCCTGGCCCAGTGGTTTTTT TCCCCTGAACACGCCTGAAAGGGGAGCTCATAATGACTGCTGTGCAGGTGGGCGGGGAGGGGGCTTCCTA TTTGATTTAGTGGCTGATCAATGCCAGTTACCAATTATTGGTAGCCCCATTTATACATGGTGGAAAAAAA GTACACTTGTCTAAATTATCCTCACCAAAGCCTGGAAGAATATCCAGTGTTTTCTCCCAATGTAGGGCAA TTTAGGGCATTTGTGAGGATATTTATTATTGTTGTTGTTGAAGAATATGGTATACAAGACTTATATATCC CCAAACTCTGAAAATATTTTGACCTCAGTTTCTGTTCTGGGCAGAGATGAGGCAGTGCAGTTTTTCATGA CCATTACAGTGAGCAGTGGTGATTGCTTTTTAGGGACTTGGAGATTTTTTGGAACTTTGGATAGTGGAGA AAAAGGCAGTTCAGCTTATGAGATGAGAGGTCTTTTTTGGTGTGTCAGTAAGAAAGTCTTGACTTCATAA TAATTATGTAATCCAAATAGGTAACAGAATGGGACAGTTGTTTGGGAGTGTTTATTTTCTTGGGAAGGAT TTTCTCTGCTTTTAGAAAATTGTACCCTGTTAGGAGGGTAGGAGACAGAGACGTCATCTTCGTCAAGTAA TCCAAAGGATGGAATGTCCTGAGACCAGGCTATGCCCTTCTCAGTTGTGAGTTTAGGCACGGGGTAGGTG GGGTTTGAGTGGCTGTGGTTATGTCTAACAGCTGGGCTGAAGTCTCCGTCTTTAAGTCGTCCTTTCTATC CTTTAGAGCAAAACAATGTTCTTGTAGGCCTTTCATTTACTTAAGAGGTCTTCTGTATTCTCCTTTCCCA GTTTTTTTAACTTCTTAGAATTTTAAAGCTTGAAACCACTTTTTAGATCACATATTATGGATTTTATGGA AGACTTTCAGATCCAGAGGGGCTGGGAGATTTGCATGCTCGCACACACACACACACACACACACACACAC AGGCACACAACCCAGCCAATCAATGACAGAGTCAGGATTCAAACGCAGATATTTTAGTCTTAGGATTACT ATTTGTAAAAGTTGCACGCTCCTACCCTTTGATAAAATTGCCGAGACTCTTCTTTGCTTTCCTGCAAGTC CTACAGTTCTCTTAACATCATATATTTCTTCCGCTGGGATTCAGAAGCCAGGCCTGTGGAATACCCTGTG GGATAATTACAGTTCTTGGCCTCCTCTACCCGATTCTGAAAAATCTGCCTCTGCTGGATTTCATGATGTC TTGATCCACATTAGTTTTTTGTTGATTTTAACTCCTTAACATTTCTAATCTGTTTGCTGTTTTAAAATCC AAAACCTCCCATCCATGCTGTTTGATGATCTCATTTCTACCTCCACCAGATGTGACACACACCCAGCCAC AATGCCTGGGCGACTGCCCGCCCTCCCATCCTTACCAGCAGGACCCATTCTTGCTTTTGCCCATTCATGG GCATAAGGGATAGTTAATTCCTGCCTTACTTTCTCCCTTTCCTATCATAAAGTTGCCCTCTTGACTTATC TAACACAGCCTTTCTGGCCGCATGATACTCCAGTGAAAGAGGATAATTATACTCTCCTTGAGTTGGGTAA TTGAATGATTTGGACTACCTTAAGATTAAATCTCTTTGTATCTCTTTTTGGTTCCATTCAGGTTGTGAAG CAAGTAACCAGCCCCAGATGCCACACTTTTGTTATGGGCATTTTTTTTTTAAATCTACTTATTTTTTAAG TATGGCAGGCTCCTTTTTCAGTGTTAAGTTAACCTTCATTTGCACGGAATAAAAATGCCCTCCATTCCTT TGCTTCTGCTGCTGTATGTCTGTAAGTAAGAACGATTCTGTGAGAGTTTTGTTTCATTTCTTCATATGCA TGGTTCTTATATTCTCATCTTCACATATTTTTGATTTTTCTAACTTTTCCTCTGTGTGGCTTGAGTTCAG GTGACTATTACTATGGTAATAAAGGTAACAAGTGTTGTTAGAGTGGCCTCTAAAAGTCCTGGAGTCCCCA GTGTCTGAAGTCATGGAGCAGAGCTGGCTTTTCCTATCTACCCCTTCCTGAGCTTTGTCAGCAAAGGAGG CTGGATCAGCTAAGTGTGCCACAGAGAATAGGACTTACTTCAATAAACATGCATTTGTAAAGATAAAACT AACTGCTTTTACAGACAACTCTCACTTTGACCCACATCCTTAACTTATAGGCATTCTGACTTGCCCTAGA TCAGAAGTGCATTTTGTGATGTATTATTCACGTGGCTTTGCCTCTCTTAGAGAAAGGCTTGCCAGAGTCC TAGTGAGAGAAAAGGAAATATCGCCAGCTGCCTTCTTCTCCTGTCTCAGCATAAATGCCACCCAAGGAGC CCCCTTGCCATGGTGGGGTGAGACTTTTTCGCCAGTTAAACCATCACACAACTTCATAAAATTTTCCTAC ATCTCCCCAGTTTCCGGTTTCCTACAGTGTTAAAGATAAAAATTTGTTTGTTTTTGCTAAGCATTTTTTC CCTTCTGTTAGTTTGGTATCCTTTTTCCTGTTTAGTGTTTGGTCCAGAATGCTGCTGTGATCTTTAACAT TCAGAAAAAATCCATGTTAGCCAGGCACAGTGGCTCATGCCTGCAATCCCAGCACTTTGGGAGGCCAAGG TGGACGGATCACTTGAGGTCAGGAGTTCGAGCCAGCCTGGCCAACATGGCGAAACCACATCTCTACTAAA AATACAAAAATTAGCCAGGTGTGGTGGCGCACACCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAG AATTGCTTGAACCTGGGATGCAGAGGTTGCTGTGAGCGGCAATCTTACCACTGCACTCCAGCCTGGGCAA CAGAGTGAGACTGTCTCAAAAAAAAAAAAAAAAAAAAAAGAAAAGGAAAAGAAAAAGAGGCCATGTTATT TCTACCCAGAGAAAGTTGTTTGACTTCCCATTTTAACATTCCCCCTTGCCATCTTGATGAACTTGACCCA TCTTAGGTTTCCAGCATAGCTTGTTTCTCTTCATTTTTATTTCTAGGTTGTGGCCATCAATTCTGTATTT GGTCAGAAAGTGTCTTTGTATTTTGCATATTGGATTAGAGCATCTGCTCTTAATTATCTGTAGGAATAAG AGGCAGAGAGACTGGGGAATAGTAGAAGCCCATAAACACATCTAGCCAATAGTTTCAACTTCCTCCCCAT TCTGTCTCCTTTGCTAGAACCACTGACAGAAAAATCAGCTGCTTCTCTGTTCTCTCATTTTATTTTCCTT GTCCATCATGTGATAGGGATGTTAATATGCAACAAACTGGCTAAAAAAATATCAAGAGAGAAAAGTAAGG GAGATGGAGCATCAGTAGTGTGTGGAGGCTCCTGAGAGTCAATTACTAAAAACTGAGAGATTTTGTGAGC TCAATCATTATGCATAAATTATTGATAGATTGAATCAGCCATGGTGGGAGTATTACACCACAGAAATAGG CAGATGCTATAAATTAAGACTCTCCGCCACCAGATAGCTGATTTAACAACATAGCACTGATCTAGGTATT ATGTCCTCCTCAATAATTGAGACCTCATTAGGGTAAGATCAGTTTATTTGTAGCCTCTTTTATACCAAGC CCAGTGCTTAGAGCAGAATAGGAGTGAACAATTCAAGGAATGATTTTTTTTTTTTTTAATGTGTGTCAAT CTTATATTGGGTTACATTGTCTTCTACTATGGATCAGGCCATCTCCTGATTCTGTGTCTTTTTCTAGTTA CTCTGGGGTATCTGTAGCTACCTTTTCAATTTCTTAGTAGGAAGGTGTTAGGCAATCTCAACATCATGTG ATCATTGTTTACAACAACTCAGCTCTAATAGATCAGGGCCTCTTTTTTCCTTCTAGCTTCGTTCATTTAT CTCATTAGTTTTCTCTTTTTTTTTCTTCCTCCCTCCCTTCTCACCTGCTTTCTCCCTCCTTCTCTCCTTT CTGCCAACGTTTATTGAATGTCTACTGTATTACTCAACAGTAGGAAGTGTTCTTTCATTGAGGGAGCTCT TACAGACCATGAGAAAGGATGGAGAGGATGGGGACTAACATTTATTAAACAGTCTAATATATCCCATTAC CCTGCTTAGCCATTGCATTTCATCTTCACAACAACCTGATGAGGTATGTATGACCCTCATTTATTCCAAA TGAAACAGAAACTTAGGTCAAATATCCTGCCCAGTCAAGTAGGGAAGTCATGAATCAAACCCAGGTTCTG CATCTCAGGATACCATATTGTATAGGAGCTGTAATTACATGAATAACTTATTGTAAAATGCATTGTTAAA GGCAGTGTAGTTACTTTGCGGACAGGGTGCCATTGACCTGCTTTGAGGGTTTATGAAGACAAGCCCCCAG AGGAAGGTATCTTGTGTCTGAGTGTTAATAGACTGGAAGGAGTCCTCAGACCTGCTGAGTGGGGAAGATC TTTTGGCTGAAAGGTTGAAGAAGAGGGTAGAGATGAGGCTTCTGGGAGGTGCTGTCTGAGGGTGACTTGG GGCAGATCTTGCAGGCCTGGCTGAAAACCTTGGAATTTATCCTGAGGGCAGTAGGGAGCAGATGTCAGCT TTTTAAATGGAGGGGAAAACAACAGAACTAAGTTTGTGTTTTATATCATCCCTCTGGAGGTCCTTTGGAA AAATGGCTTGGAACAAAGCAAGGGCGGAGAGAGGGAGACCGGTTAAGTGTTAGGTAGGAGGGAGGTAGTC CTTGTGAGAAGATTGGAGAGAGAGTCAGAGGTTGACTCTTTCCTTCCTTGGCTGCAGGCTCAGATTTGCC CTGGAGTATGCGGCTTTGAGTCACACAGATTGCACGCTTCCCTTTGAGGAGCGGCTTCCACTTTGGGCAA GTTGGGGTAACTGGCACAGATTCTCTTCTCAGGAAAGCAAGAGGTCGCGGTGCAGCGGGCACAACCCTGA ACTAGGAATTGGAAAACTTGGGGTCCACTCTGGTTCTCTGACCTTGGGCCAAACATTGAATCTCTGTTAT CTGTAAATTGAAGAGCCTGGAGCCTTCAGGATTTTTGGTCCCTTCCAAGGAGGTCCCATCTGCCCAGATG TGATAGTACATTGGGGTGAGAGTGCTCAGAGGAGAGGCAGGCTCCACCTATCAGTGGAGTCTCAGTTTCT ACGTAGATTGTAGTACAGATTTTACCTCTATGCTATAATATATTCTCATTTATTTTGAAAATATACTTCC TTCTTAACTCTGGGTTTTGTTTTTTTTTTTTTTTTTCACAGCCAGCTGTTTTTTATCCTGGTTAGAAGAA TTTTGTGTTTTCTTTTAGCTATGGATCTTTGAACATTACCCTATGATCGAAGAGTTTTGAGTTGGGTTTT TAGATGTTGGTTGTCATGGAGAAACAGGAATCTGGTGTATGCCAGCCATCATCATCATCATCATAACCCT TTGGATGAATTTTCATTATCAAGGGATCTGGAAGGCTGTCTTCGCTCTGCTTCCCAGCTAACAAACAGAT GTGTTCCCAGAAGATGATGGGCATAGGGTGTGTTTTTGCAAGTCATTTTTCCCATTTACGTAGATTATTC TTATTTCCAATTGATCCTCAATAGATAAGAGTGCCATTGAGCTTTATTTTCATCTGTCAGGCAATTAAGA AAAAAGTAAAGGAAACAAAAAAGCTATAATATACTAAGGAAATTCTTAGATTCTTTGGTAAAATTAAAAG AATCTTGGTGCATGAATGATCCGGCCCTAATCTATCCATCTTGCACATTTGGGTTTTCCTGGATCTCTCT TAAAGTGGGGCACATCTCTGGTCTTGATAGTCAAGGAGGAGGGTTGGGGTAATCAGATGTCTCAAGCAGA GGTGCATCATTGAGCCTGGGTAATGGCTGAAAGTCCCCCAGATATCCAGTTTGAAGCTGCGTTGGGCAGG CCATGGGTTTTATTACGTCCAAGGCGTGACAGGCAACCATTCTATAACAGACCAACTCTTGGGCTTCCAG AAGACTGAAAAAAGCTAGAACATTTACTAATGCCAGGTGTTGCATTTGACACTTTACAAGTATAACCTCA CTGAAAGTTCCCCACAAACATCTGAAGTAGATTCTGCTTTTATCTCCACTTCAGAGACAAGGAGATTGAC ACTTACACAGATTAAATGATTTAATAGTGTCGAAAGACAAAATCACAACAATTTCTCTTAAAGATCTTAA TTACCTTTATTTGCAATTCCAGAATTGGGTAACACTTCATTCCATAAAATAGAGTAAGTGTTCCAATTAG CTAAGCAGAAGAGGTTGGTTTTACAGCCAGAGAGGAGTAGAAGAAAGCAAAAAACAGAACCCAGAGTGGA TTGGTCCTTTCAAAGTTAAGTTCCTTGTAAGGTGGGGACAGGGAGACAGAACAATAGAAAAGTAACTGAT TGGTTAACATCAGGTTACTCCAGGTTACTTTTTTGTAAGGATTACAGTAGAGGGAACTTAATTATCATGC TGATTGAAACTAGCCTGCTTGGGAAATTAGGCTGTTACCTCTCTCCCGATTTCTCAGAGGGTCAGATAAC AACCTATTTTCAGTTTGGTAAAAATCTCAGCTTGAGTGACTCCATTTTGATTAAATTAGATTTTTGGGGT CTAGTGCAAGACCTTAGTCCAAAACAATGACTTTCTATAATTTTTATTTAACAGGAGGGAAACTTGAGAT TTGAATTCAAGCCACTCTGACTCAAAAGCCATGGTTTTCTCACTCTTTTGTTCATTTTCTCAATAAGCTT GCAAATGCTTTTAACCTCTGATGCCTGCAGCCAGCATGTACCTCAATATTGTCTGCTAGTCACATGTAGG TAATATTTCATCATGTGGTTAATACTAAGAGGGCTATGACCTCTTAATAATGATGCATCTTAATAATGAT GCTATTATTGGGACTTTGATTTCAGAAGTAATGCAAGATCTGCCTAAATCCTAATTATCCAGCTTGGAAG AGTCCCTGACATCTGAATTTACACCTTTTCTTCCCTTCTTTTTTTTTTGAGACGGAGTTTCGCTTTTGTT GCCTAGGCTGGAGTGCAATGGCATGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCT CTCGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACCATGCCCAACTAATTTTTGTATTTT TTGTAGAGACAGCGTTTCACCATGTTGGCCAGGCTAGTCTCAAACTCCTGACCTCAGGTGATTCACCTGT CTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCATCACGCCTGGCCATTCCTCCCTTCTTTTAAT CTCCTTTAGGTGTCTATCCAGTGCAACCATAACCCACAAGCTCTTCCCTATCACTCCTTTCCTTTCTCTG GAGGTAAATTTTATAAATGATGTGTCCATCATAATAGCCATTTTACGTTGCAGAACAAACAACCCCAAAC TCTCGGTGGCTTAAAACAATAAAGATTTCTACATCTATACACATCTGTCATAATCACCAGGGAGGCTCTT TTAGCCACTCAGAACCAGGCTGATGAAGCAGCTGCAGCACCTCCTCAAACAGCTGGTCTGAGGTGCTGAG CTGATGGGCAAGGAGAATCAGAGGATCTCTTAGTGGTGTTTAAATGCCCTGTCACTTCTGCTCCTGACAG ATTGGCCAGAACTCTGTAAAATAGTGCCACCCAACCATAAGGGGGCCAGGAAGCACAGTTCTCCCCTGTG CCAAGAAGGAGAGAAACAGAAATGTTTGGTGAGCGGCATGGTGTAACCACCACATATACCATGCCATATA TATCCTGCTTCCTTCTTTTTTTCTGCCTAGCTTGGCAAATCTGACTTCACGTAAACTTTATAGAACATGT ATAGCCTCTTTAATTCCATTTCTCTTTCGCCTTTGTCTTCCAAAAGTTTTTCAGGTACTGCAAAACAGTG TCTCTCCTTCGTGTAAGCCAAAAGGAAAGATCTCAAGCCTTGAAGTGAAATATACATAATTCATCCCTCA GTATCTTCAGGGATTGATCCCAGGACTCCCGCCCCTGCCCCCTCAAAAGCCCTGCCAAGGATACCAAAAT CTGAAGATGCTTAAATCTCTTATATGAAACGGTATAGTATTTGCATATAACCGGCATACACCCTCACATA TACCTTAAATCATCTCTAAATTACTTAATAATACCTGATACATGTAAATACTATGTAAATAGTTGTTATA CTATATTTTAAAGGTTTGTATTATTTATTAGTATTGTATTGTTATTTTTTATTGCTTTTTTTTCCCTCCC CCAAATATTTTCGTTCTGTGGTTGGTTGGATCCGTGGATGGGAAACCCACGGGTACAGAGGACTGACCAT ATTAAAGAGTTAGGGCTACTAACCTCAAAAAGTTTCTGAATGACCGGAAGTTCTTCTGATCTTCACAAAC ATCTCTTGGGTTTTCTCACTTGCTAAAATTAAATCTGTCTTTTCTCCAGTGTCAATATTCAAGATAAATA AATTATGTTCACATTCACTCCTATTGTTTACTGTTTTGCTTAATTGGCTATATTTCAATAATATTAAATG GTATTATTTTCTACCAGTTTTTAATCAGACTTGAAGCTTTTCAGGCACATTAGAGAGTAAATGGACTTTT GTGTGATAAATTGGGTACCTAATCACCAATTTTAATTTACTTCTGAGGAAAATTCTATTGTAAATTCCAG ACAACTGGTTTGCAAACCCTGCTTTAGAATGCAACCTCTTTCTAGGATGAGGCCTTTTTCTGTAGCAAAT TTCTGTATAACGAAAATACCAGAATAAATGCTGGGTTTTAATGGACAGTTATGCTCTACTACATTCATGA AAAATGTACTTAATTTACAACTCTACTGAACACAATTCAGTTTTTTCCTTCGTTCAGTTTTTTTTCATTT CAGTTTTTCTACTCTAACCCAGATTGAAACTTTGCATTATCTTTAACTTCTCTGTCTTTATATTTATTTC CTTCATTTAGTTATTCATTTTTTCAATCATTCATTCACTCACTCATTCAATAAATATTTACTGAGCATCT ACTTGTTGTAGTCATGAAGCAAGGTTCTGAGGAATGTTAAAAAACACAGTCCCTGGCCGGGCACAGTGGC TCACACCTGTAATCCCAGCACTTTGGGAGGCCGACACGGGTGGATCACTTGAGGCCAGGAGTTCAAGACC AGCCTGGCCAACATGGCAAAACCCTGTTTCTACTAAAATTACAAAAATTCGCCAGGTGTGATGGCGTGTG CCTGTAGTCTCAGCTACTCTGGAGGCTGAGGCACGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGT GTGCTGAGATGGCACCACTGCACTCCTGCCTGGGTGACAGAGTGAGACTGTCTTAAAGAAAAAACAAAAA CAAAAAACATAGTCCCCGACCTCAAGGAGATTCTGTATAGCAGAGAAACACACAAGCCAGCATGCCATGA TACATGGTACAATAAGATAATGGCTGCAACGGAGGTCTCTGCAAAGAGCAGCTGAGCAGAGAAGACCTAT CTGGATCTGTTTGAAGGAGTCAAGAAAGAAATCAGAAAGGAGGCAGCTTTTCATCTGAGACTTAAAAAAT CAGTTGGTGGCTGGGCGCAGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCAGAGGTGGGCAGATC ACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAA GTAGCCGGGCGTGGTGGCACGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGA ACCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTGCAGCCTGGGTGACAGAGCGAGA CTCTGTCTAAAAAAAAAAAAAAAAAAAAGTTTGGCTAGGCCAAAGAGCCAGGCAAGGCAGTTCCAAGTAG AGCAGACCACACGAAGGTGTGAGAGAACACAGTTTGTTCCCATAAGTTCTACCACTGTGGGTGGAGCTTC AAATGCAAAAGAGGAAACCAACTAGGAGATAACCCTAAGTTGGTGGGCAGGGAACTGAGCACTCAGGGCT TTGCCTGCCTCTCAAAAGAGTTTGTATTTTATGTGGGAAGTGAAGGAGCTATCGAAGGCTTTTGAACAAC AGAGTGACCGCATCAGATTTGGTGGCAATATGGAGGCTGCTCTGGAGGGACGTGACCTGAGATCAGGGCT TCTGAACTTTATCCCTAGACTTGCAAGGGACCCATGGATAAGATGTCTGGGATCTGTGAACTTGGATTGG AAAAAAGCGTTATACTGTCATTTTCACTATCCTCTAAACTGAAATTTAGCATTTCCTTCAAATAAGAATC TAGGCAACGGATCACAGTAGAATTAACAGAAGATGTGAGTTTATCACCAGTAGAAATGCTCTGATAGCAT ATTACAGTTGTTGTAGGTATTTCAAAATATCTTTTACACTTATCACTAAACTGAAATTATTATAGATATT AGACTCACTGCCATAAATTGTTACTTAATGAATTAATAAAGAACATATATAACTGTGTGACAAATATAAA AAATAATTTGATATTTACATTTTAATATAATGTATCTTTTGTTTTTATTTTATGATTTAAGCACAGTATT CTGAGAAGGGGTCCATAAAAAAAGTCAAAACTCAACACACCAGAGGATGTGAGTCAAAACTCACATCACC AAAGGAACGTGATCGTTGAGGAGGTCAGTGTAGCCTAAGGCAGCGATGGGGAGAAGGAGGAAGAGGAGTT GGAAGAATTTGTGAGAAATTCTGGAGACAGTGAATTTTTTTTTTTTTTTTTGAGCCAGAGTCTCGCTCTG TTGCCCAGAGACTAGACTGCAATGGCATGTTCTTGGCTCACTGCAATCTCCACCTCCCAGGTTCAAGCAA TTCTCCTGTCTCAGCCTTCCAAGTATCTGGGACTACAGGCATGCACCACCAAGCCTAGCTAATTTTTTTT TTTTATTTTTAGTGGAGAAGGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGA TCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCTGACAGAGTG AATTTGTTGATAGATCAGGGACATAAAGCAGGGGTAGGGGTACGCATAGACCCCATTTCCTCCAGCAGTT TTCTGGCTGGAGCAGAATGCTTATGCTTGCCACATGTGTTCCTTTCTTCCCAGTGCTATCATTATTTACC GTACAGCATGGTTTAAAACACGGAAAACATCCATCCTTTGCTTCCCTCCTCTGTGCCTGCCAGTCCTACA CCTTTCTCAACTCTTTTAGTGTTATCTTCTCCAGCTAGACTGCAGATTCTGGGCAGGCAGTGCCTTGCAG TCTGCGACCCCATCATATATTTTTCACAGTTGATGTTGAATACATGACTGATAGATTTCAAAGGCATTTC CTGTTTTGAGGTCACCATGTACACCATATTCTAGTTACAGAAATTATACCAACCTTGACATTCTGGGAAT TTTTTTTTTAAATTCCCATGGGTTCTATCATTTGTCTTCTCATAAAATAATACAAAATGTGCAAATAAAA AAATCCATATGCTTGGGCTTCCTGATTGTTTTTATTAAAGTGAGTTTAGTGATGGTGGGTTAAATAATGC TGTAATCTTAAGCCAGAAATTGAGAATATGGATTTGAAATGTCCCCATTCCCTTTTTTTGTTTGTTTTTG TTTTGTTTTGTTTGCTGTTGCATGTTCTTGGCAGCAGTGGTTGATGTCAGTATTGTTGCCCATGTTGTAG ACTGCAGATGTTGCAGTGTAGCTTAGTACTTTGGTTCGCTTGCTGAAATTCCTCACTGTGCTTCTTATGA GGTCCAGGAACATATAGATTTGCAGTCTGATGTATTTTGATGATTGCCAGATAAAACTGATGTCTGGCAC TTTTTCCAGGAGAAACACATGTAGACGTTTCCAAGTTGATTTGTAGGGACTTAGTGTTATTAGAACTTTG TGGCAAAACTTTTTCTCAAGTGGCAGAAGAAATAAAGGAACTTCAGTTTTGAGGGCTGTTAACAGCACTT CCATTAGTGGCAAAGCTGAGATGGTTGACAAAGTACTGGATTGTTGAGATGGACCTTCCAGGCCGGGTGT GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGAGCGGATCATGAGGTCAGGAGTTCGA GACCAGCCTGACCAACACGATGAAACTCCATCTCTACCAAAAATACAAAAATTGGCCTGGTGTGGTGGTG CGCGCCTATAATCTCAGCTACTCAGGAGGCTTGAACCCGGTAGGTGGAGGTTGTAGTAAGCTGAGATCGC GCCACTGCACTCCAGACTGGGTGACAGAGCGAGACTCAGTCTCAAAAAAAAAAAAGAATAAGCAAGTACT GTATTTGGACTTTTAAGCATTACTGATACAGTAAAATACAGTTTTAGCTACCGACGCAAGACTAGCACCC AAGATTTTAGAAAAAGGCACTTTTTCCCTTTTATTTTCCAATAACATTTCTCAATCTGGTAACCAGAGAG ACTACTCTGGGATTAATTTGAGTCTGATTGCTGTTTACTGTTCTAACAAGAACAGTTTTTTTGGAGAGGA GAGCAGAGTTTAGGAGAAACGAACTATTAAAAGTTAGCTTCCCGTATGGGCGTGGTGGCTCAGGCCTGTA ATCCCAGCACTTTGGGAGGCCGAAGTGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCCAACA TGGTGAAACCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCACGTGCCTGTAATCCCAGC TACTCCGGAGGCTGAGGCAGAAAGAATCGCTTGAACCCAGCAGGCAGAGCCGAGATGGCGCCACTGCACT CCAGCCTGGGCGACAGAGCAAGACTCCGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AGTTAGCTTCCCAGTGTACACATGAAAAGTACAATCCTTTTCTTCATTTATATTATAATTATTTGAAGAG CAAATTAGGTATTGTTAGTGAAGAAATGAGAGTGATTACCTGGTAATATGATGAGTTACTTTTTCTTTAA ACTTACTGGCTTTTCCCTTAACACTAATGGTCTGGATAACAAGTTTTTACTTGTTGGCAGTGCAGTTTAG CCTCCGAACACTCTTGGAACAAAATGACTAATTTTTTTTAACGCTTTATTGAAATATAAATTTTAGGAGA GTAAACATTTTCGATTTGGAAGAAGTAGTTACGTTACAGACCTTCAAATCCAGCTTGTTCGGGAGACTTG ACATTTAATCACTAGGCTAATGAAGCGCCAGAAGAGAGAGCTTTTATGGTTAGAAAGGGAGGTGTTTTTT AAAAAAAAAACAAACGAACAAACAAAAAAAAAAAAACAAGGCTCAGCCCGAGATACTGGAAGCGACTTGA CCTTGATTTACATATACAAGGAACGGAAATGAATTAGCCCGGCTAGATATTTCTAGGAACTAGTTAAGGG AGAATGAACAAGATGGGAGCGAGGAGAAAGCGTGTGTGCGTTCGTGTGTGGCTGTCTGTCTGTCTGTCTG CGGCAAGAGGAATCTCAGAGTTTCGGTTATTTCTCCTTGAAGAATTTTCAAACGGAGTTCCTGCAGGGGC TGGCTCTAGCGTCTACGATGTGCACACACTGTCTCTCAAGAGGGAAGTGATCCTGGCGCCACGGGGTGAT GCAGCAGAAGTTCTTTTTGTCTGTGGCCAGGGTAGAGTGCGGAGCCCCACGGAGCTGTGGCGTGGCGGCT CCTCCCAGACGCGTCCGGGGCGCCGCTCGGGTCTCCCAGGACCTTATGTAACCCAGCGTCGGCAGCAAGG AGCCGGTCACAGGCTGACCAACGTCAAGGCGTTTCACTTTGGAAGCGCACCAGATGAGTGTGGTATTGAG AGCAGACGGCTGGGTGCAATGTTTTTGCCGCATATCTCATGGGTTATTTTAATCTTTTCACGTAGTCTTA AGGGTCTCACTAGACCGTATATGAGAATGTGGCCAGGGATGTGGCTTCTATAGATTGTCCCAGATAAGAG CATCCCTTTTGTTTTTGTTAATGCAGGGTAAATACAACCTCTTCTTAGGAGCTAGTTTTTCAATTATTCT AAAAGTGATAACATGCTCATGGTTCAAAATTTAGTCAGTTCAGAAGTGCACAAAATGAAAAAATTGTCCA ACTCCCGTCCCACTCCCCAGAGGTAACTATTATTAAAAGTTTCCTTTTTATTGTTCCAGAATTTTTTTAA TGCAGTCGAAGCCTCTATTTAAATCATGTTTTAAAGCACACACAAATATTATTGTACTATACTTTCTGCT CTGCAATTTGCTTTTAAAATTTAATATTTGGACTCTCTATGTCTACCTTTCTCTCTATATATCTATTTAT ATCTTCATGGCAACATAAGGCTTTGCCTCATTCTTTTCAACAGCTGCACAATATTCCATGATATGAATGT ACCATTACTGATTGAATCAGTCTCCTGCTAGTGGATATACAGGTTGTTCCCAGTTTCGTGCTATTACAAA CAACGGTGCGGTACAAATCTGTGTGCTAATTGTTGCTGTGTGCTTATGGGAACATATATGTTGAGTACAT TCTTAGAAGTGGAACTTTGGGGCCCAAGGGTACATGGCACTTAACATTTTAATAGATATTTACTTTCAAA TCACATTCCCAAAAGGTTGTTCCCATGCATATTTCAGATGGAAATAAATTCTGTCTTTCAAGTTGTACAC ATAGCTGAGGGTTTTCCTTAAAATACTGTTCATTTTTAAACAGCATATTTTCCATTGAGATCGAATAAAC TTGTTTATTTGCTAATTAATTGCCCTTGAAGTTAAATCTCTATTCTAGAAAAGATGTCTGAGAAACCTAG TGGAAAGGCCTCAACAACTTCGTCCCAGCCTTGATCAGAGACATTCACAGCTATGGGACAGGCACATGGC TCTATGCCTTGACTGTGGCTTCATAGACAGCTGTCTTTAAAAACCCTAGGGTAGGACTGAGAAAGCTTTT TTTTTTTTTTTTTTTTTGGTATGTGTAATAATATCATCTTCAATTAGTTCTGTTCAAAGGACATCGATTA AGCACAACTATAGTAAAAGTTTCTCCAGTTCCCTACTCTCTGTCCCCTTATCCTGGTTTCCTGCCTTCTC TCTCCCCTTTTGTGTTTGTTTCTTTTCATACCAGTTATCCTCTGCACCCACTCCTGACACCAGATTGGGT GGCCAGTTCTAGGAACAATGAAACTGATTTCCTACAACTGGAAGGTGGTTCTGGAGAGGGAATTAGCTTT GCCTAAGATTATTATCACGCTGACCCGACTCTATATCTAGATCCTGCCTCCAGTGGGATAGCTGATCTGC TATGACTCCCAAATGCCTAAAGCTCTCCGCCTACTCAGAAACACAGCATCTTCTTTAAAGCTCCAGAAGA GAGAGCTTTTATGGTTAGAGAAGGAGGTTTAAGAAAAGCAAACAAATAGGGCTCAGCCTGAGATACTGGA AGCAACTTGACCTTGATTTACATATACAAGGAACAGAAATAAATTAGATATTAGAATTAAATTAAAATCA AATTTTAATTTAGATTTGTATAGGTAAGACCTATTACAGATGAAGCCAGATACCAAGATATGTTTCAAAA AACATGTGGTTCACATTGCTATTAAATTGTTTATAAATGATCATAGTAGCATCCCAATTACCTTTTAGAT TATAGCCAACTTTTTGGGAATTACAGGACTTTTACAAGTATTTTATTTCCCAAATTACCTGCTTATCTGG AAAATAACCCTAGTAAGACCAAGCCCACTCATCCTGAAAACTCATCTTAAATGAAGCCAAGTCAAGTCAG AATAAGATCTGGGTGTCAGCAAAAAGGAAAACAAACAAACAAAAATCAAACCGAACCACGCTAAAATAAA ATAAAATAAATTTCCCATTTAAAGTCTGAATCCCTTTGGCTTTGTAAGCTACTGTTACCATACAGAGGCA TCTGCCTTAAAATAAAGGAAATAAATCAAGAGCGTAGAAAACCTGTTTAATCAAAACTCTTAATTTCAAA TCAGTGTTTCCATAACACATTACAAGCCAGCAGGAAGAGAGGGGAGGCAAAATGTGCAGTTCCATGATGT CCCCAAATAGAATGTTCACAACTGACAGGAAGCACCTGGGGGATTATGATTATTTGCTTTAGAAATTCAA AAATAAATTGTTTTTTGAAATAAAAAGGGAAGAACAAATCGGTTTCTCAGTTCAGGTTGTTTTTAACACT TCACACACATCCATTTTTATAATCCCAATTCAGAAGACAATGAATTCAAGTTAATAATGTATTTAAATTT AAGGATAATGCAGAGAATGTCAAAATAGAAAATTGCAATAGAACAGTTGAGCTGAACTCTGAGGCTCCTT TTCTTATTTTGACTCAAGTTGACCTTCAATATTATAGTACTTTCATTTTTACAGCTCTTTACATATTCTG TAAAAAAGCTTTTAAAAAGTGAAATGAAGATGTTTCTTAACTATTAAATTTCTATTGCCTAACTCTTTTA ATTTTTTGAGTCCATTAAGACTTTAGAAGATATTCTTTCTCAAATGTGTCATTTAATTAACAATTTGCTA ATGGCCTTGATAGGATTTTTCCATTTTTGTTTTCCAAATCAAGAAATCTCCATGTTCCTTTTATTATTTT CACTTTGTTTCTTTAGATATAATTCTTGTTTTTCCTGGATAATTAGTATAGAATTTATTTATTGTAGAGA ACTCTGTTCTGACAGCTGATAATATAAATATATGTTTGACCCACATTACTAGAAAGAATGTTATGTAAGG GAGTTTGTCAGGGAATATCAGCTCTCGAACACTGGGAGTTCAGGGAAAGAAATGAATTTGTAGGTCATTG ATCTTTGTGTTTTAAATAAGAATTAACCAAGAATTTTATGGTTACATAACCAGTACATGAACTAGTTTTT ACTACATTTTGTTAATACATCGAATTGAATAATCCAATTCAAAACATAGGGTACCAATTCCTCTTGTCAG CAATACTTTGAAAGTAGGGATTTATTGAGAGTTCTTTTATTGCCTTGACTTCCTTACGTTTGTAAACTAT GTGATGGGTATTACACTTAGATTTATTAGGGTACTTAAAATCTTGCCAAAATGAAACAATCTCTTTTTGT CATAAGTATTGCCGACTTAAAAGCATTTGTGAGGGGACGGGGGGTGATTTTGCTTTTGGAGTCTTACTCG TTACTGAAAATAAAATATGCTCAGCTTTTTCTTTTTCTAGTAGACATTTATTTTACTGAGTTCCACACTG ATAGTTAACTTTAGGAAATGCTTCACATATTTTAACTAATTTTATGATTTAATTTTTAAAAAGGAGGTAC ATTTTAGAATTTTTTCCCCCTTTTAGATACCTGACTTACGTGTTTCTGAAGATAAATTGCAGATCCAGTC ACTATAAATTCAGTTGAAAGACCAATCTTTCTACCCTTCTTTGTTGTTCTGATTTCAGAATTCCAGGCCA GTTTGTTGTCAACTTTAATGTACCTTTTGAGAAATAAATTGAGTCTCACATTTCTTGCATGTGTTTGTGC CCCTAGAGCTGGAATGCTTTTCTTCGGCCAACTGAAAGTAGAGCCTGCTCCTTCTCCTCTCACAGATTAA ATCTGCTTTCATTCGTGTTAAATTCAGTTAGTTCATGACCAAAAGAAAAGACGTGCTCTCCTTTTTCTTT TTAATTTTAAACAACCACCATCTATAGTCTTCCTGTAGTTTTTGAGAGCTTCAAGTTATATAGCTATTTT TGACTTTGTGTTTGGTTAATCTAATAGAGTCTACATTTTTGGGAGGCATTTAATTTGTGATTATCCCTTA TTGTAGTCTACAGAGTCACATCAACAAAATGAGCTGTTTTATTTTATTTTACTTTACTTTCTTTTCTGGT CTTTTTGTTTTGTAATTTATTTTTAAATTTATTAATTTGTTTTTAATTTTTTTTTATGTGATTCTTCCAG CTACTTTCCAGTAGCAAATAGAGGGCAAAAACAGTCATAATTTTATTGAATTTGCCTCACCCCTGTGTTT GCCCCTGTTCCTACTTACTCACAATTTAATACTTCTCAGAACTTTCACATTTCACCTAGCATGGAAACCT GATTGTTAAATGGTTGGATAGGACAGTGTGTAGGAGAATCCTTGGGATCAATAATAGACATATTTGGGTT TATTTCACAGGTATTAGGCTGTGTTTCTTGACTTTTAGTTGAGTGCTTACTCTTGCCAAATTTTATGCCA TGCACTTTACATACATTATTTGATTTAATCCCCATAACACCATGCTTGGCATGAAACCACATAGTCTGTT TACATTTTGCAGATGAAGAAACTGAGGCTCAAAGAAGGTTAAAGTAGAAAGGCATCCCTTTACTAAGTGG CAGAGCCGAGATTTGAATCAGCTTATCTGATTTTAATACCTGATTTAATATTTAATATTTGGGATCTTAA GCTATGCCATGCAGCCTGAGTTACTAACTGGGAAGTCATGGTTATATCAGATTCCTAAGATAAGACTACC AAGAGACCCAGGCCCATGCATTTGATCTCTTGAATGTTCAAAGGAAACTGCAGGGGCTGGGCACAGTGAC TCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACATGAAGCCAGGAGTTTGAGACC AGCCTGGCTAATATGGCAAAACTCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGTTGGCCTGCG CCTGTAATCTCAGCTACTTGAGAGGCTGAGGCATGAGAATTGCTTGAACCTGGGAGCTGGAGGTTGCAGT GAGCCAAGATTACACCACTGCACTCTAGACTGGGAGACGGAGCAAGACCCTGTCTCAAACAAACAACAAC AACAACAAAGCTGCAGGTTCTGCAGGCCTTTCTGCCCTGCACCCTCCACCACCTACTACAAATTGTCTTT CTTCTTGGGGGCCTCACTTGTCTCATCTGTAAAATAGAAGTATTATTTCATGTGGTCTATATCTCTCCTT TAAAAGAACACATTTTTAAAAATTTCAAAAGAATTATAGATCTCAAAGGAAGTTGTGGAGATAGTACAGA GAAGGCCTGTGTACCTGTCACCCAGTTTCCCCCCAGTGGTTGGCTACATCTTTTGTAACTATAGCACAAG TAAACCAGAAAACTGATCTTGGTATAAAGTGTTTGTGTAGTTCTGTGCCATTTTATTACCTGTAGATTGG CGTAACCACCACTGAAATCAGGATACAGAACTATCATTACAAAGATCTCCTTTGTGCTACCCATTTATAG TGACTCCCACATTCCTAACCCTTTGCAGCTGCTGATTTGTTACCTATCACTATAATTTTATCATTTCAAA TCCCTTTTTTTTTTGAGACACAGTCTTGCTCTGTTGCCCAGGCATGATCTCAGCTCACTGCAAAACCTCC TTCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTTGGACTACAGTTGTGCGCCACCA CACCCGCCTAATTTCTGTATTTTCAGTAGAGATGGGGCTTTGCCATGTTGGCCAGGCTGGTCTCAAACTC GTGACCTCAAGCGATCCACCCACCTCAGACTCCCAAAGTGCTGAGATTACAGGTGTGAGCCGCCATGCCC GAACTCAAATCTCGCTTTTAAAAAATAATTTTTTGTATTATGAAATAGCTCATCAGAAAAGTACAGGGAA TATTGTAACAATACTTATGTAATCACCACTCAGCCATAACAGATAGCCAGATTTAATAAATATTGTTGTA CTTCCTTTGCTGATTTATTTTAAGGCATCTTTGTCCTACTTTTTGACCCTACTGACCTCCTACCCTCCCT AGAGATAAACTCTACCCAAAAGTTATTGTATATCCTTCCTGTCCATGTTTTTTCTGTTTCACTGCATAAC TAGGTGTCTACAAACACTATGTAGTTTAGCTTTGTAGGTTTTAAAAATTCACATAAGTCAACAAATATAT ATTGAGTGCCTACTGTGTGCTAGACCTCAGGAATATGGTAGTGAACAAGGCAAATCTTTTGTTCTAAATA TGTAAACATTTGAATACATGAGATAATTGCAGGCATCTGTAACTGTGTGAAAATGATAATATAGGATATC AGACTGGCAGGGAAAGTGGGGAAGTGAGGGGATTGGCAGGGCACCGAGGAAACACGTTGCTGACGATACT GTGTTTTCGATCAAAACCTGATTGATGAGAAGGAAGAGCAAGTGTTGATGCCTTAACGTAAGGATGAGTT TGGTTTGTACAAGGAAGGGCAACAAGCACAATGTGGCTGGAACAGTGTAGACTCCAGGGAGGAAGTAGGA GATGAGCTCAGAGGGGTAGAAGGTGAAGGTGGGAGGAGAGGGGGAGATTAGGAAGGACCAAAGAGATGGC ACCGAGGAGTTTGGGTTTTATTAAGGCTGCAGTGGGAAGCCATTGAAAGGTATAAGCAGGGTCATGCCAT AGTTATGATATAGGGGATGGCATAAAAGGCATTCAAGTGAGAAGAGTTAGGACGCTGTTTCCATTTTCCA GGGAAGAACTCAACCAGAGGGATGGTGATACCTTCTATTAAGATAGAAAGACTTGATATTGATTTATCTG TCTGGATTTGCCTGAAGGATTCAACATTGTTTCAAAATTTACTTATGTTGATACTTTTAGATAAAGTTAA CTCATTTTCATTGCTATGTATATTCCAATCTATGAGTACAGTATAACAAATTTTCTTTATCTATTAATTT ACTTATTAGTAGATGTTAAAGAAATTCTAGCTTTTTTACTCCTGTACACAATTCTGCCAAAGCATCCTTA CATAGAGAGGTTTGTGGATAGGATACTAGAGTTTCTCTGGAGTGTATATCTAGCAATAGAATTGCTGGGG TCTTTTTGATATGCTCATTGTCAACTTTGTCAGATAGTTCAAAATTGCTCTCCAAAGAGGTTGTACCAAT TATTGTCCCTAGTGCCTAGCTGTTTATGAGAATTTCCATTTCCTCACCTCCTCAACAGTTAGTGTTAAGC TTTTAACCATTGCTGATCTGATGGATTTAAAATCATATGTCATTGTTATAATTTGCATTTCCTGCTTACT AGTCACTATTTTTTTTGACCATTTAGATTTAGATTTCTTTTCTAATTCCTATTCCTGTCCTATGTCCAGT TTGCTGTTGTGCTGTTTGTCTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTTTGTGGTCCAGGGTG AAGTGCTTACGGTAACTTCAAACTCAGGCTCAAGCAATCCTCCTGCCCCAGCCTCCCAAGTGGCTGGAAC TACAGGCATGCACCACCACTCCTGGCTAGTTTTTAATTTTAATTTTTATTTGTATAGATGGGGTCTTGCA ATGTTGCCCAGGCTGGTCTTGAATTCCTGGCCTCAAGTGATCCTCCCACTTTGGCCTCCCAAAGCGCTAG GATTACAGGCATGAGCCACTGTGCCCAGGCTGTTTATTCTTTTTGAGTTATAGGATTTCTTTACATATTC CAGGTAAACAATCCTTCGTTGGATTTTAAGCATTGATATATACATTGAAAAAACCTTTGTTGGCTTTTAT GCACTACTGTGGTTTGAATGTATCCCCCAGAGTTAATCCCCAGTGCAACAGTGTTGAGGAGAGGTGGGAC CTTTAATAGATGATTAGGTCATGAGGGCTCTGCCTTCTTAAATGGATTAATGTAGTTATAATGAGAGCGA GTTTATTATTTCAAGAGTGGGTTTGTTATAAAAGCAAGTTTGGCTTTCTCTTGCTCTCTTGCACATGCAT GCTGTCTTGCTCTTTTGCCTTCTACTGTAAGATGATGTAGCAAGAAGGCCCTTGCCAGATGCTGGCACCT AGATATTAGATTTCCCAGCCCATAGAAGTGTGAGAAATAAAATTCTTCATATGTTACCCTGCCTCAGGTA TTGTGTTATAGCAACACAAAATGGACTAAGACATGCACTGAAATAATTTTGTCTTCCAGTTTTAGCTTGT CTTTTCACTGTTTAAAGTAATGCTTTACATTTACAATATTACTGTAGTCAGATTTACCAATCTTATTCTT TACATTTTGTGTTTTCCTACCCTGTCATAAATATATTCAAGTTGTGCTTTTCACTTTAGTTGTTGAATTC ACCTGAAAAAAAAATTAATAAATGGAGATAAAGGTATAGATTTAAAAAAAATTATTTTTCTTTTCTTTAT GGAAAATGAACTAACCCAGTACCACTTATTGAACAGTCTTTTCCTTTCCCTACTGATTTTTAATGTTACC TTTGTAATATATCAAGTTTTCCATAAGCATGGGTCTGTTTATGAGCTCACTATTCTGTTCTGCTCTTCTA TTTGTCCGTCTCCACACCAGTGCCATTCTTTTGTAATTACTATAGCTTTATAATAACTTTGCTATCTAGT GTGGTGAGTGGTTTTTGTTTATTCTTCTGTGTTATCTTGGCCATTTTTGATTCTTTACTCTTTGATACTA GCTTAAGGATCAACTTGTCAAATGCTGTGATGGGAAAATGTATAGATTTTAATTGTAATTACAATGAATT TATAGATTAATCTGAAAACAATTGCCATCTTTGAGCTTTTCCATCCCATACATGAACATGAATATCCTTT CATTTATAGAGATTTTTTTATGTACCTCAATCAAGCTTCACTTCATAATGATCTTGTATTTCCTTTGTTA AATCTGTTTATAAGTTACGTAAAGTTTTTTTTTTTTACTATTGTTAATGGAATCTTTTAAAATTTTGATT AAATAAAACATTTTATTATTTATTATTTTCATTTTTTTTTTTTTAGAGATGAGGTCTTGATCTGTCACCC GGGCTGGAGTGCAGTGACGTGATCATGGCTCACTGACGACTTAACCTCCTGGGCTCAAGGGGTCCTTTTG CTTCAGCCTCCCAAGTAGCTGGGACTACGATTGTGCATCACCACACCTGACTAATTTTTTTAAATTTTTT GTAGAGACAGGGTTTTGCTAAATTGCCCAAGCTGGCCTTGAACTCTTGCGCTCAAGTTATTCTCCTGCCT CGACCCCTGAAAGTGTTGGGATTATGGGTGTGAGCCACCTTGCCTGGCTGGAATCTCTCTCTCTCTCTTT TTTTTTTTTTTAAATATACCTTCTGTTAGTTTTGTGCTGGTATATGGGATCACTATTGATTTTTGGATAT TCATTTGTATCCAGCGACCTTTCTGAATTCTTACTAATTCTAATAGTTTGTCTGAAGAGTCTGGAGTTTT TAAAAATTTCATATTTATTTATTTATTATTATTACTTTTTTGAGACTGAGTCTTGGTCTGTCACCCAAGC TGGAGTGCAGCGGTGTGGTCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGGGATTTTCCATCCTT AGCCTCCCAAGTAGCTGGGATTACAGGCGCCCACCACCATGGCCGGCTTTTCAGTAGAGACTGGGTTTCA TCATGTTGGCCAGGCTGTTGTATTTTTTGTAGAGACTGGATTTCACCATGTTGGCCAGGTTGGTCTCGAA CTCCTGAACTCAAGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGAGAGCCACAGCG CCTGGCCAAAGTCTGGATTTTTTAAATGTATTTGTTCATATTGCTTATAAGTAGCTATTAGTTTTCTCAA AGAACGAGCATTTAGATAATCTCTTTAAGTCTCTCTTCCAAACTCTGTGATATATGATTCTATTCAGTGC TTTTGTATCTATATATGGGTAAAAATTAAGCATGACCACTCATTCTTGGTACATTGCACAATATCTTGAT GCATTATACAACTGTCTTTTTTTTATTCCTGCTTCCTATTCCTGTCTCTATTGAATTTACTAGAAAATTT TCACATAAACTTAGATTAAGATTTTAAAAATATATAGCAAAAGTAAAAATCTTTAAGAGATTTAACAACC TTATATCACTTGCTGATGACCATCAGCATGTACAGTTACTGACAGTGTGTGACTATAGACTCAAACACAT TCTAGACATATTACAGATTGCAAGATGGGGCCAAGAAAAAACAAGAAAAAGAGAATTATGTCAGTCCTTA GTATTTGTTTGTTTTTTTAAATACAAGGGCTTGCTGGGTCGGCCAGGCTGGAGTGCAGTGGCGCGATCAC AGCTGCCTGAAGCCTCCATCTCCAGGGCTCAAGCAATCCTTCTGCCTCAGCTTATCCTAGACTACAGGTG TGTGCCACTCCACCTGGCTAACTTTTTTAAAAATTTTTATTTTTAGTAGAGACGAGGTCTCACTATGTTG CTCAGGCTGTTCTCGAACTCCTGAGGTCAAACAATCCTCCTGCCTTGGCCTTTCAAGGTACTGGGATTAC AGGCATAAGCCACTGTCACTGGCCAATCCTCAGTATTTGTAGCATATACATACACATGAAAACCACACAT ATGAATGTATGTGTATGTATAAAGTCATGTGACCTGTACAACATATCGGCATGAGAATGTGTGAACGTGC TTCCTGTTCACATGTACTCCAGGAAATGGAACCAGTTTCCAATTAAGATTCAAAGGTATATGACAGGTCT ACAAGAGACTTTGGGAGATATTATTTCAGAGTTGAGTCCACTTCACCAGGCCTTTCAGACCAGGAGTGGC TCAAATTTGGGTAGTACTCACCACTTAGGATTATGGTCAGGGCAGTTCACAGGGTGCTTCGTAACAAAAC TCCCCTTCACTTCTCAGCTCCCAGGAAAGAAGGGGGCTCTTTCCTGCCTCAGAGCCCTGCATTCTGTAAT CCACTAAGATACTCACCTTGACTCTGCGAGGAGAGGGTGGTGACAGGGAAAACACAGAAGTCAGTGAACT CATACAACTCACAGCCAGGTTGTCATCTGGGTCCTTTCCATCTTTGTAGTTTTCTAGGTGAAGTAGCTGA CAAAGGGCCTGGCCTAGAGAGCGCTGCTGGGCCTGCTTTACTGGGTTGTCCAAACTTCCCTGGAGTGAGG TCCATTCAAGATGTGGGCTCAACTAAGAGGAAGTTACCAGACTATTTAGTCCACTGCCGAACCTTGGTCC GAGACCAAGTCGTAGCTGTTCCCCGAAGCTATGAGAGTAAACACTGCCTCCTATTTTTAGTAGTTAATTG CTTGCAAAAAATAGCTGGAAATCCAGACCTTTAAGTCTCAGCAGCCTTTAGCTTCACAGACCGTCCTGTG GCAACAACAATCTTAACAACAACAGTAAAAAAACCACTAACACTTACCTGGGGTCACTGTGTGCAGGGCC TTGTGCTATATGCATTGTTTTGTTTAATCCTCAGACTGAGTGGTCATTGTTATTATCCCTATTTTTTTAG GTGGGAAAAAGAAGACTCAAAAAGGTTAGGCCCTCTGCCTCAAGTCACACAGCCCTTCAGAAGCAGAACC AAGCCCAGTCCAAGTTAGTACAGCCTAAGGCTACAGCCTACGGTTTTGACCACTTCTCTTTCCCACCTTT CCACATCCCATAATGGCATCCATGGTGGGATGTTTATTACATGGATCTGGTCCAGTTTCCTCAAAGCACT TTCGTTGATAAACTGGACTCAATCAAGTTAAATAAACAAGAGATTATTACCTTTATTATTTTTTTTAAAG CCATTAGATTTACAAGTTACCTTGTCTTCCTCCTCATGTTCCCTTTTTTACAGAGAAACCCGGTATTTTT CCAGTGCAGTATTATTTGGGGTAATGCTTGACAATTTAAAGGGCACGCAGCAGTTGTGTGGAATGTAGTC TGAAAATGGCCAATAAAACCATCAGAGTATGAGCAAGCTCCAGGGTGGAACCAGAAATGTGGCCGCCTGC TCCTTGGGCTGATTGCTTTAGCAGAAAAATCAAGTTCAGGATCCTGTGTTTACTGAGATGATTGGCATGT ATTATCAGAGTAGCTGCACCTGGAAGATTTCCGACTTAAATCTATTGACTTCATGTAAATGGCATATGGA AAACAACAAATGATAGTTTGGTTGCCAAATAAAAGTACACAGAACACCCACATGGAGGCAACATGCTTGT TTCTATTTTGACAGCTCTCAGAGGGAAAACGTTGCGGTGTTGGCCTCTTCCTGGTGAGTCCTCATTGGGT ATATGGGTATAAAAAAGCTTTGAAACATCCTTTGCTCCTACTCTTCTGCACTCATAGATTCTCAAAAAAA CAAACAAAACAAAACAAAAAAAACAAGAAAAATAGTTTTTCTCACTGTTAATCCTCTGATGTGGAAAGAA TGTGAAAAGCAGACGACATTCTTACATGAATAAGCCATATATAAATGAAATATTGGGCAATGCCTATTTA AAAAAATTAACACCCAATAATCTGCATTTTTATTCCCCAGACCAAGCAGAAATGATTCATTTTATCCTAA TCTAATATTTTTATGCTTGAGTTTTATTGTTCAAATTAACAACAAAAACTACAATAAAAATGTAGTTTTG TCAGAAGAATGATTTTATAGGCACAGTTATGCCTGCCAAATATACCTAAACTCAATGTTTTAAGAAAAAA AACTGTGGTGGGTATTTTAGAAAGTTAGACTTACATTCGTAAAGTGTTTGGTCACCTATTAACATATGAG CAAGTTCAGAATTTTTGCATGTTGGGTTTTTTCTTTTTCTTTGCTTTTATTTATTTATGTTTTTTTGAGA CAGGGTTTCGTTTTGTCGCCCAAGCTGGAGTGTAGTGGTGCGATCACAGCTCACTGTAGCTTTGACCTCC CGGGCTCTAGTGATCCTCCCTCCTCAGCCCCCATCGTAGCTGGGATACAGGTGCACGGCCCCACACCTGG CTGATATTTTTTTCTTTTTTGTAGAGACAGGGTCCCACTATGTTGCCCAGGCTGGTGTCAAACTCCTGGT TTCAAGCGATCCTCCTGCCTTGGCCCCCGCAAAGTGCTAGGATTACAGGTGTCAGCCACTGTGCCGGCCT GGATTTTTTTTTTTTTTAAGTTGATTGCTCACATGTATAGGGTAAAATTTTTAGGAAATAAGCAGCCATG CCCACTCCCCACTCCTGCCCCAGTAGTCTTGTAATGTTATATGTCAAAGCAGCTCTCAGTGCTTTTACAT TTTCTTACTTTTAATTTAAAATTGTGTTTATAATGTATTTCAAATATACAAAAAGCACAGAGCACAGTAA TTACCAATGCCACCACCACCACCCACATTTAACAAGGATAGTTGTTGCGGCTTGTCTTTATCGCTCTCTT AAACGAGCAAGTTGCCGAGTGTTACACACACTATATAACTAACGTATATAAGATAAGAAATTACCCCAAA GTCTACTATGTATTGCTTATGGATACTTATACTTCTTAAGACATAAATACACAATGGGGAAAATACTTAA CCACTCCTGAAGGGCCATTACCTGTCAGAAATTGGGTGGATGAGGCCAGGGGCTTCAACCATACCTGTGA AGCCTTATTTTTAAAAAAAGTCATCTGAGGTGAATATGGGAAATGTTAATAGTTGTTGATCCCTGGAGAT TTTCAGTGTAAAGCATATGGTGAGACAGTTTGACTCTTCAAGCAGAAACTGGTCCCTTAGAAATGCACCT CCTCCGCCAATCAGGCACATTTGTAATTAACAAAAAGGAATTATGTGAAATGACTACAAGTGGATGCCTC CTGCATGCATTTCTATGGTATGAATATCACTTGAGTCAGGTAATGGGGAAAAAACAAATGTAAAAGAAAG GGAGCAGGGAAAGGAAATGTACTTCAAATTGTGTCCTTCCTAATTTTATTCTGTCTGACACTCTTCTGAG GGGCAGTAGAGGCAGAATTCATAACCTCCACCATCATCTTCATAATTGATATTTACTGAGTTCTTTATAA TGTGTCTGTCATTGCCAAGTACTTTACTTCAGATATTAGACAGGGTATAGTTTCATATGCCTGAACAGAG ACCCAAAGTAACAGCAGCTTAAACAAGATAGAATTTTATTTCTCACTCACATGACAGTCTGGACATATGT AGTCCATGACTGATATGATGGTTCCACGTGGGTCAAGGATCCAAGCTCCTCCTATCTTGTTGCTCTGCTC TTCCTAGAGTATCGCCCTTTTACTCATGACCCAAAATGGCTCTTGACTCTCCACTACAACATCTAGTTGT TGTTTATATTTCACTGGCCAGAATTTAATCATGTGAGTGCATCTGGCTGCAAGGAAAGCTGGGAAATTTG GTCTTTGTTCTGCACAGCTATGGATGGCAGCCATAAAAATTGGGGTTCTATTCCTGTAGAAGGAGAAGAG ATGGATATTGAGGGCCACTAGAAGTGCCACAAGTGGATAGTTTCTATTAATCCTTCTGACACTAGGAGTC AAGCCCAAGTTACCCCATTCAACACATCAGAAAAAGACTAGGTCAAATGCTGTAGGTCACACAGTTAATA CTTTGTGGAACTGCTGAGGTGTGGCTTTATTTTTGTTCCTTTTTGCTTTTGCATCTAGTTTGCTGAGAAG CTCTAATACTAGGATCAGGGCTGAGAGTTCTTGGCCTCCTTGGGATTACCATACCTCATCAGTGTTTGCT TGATTTCATCACACCTTTTAAAACAATTATCCAGCAAGGCACTTTGTGGTGTGTTCTTTAGAGTTGAAAA CAAGCACACATTTAATTGTTTTTGTTTTTGGGACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTGCAATG GTGCAATCTTGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATCCTCCTGCCTCAGCCTCCTGAGC AGCTGGGACTATAGGTGCCCACCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAAATGGGGCTTTGC CATGTTGGTCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCCACATGCCTTGGCCTCCCAAAATGCTG ACCTTACAGGCGTGAGCTACCACAACCGACCCATTTAATTTTGTTCAAGGAATTCTGTGACACTTATTTA GCAGTGGGTAGTACATTTGGGTGTTGCCTAATCAGAACTGGGGACCTAGACCAGGGAAATATCATTCTAT AGTTTGATTCAGATTATACCTGGCTTCTGGTTAGGCTAGAATATGTGCTCCCAAAATCTTTTAAATAAGG ACATCCTTTAATAAAATATGTGTTCTTTTTCTATAACATCTTTTTCTGAGCCCTATCTTGAGACCATAGA CTATCTCCTACATATTAATAAAAGATGGCAGATTTTCTAGGAATGGTTTTATTTGAAGGAGAAAAAAGTA GCATTGAAACCAGCTTTTGCTTTTCTACATCCTCCAACCACTGGCATCTTCCATGAAACACAATTTGATA AGGGAGTGATCCCTTTTTTCCACTCAGAGTACAATTTCCAAGAGATGGCATGTGCTGAAAACAAAACTTA AAAAGGGAACCTGGTTCCTGAGAGTTCACATTTGACATTTTTCAAGGTCATGCCAGATAAAAAGGATACA CCCCAGGAAGAAGAACACAAGATACCTGCTGTAGCCCTCTGCCTTTGGAAACGTTAAAATTGAAGTCATT GCATGGTGCAATACTGGAGTAAGGAATAGGGTGAGGCAAATGAGGCATTCACTCCTGACAGCAAAATTCA CAGGGGTGCCAAGCAAAATTCACAGGGATGCCAAACCCTTTGTAATCAAAATCAATACTATTTTAATGCA ATAGTTGAAACTTCATGACGAGCAAATATCAATATTTTAAATAAAAATACGCTGTCATTTGTTTGTTTTA CCATTCTGCATCATCGTGTGATGGGAACAGTCATTTCCAGTCAGCCTGAGGGTCCTGGCCCCCTGGAATA CCCCTCACTGTGTGGATTTATGAGGATTGACAATTGTGAGAACAGACTGTATGATGTGGGGCTTTATTAC AGTTACGGCTTCTAAAAAATTTATTCTCAACTTTATGGAAGAAAATTAGTCTGTCAACTAAATTTTGTTT TTAGTAGTTATGGATTTTGACTGTAAATCTTTTTTTTTTTTTTTTTTTGAGACAGGGCATCATTTATCAC CCAGGCTGGAATGCAGTGGTGCAATCATAACTCGCTGCAGCCTTGATCTCCTGAGCTCAAGTGATCCTCC TGCCTCAAACTCCTCAAACTCCATGTGCCAACATGCCTGGCCCTTTTTTTGTTTTTTGGTTTTTTTTTTG GTAATGACAGGGTCTTGTTACATTGGCCAGGCTGGTCTCGAACTCCTGTCCTCAAGTGATTCTCCCACCT TGGCCTCCCAAACTGTTGAGATTACAGGCATGAACCACCATACTTGGCAATGTTAAGCTTTTATTAATTT TTCTCACTTGGCTAAAAATACAGAAGGATATTTTGATGAATGTATATAGGAGGGCACATTTTTCTTTTGC TCCTGGCTCTAATGTGGCTCTACAGAGCACTGTTCTGGACCTCTGAGAAGCCTGTTCTTCATGCTAGATG AGTCATGGCTCATCTAGGTTCTATTTTCAGGATGACATCACTTACTAACTCTGTGACCTTGGGGCCTCAG TTTCCTCATCTGTAAAACTGAGGATGATATTACATAGTTCATATACATATACTTCATATACATGCAGCAC TATAGAACATGATGTAAGCACTATATAGACATGACATAAGCAATGTTGAACTATGTAAGTATTAGCAATT TTTGGTATTATTTCTGACAATGCGATGTCTTATTTATTGCTATGCCTTCTACCTTCTAAAAATCACCTCC TATATCACATTAAATCATCTCCCATTCCCTGATGGGATGCATCCCACTCGGTGCAACATCAGTTTAATGG AACCACCACAGGCTCTGGAAAGTTATATCCCTGAACCCCAAAATACTCAGCTTAATTGGTGTTCCTTTAA GCAGGTCACTAAGTTCTCTAAATTTGAATTTTCTAGATGAGGATAAAAATACCTACTTTCCAGGGGTAAG TATTTACCTTAATAAACACTGTAAGAGGCCAAGCATGCTGGCTCATGCCTGTAATTCCAGCACTTTGGGA GGCTGAGGCGGGCAGATAACTTGAGTTCAGGAGTTCAAGACCAGCCTGGGCAACATGGTGACACCCTGTC TCTATTTAAAAATAAATAGGCCAGGTACGGTGGCTCATGCCTGTAATCCCAGCACTTCGGGAGGCCGAGG CAGGCAAATCACCTGAGTTCAGGAGTTCGGGACCTGCCTGACCAACATGGCAAAACCCTGTCTCTACTAA AAATTCAAACATTATTTGGACGTGGTGGTGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTAAGGCAGGA GAATTGCTTGAACCCGGGAGACAGAGGTTGGGGTGAGCCAAGACTGTGCCATCACACTCCAGCCTGGGCA ACAAGAGTGAAACTCCATCTCAAAAATAAATAAGTAAATAAATAAATAAAGACTGTAAAATTTACTTATT TAGATAAAGTATTTTATTAATTTATTAATTTTTATTACCTTAATAATAAATTAATTACATTGATTTACTT AAATATTACCTTAATAATAATTATTTATCTTAATTTATTACCTTATTATTTACTTTAATTTATTACCTTT ATTATTTGGTAATAATAATTTGTAACTATGGGAATAAATAAGATCAGAGATAAAATAGAGAGCATCTATT CAAACACTTGAGCTGTAAAGGATGATCAGTAAATATTGGTTTACTTAAAAGCAGTAATTTATGACTGTTC CCTAGGGATCTGTGGAAATCTCCAGTGGAATCTTCAAACATGTTGCCTACTGTCTTAGTTTGTTTTGTGT TGCTACAACAGAATACCACAAACTAGGGTCATTTATAAAGAAAAGAAATTTATTTCTCACAGTTTAGGAG GCTGGAAAGTCCAATGTCAAGGTGCTGATATCTGGAGAGGGCCTTCTTGCAGTATCATCCCATGGTGGAA GGTGGAAGGGCAAGAGAGAACAAGAAAGCAAGAAGGGGCTGAAGTTGCTTTTAGAAGAAGCCTATTGACA TGGTAATGACATTAATTCATTCAAGAGAGCAGAGCCCTCATGATCTAATCACCTTTTAAAGGTCCCATCT CCCAACACAGTCGCACTGAGGATTAAGTTTTTAACATATGAACTTCAGGGAATACGTTCAAACTATAGCA CCCACCATATTATATTAATTGTAAAATATCCACACATATGTTACAACAGTCGTTCTCAGACTTTAGCACA CATAAGAATCATGTGGAGCTAGGGCAACCAAGTCATCTCAGATTGCCCTGGACTTTCCAGTTTTAGCACT AAAAGCCCCTCATCCCAGGACACCCCTCAGTCCCGGGCTAACCTGGATGGTTGGTCACTCTGCCTGGAGG ATTTGTTCAAACACAACTTCCTGGACCCCCACCTTTAGAGATTCTGATTCATCAGGTCTGATCTGAAGGG GAGCCTGTGAGTTTGTATTTCTGACAAAGCTCCCAAGTGCTGCAGGGGTGTCTGAGACCACAGTTTGAGT AACATTGTGCTATGACTTGAATCCATGTGTTCCTCCAAAGTCCATATGTTGAAACCTAATACCCAATGTG GTAATATTAAGAAGTAGGGCCTTTTGGAAAGTGATTGAGTCATGGGCACTCCAGTTCATGAATGGGCTCA GTACTCTCGTAGAAGAGGTAGAAGGGAGTGCCCTAGTCCGTTTTTGCCCTGCCATCTCTTTTGCCATGTG AAGACACAGTGTTCATCCGTTTTCTGCCCTTCCACCATGTAAGAACATGGCCATAAGGTGCCATCTTTGT AGCAGAGAATGGACCCTCATCAGACACTGAATCTCCTAGATCCTTAATCTTGGACTTCTCAGCCTCTGAA ACTATGAGCAATGAATTTCTGTTGTTTCTAAGTCACCCAGTCTAAGGTGTTTTTTTAATAGCAATAGGAA TGGACTAAGACACACTTTCACAATATCATACTAATGGCCATACTTGGTGTTTTATTTCTAAAAGTTGAGA ATTGCTCAATTTTTAGAACTCCACAGGGTTCCTTACATCCCTAGGAGGCTGGTGTTTTAACTCTCATTTT ATAAATCTTCAAGGAGGTGTCCTAGTCCCCCTAGTTTCCTGGCCTAGACTGGCCAGGAGATGAACTTCTG GCCAGTTATTACCATAGATCTGCAGTGGACACATAGAGACTCAAGTGGGGACCTCTGCTGAGCAAATTTT GCTTACATATCCCTTTTCTAATTAGGAACTGTCAAAAAATGATTTTTTTTTCTTTTTGAGACAGGAGACG GAGTCTCACTTTGCCACCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCACCTCCTT GGTTCAAGCGATTCTCCTGCCTTAGCCTCCTGAGTAGCTGGGATTGCAGGTGTGTGCCACCACGCCCGGC TAATTTTTGTATTTTTGTAGAGACGGGGTTTCACCATGTTGGCTAGGCTGGTTTCTAACTCCTGACCTCA AGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGAATTATGTGCATGAGCCACCTCGTCTGGCCAAGAA GCAATGTTTGCTTTGCAGACGGCATTATTTCAACAAATTTCACACCATCAGCTATAGCAACCAAAGCACC TAATTGCTTACCAAAAATGTATTTAAAAAATTCTCTTTCATTACACTGTAATTATTGGCAGCCCCAGGAG TCATATTTTATTCTGATTTTATGTTTCAGCACAATTTATCCAATTTCTGCAGTCCCCAAAATGCAGAATT GCTAAATGATTGCAGAAATAAACAAAATCTAATATTTTATTGTATTGTTTCAATAATCAGTACTATTATG TGTACATTTGGTAAGACTTCCTTTGATATTCAGTTTATATTGATTTTTTTTTTCATCTATCACAAAGGAG GCCTCCGTTGGTTTGCTTCTCTGTTTTCTTTACAACTCCTCCCTCTGCTCAGAGAACTGCTTTTTTTGTT TGATCAGCCCCCATCTACTGGTTATACTTTTGATTGAATTCTCAGTCAGGCCTTGTCATTTCTGGGATTG GAGCTTTTCCATGTAGCTCCAGGGAATGTTGTTCTTTGATTCCAGGAGATGCTAGAACGACCCTGTGAGC AACACCTACTTCATGGGGTTGGAAGCAAAATAAAAGGATGTATCTAAACTGCTAAACATGAGACCTGCCC ATTTTGCACTAAAAAAATTTCTCTGATCTGTCCATTTCCCTTCACACTTCCTCCCAACCCACTGCCTTTC CATGAATACTCCCCCTGCCTGAAATTCAACCTCTCCTGCAGTCTAGGTTGATTCCTCCATGGTACTTTTC CATGGTATCATGCACCTGTCCTTTGGAGCACCAATCACAGTGCCATTGTACTTTTTTTTTTTCTGTGATT ACTTCATGGCTGTCTTCCTCCTCTACACTGAGGACAACACTGAAAGGTCATTCCATATTTACAACTCCTT GTGAGGCTGGCCCAGGCTTCCTTTGAACCAGTTTCATATTTTGGCATTGTCCCCTGCTCAATCCTGCTAT CTTCACTTCTTTCCATGGTGTTAATCCTAAGTGTACTCCCTAAAGCAAACTATGCATTCTAATCTCTGTC TCAGAATCATCTTCCTAGGGAACCCAACTTGTGCCATGGTACTCCCAACATAGGGAGGAATTGTATTGTT TTTTTCCAATTGTGTATATTCTCAGTCTATCATAGTCCCTGGCACCAGGAGGATGTCAGCAGATAGCTGT GAAATGAATGAACAAATGAATCAATGAATCAATGGTGGTAGTATCATTGGTAATTTCTGTTTTATGCCCC ACCCTTCTCCTTTCTTTAAAGGCAATGTAACCCCTACACGGGAATTTCTTGGGTTTCTGCCCAGGGATCT ATTTTACTCCTCTTCATTTCCTTCCCTTTTCCCTTTTACAGCCCCTTTTTCTCCTACCCCTCCCTTTTGT AAAATCTCTGCCTAGCAATAGCTCTTAGCTGTAGCTAAGGAGTGAGGAGGAAGCCCAAGGAAAGTGGCTG AGAGACAAAGACGGAAAACAGCTAAATTAGTTTAGAGGCCAATTCAGGAACTCCGGCACTTCTTTCTATC AGAGCCTGTGTGGAGCCCTGCAAGAAAGGGCAATGCCAAGGAACAGAGGAAGCCAATATCTGAAGGCTCT GCTCATTGCATGGCTTTCCGAAGGTATTTTCTCCTTTTGAATGAGAATAAAGAGCCTTTTAAAACAACAA AGCTTCTGTATAAATAGAAAAAAGGGAGAACTCACATTTTCAGTCCATATGAAAAATAGCCTCTTCGTTA GTAATTTCTCATCCTCATGTACAGCCTACTGCGGTCAATGCTTTATTTCTGCAGCCCTGTTTTTTGTTTT TATGGTCCTTTTTTTCTTTTTCTTTTTGCTCCTTCCGCCCCTCCCAGAAAAAAAAACCAAAAACAAAAAC AAACAAACAAGCAAAAAAACAGATTCAAGCTAGAAGACTTGAGTTTGAGACCTAGTTCTACCACTTTAGT AGCTGCATACTGTCTCCGAGCCTTAGTTCTTTATCTGAAGGTGGGCATTTGTTAACCAGCTCACAGAGAC GGGCTACTGAGAAGCTCAAATGAAACAACGGATGTGAACAAGCTTTAAGAATTGTGACACTCTAAAGAGA AATTGTCATTGCCACTTAATTTTTAGTGAAACGGAACAGCATGCTGAATATAGTTAACAATTGAGTACTC TGGCTTTCAATATTGGTTAAGAAAGTAACTTTCTAATGTTCTCATCACAAAAATGTTAAATATTGGTGGC AATAATATATTAATTAGCTTAATTTAATCACTCCACACTGTAGTCAAAATCATAACACCACTTTGTACCC CATCAACATATACTACTATAGCGTGTCAATAGGCAATAAAAAAATAAAAAGAAATTTAAAGCTGGTACCC TCCCAAAAAAGAATAGAACACACTTCAAAGCCAAGTATAAAAGGTTTTTTAATTATTCCTCATTTTGCAT GATGTTTGGCAAAGGTCCTTGTTAGCCCACATGATTAGGAATCCACTTTACTTGGAATGGACTGAGAATG TCAAACTTCTAGGTTAACCAGCCATTTTTTTTTTTTCATTGATTCATTGATACATGACAGACTTGGAAGC CACTCGCTCTCTCAACCAGGGTTTTGGGTTGATCAAGTAGATGTTATTGTCACAGCTCAATGAATACTTC TTATTTCTCATCTGCCTAAGGCAGCCCTGGTGTTCAAACATATCCTTGTTTTTCCTCCAAACACACGATG CTCTGAGAATTTACACCATTAGGAATAATCTCCTACCCTCAACTCTGGGTGTATAGGGATTCAAGATTTC CTTTGTATATAGCAATTTTCCTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTT TCTTTCTTCCTTTCTTTCCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTT TCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCTTTCTTTC TTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTT TCTTTCTTTCTTTTGATGGAGTCTGGCTCTAATGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCCCAC TGCTACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGACCCCGAGCAGCTGGCATTACAGGCGC CTGCCACCATGCCTGGCAAATCTTTCTATTTTAGTAGGGATGGGGTTTCACCATGTTGGCTAGGCTGGTC TTGAACTCCCGACCTCAGGTGATCCATCCGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCA CAGCGCCCGGCGCCTTGTATGTAGCAATTTTCTATTTAAAAAAAAAAAAAAAAGACAGACTGATAAGGGT CATTGAGCAGCCGGCAAAGGATCCTAGGGAGAAATTGTCATTGCCACTTAATTTTCCAGGCCCTGTTTGG GATCTCCTTCTTTGGGATGACTTCTCTGAATCTCTCCTTATCTCCTCATGCCTTAACCCTCTCCCCCACT GGGATAGGTGCCCCTTTTCTGAGCTGCCTTATCATCCTGCCTCTGCCCTTGCTTGACATTCTGAATTGTT CATCAGTGATCTACTTGTCTGCACCCACCTCAAGACTGTTGTTTTAGAGAGCAAGGACTTTTTTTGGTTC ATTGTTCATTCCCAGAGTCTAGTACAGCTCTTGAGATGTAAGAATTACATCATAATTGTTGGTTGAGTTT ATCAATGAATAGATGCTTCAGATTCCATCCGTTTCTCTCCACTGGCACCAATCTCTCTGGCTTGTTTTCC TGTGACATTCCTGGGCAGGGATCCTGCAGAGTAGATAGAAAAGGCCTGTGTCTATCATGGAACTTGTCCC TCCCAATTGGCTTGTACAGGCAGTTATGTCACTACAGATCCTCATTTTAATTGGATTAAGGTATTCTCCT CTGAGAAGTGAAAACAGCATATAATTTACAAGGGATATTAGGTGGAGTTATAAAGTGTGAAAGTATTTGT TCTGTTTTGTTTGAGACAGAGTCTCGATCTGTCACCCAGGCTGGAGTGCAGTGGCACCATGTCATCTCAC TACAACCTCCACCTCCTGGGTTCAAGCGATTCTTATGCCTCAACCTCTGAAGTAGCTGGAATTACAGGCA TGAGCCACCATGTTCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGACCAGGCTGG TCTCAAACTCCTGCCTTCAAGTGATCCTCCCGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGTGTAAGC CACTGAGCCTGGCCTAGAGTGTGAAAGTAGAAAGGACCTTAGAGGTTACAGGATCCATCCCTCTTATTTT ACAGATAAACCAGGCTCAGAGGTGGAAAGATTTGTCCAAGCTCTCATGATTAATTCATGGCTAAGGAAGA TATCCATTGCTTTAGCCTGCCTCAGGCCCTGTGGGGAATCAGCCCTTCCCACTCTTGGTCCTAGCATTTT GGCTGGTGCTGACTTTACTCCCAAATCCAGGATGAGCATGAGAACTAGGCCTCTTCAATCAGAGCACCAG GACTTATGTTCCCAGAAGGCCAATCAAAGCCAGTGAGACATGATTTCAGGACATTGGAAAGAGAAGTTTA TGTGCTCCATTGGGGTTGCTGAGAGGATGAGATTCAAGCTTGAGACTGTAGACAGCCATCTTGTCACCAG AGGCAGACAGCCAAGGGAAGCAGTACCAAGAGATGGAGAGAATGAAATCCAGTTTTCTTGGTTTGGCACT GAGGTCTCTCATAATGACATCATTGGAGACCCTGATACAACCATGCCTGACCTCTGATCTCTGTAGGAGC TAATTAATTACTGGGGTTTCTGTTTATTTCTTGCTCAGTCAAGTTTCTGTCACTTTCCACTAGTTAGCCT AAAGAATTCAACATTAGACCTAGAAGCAGGCTTCTTAACTTTCAAATGCTGTCCTCTTTCCACCAAACCA CATCGGGCATTCCTCTGATTAACCCAATACCACCCACTGTCACATAACAGAGAGCAGAATTAGGCAGGAA TGGGAGACAATGGGCTGCATTTCAATGGGCGGGGGTATGTGTGCATCCAGTGACGTGCTCCGGGGACAAG TGGGAGGCATGAGGCCATGGGGTAATGAAAGGGTTACATCAAAACAAACTTTGGCTGCTTCCCTGTTTTA ACCCTGGCAGTCTAATGAATAAGAATTGGCGGGCAGGAGATGGGGAAGTACATGTGACTAGAAGCTGATT CAGCTGGATGTTTCTTCTCGATTAATGAAAAAACCTTTTGGTCTGGACCTGGCAAAACCAAAAGTCAAGG CATCACTGTTTTATTGTTAACCTCTCATGACTCACCTAAGGCATGGGAATATACAAGGCTACAGAAGAGT CACAGCCTTAATCAACAAACATTATGCAAACCCAGTACTACCGAGGTGGCTGTGCTGGGCCGTGTCCATT GATGGGGATCAGGCAAACAATTATATCACTGTGATATGCTAAGCAGACTGTCTTATGCTTTGGGGATAAC CTGGTTGCAAGCCTCTGAGATCAGTTCTTCATTACCAGGTGCAATAAGCAGGAACAGAAATTGTGGGCCT GTTCCTGGTGGGAATCCCATACTAACCACATCCCAGGGTGGGATTTTTAGCAATCTGCTTTCTCCTGATT TCCCCCTCTTCTCAGGTACTGATAAATTTCAACAACCAGCTAAACTAAACTAGGGTGTGGGAGTAGTGAC TTGGAGAGGACAGGAGAGGGGTTCCTGGAGTCTTGGTGATGTTGAGTTCCTAAACTGTGCTGCTTCTATG GAGATGTTCAGTTTGTGAAAATTTATTGAACTATGCACCTATGAATGTTGTATTTCCTCTAAGTATATTA TGTCTGAATAAAAACACCACAGTATGTTAAATGCTGTTATTGTAGGCAATTATTTGGCACTGTGGAGGTC TTAGAAATAAAATTAAATGGGGCCACTGAAATTATGTGATAATACTCTTCCACTCTAAAGTGGCCATACA GATACTCCACATATTTATATTTACTTCAAAATATGTAATAATCAAAATGAACATATAAATGTAAAAAAAA AAAATAGAGTTTTCACAATCTTCCAGGAGCCTAGGATACTGGTTGGGAAAGACTGAAGTATTGTTATAGT TCAGAATCACAGTGCAAGTTGACCTCAAATCCATTTACATCTCTCCACTTCCACTGCCATCACTCTAGAT CATGCCACTAGTAACTCCGGCCTGGACAGGAGCAGTACCCTCCACTCTTGCCTGATGTGTAATCCTTTGT CTACTGATATGGTCTGGATCTGTGTCCCCACCCAAATCTCACGTCAAATTATAATCCCCAGTGTTGGAAA TGGGATCTGGTGGAAGATGATTGGATCATGGGGGCAGTTTCTCATGAATGATTTAGCACTAACCCCCTAG TGCTGATGTTGTGATAGAGTTCTCATGAGATCTGGTTGTTCAAAGTGTGTGGCACCTCCCACTCTCTCTT CCGCCTGCTCTGGCCATGTAAGATGTGCCTGCTTACCCTTTGCCTTCCGCCATGATTGTAAGTTTCCTGA GGCCTCCCCAGAAGCTGATGCCACCATGCTTCCTGTACAGCCTGCAGGACTGTGAGCCAATGAAACCTCT TTTCTTTATAAATTACCCAGTCTCAGGTATTTTTCTTTATAGCAGTGTGAGAATGCACTAAGACACCAAC CCAGTAGAAAATCAGAAGATGATAGTTTTTAAATATGGCTCAAATTACTCTCCTTTCCCCCAGGCCTCCC ACCCAAGCCCTTCGAAGACTTCCTGACACTCTTAAAGTCCAAATCCTTCTCCATGGCTCACTGTGTCCAT CCTTGACCAGTCCCCACCTGCCTCTCTGACCAGCTGCCCACCACCCTTCCCCAGCTCACCAGTCTCAGCC CCACTGGCCTCTTTTCATTCTCCCAACACCACATGCCTGTCCTAGCCTTAGGGCTTTTACATGTATGCCT CTACTGCCTAAAATAGAAGTCTCCCAGATCTTTGGATTGCTGGCTCCCTCTGATTCCTTAGGTCCCAGCT CAAATATCATTCCCTCGAGTAGCCCCTCTCAGCCATTCTATGTCATTGTCTCACTACTTTACTTTATTTT CTTCACTGTATCCAAAGCTATTATGTTAATATGGTTGTTTACCAGAACATAAGCCCCATAAGGGCAAGGA TGTTGTCTACCTTGTTTATGGTTTGTATCAGTCAGGGTACCAGCAAGGCGTCTCACTATGTTGCCCAGGT TGTACTTGAACTCCTGGGCTAAAGTGATCCTCCCACTCAGCCTCTAGAGTAGCTGGGCCTGCAGGCACAC ACCAGCACACCCAGTGAGATGGCATTCTTAAAGGAGTTTAACTGAAGGGAATTTGAGAAAGGAACCAGGT ACAGAAACGTGGGCAGGGTTAAGAGAACACATGATGCGGCACCCAGGGCCTACCACTGTGGAAAGCTATC CCCACCGGTAGAACTGAAGGGGCAAGAGTGCAGAGCTGTGTTTGGAGATGGTAAGAGCGGAGGCTATGGG AGAGGAGCTACCCACCACAGCCATGGCAACGCAGGGGACAAGCGGTGACTGGGTAAGTTGCCCCGCTTCT TCCTCCTCCCACCTTCAGATTTCCTGCCATTATTTCCTGGCCAAGCCCAACTGGAAGCCAGAGAGCAAGA GAGCCTTACACAGTCCATAGGGGTCAGACTCTGGGGCCCCAGAACAGGGCAGGAAGGGTGGGGCACAGGG CAGGATCGGAGCAAACAGAGCCTAGCCAACCCTACATTGCTTGCTACATAGGTGCTCCCACATGCTGATT AAATGAATGGTTGATCGAATGAATGAATAAATGAACAACAAAGAAAGCTGAAGAGAAAGACAAAGGGATA TCCACAGGAATTAACATTTAGGAAGCTCCTAGTGGGTGCCATGTGGGCATCATATATAAATAATCTTGTT TAATCCACACAGGAATCCTATGAGATACCTTACTGTCCCTGTATATGGCTGATGATCCTGAGACCTTAGA GGTTACCATACCCTATTAAAGAGAAATCATGGAGCCAGGATTCCAACTGAGGTTCCAAGTGTTTTTCCCT TGCATTACACTAAACATATATTGCATGTTTCCATACTTGCATCAGCCTGGAACCTGCATCCCTCCCATTC CTGCCTGGAATGCTCTATAGCCTGCCTAAATCCCAGTTAACTTCTGGTTCAGCTCATGCTCCTCCTCTTC ACAGCCTGCCCTGGATCACCACAGCCAAAGGTAATCTTTCTCTCTTCTGGATATTATAGCAACTGTTATA TATCTTCACGTTTCAATTGCCATCTATTTCTTCATAATCTAATTATTTGAGAGCTTCTCATCTCCTCAAC TATATTGAAATATCTTGGAATTGGAAATTTTTGTGTTTTCTTTTGTCTATTACTTTGTATCCTTATTGCA GGTAATCAATAAATATTTGCTGGTTTACTTACCTGTCTTATATAACTCATTTTCAATGTCTTTTTTTGTT TAAGAAAAAAAATCACTTAAATGATACATTTTTACATATACTGTATAAACAACTTGTATCATTTTCTCAT TTAATATTGGATCATAAGTATTTTTTATTACACATAATTTGTAAACAATGTTTTGATGGTAGTCTAATAG TCAATTCTATGGCTGTACCAAAATTTAAATCATTTTCTATTGTGGACATTCGGGTGGATGGCATCCCCCA TCGCCTCAATATCAATGTTGTCCTGAAGAGTTTGGAGCTACATTTCTTTTCTTTTTTTCTCTTTTTTTTT TGAGATGGAGTCTTGCTGTGTTGCCCCAGGCTGGAGTGCAGTGGCACGATCTCGACTCACTGCAACCTCC ACCTGCCAGGTTCAAGCAATCCTCCTGCCTCAGCCCCCCAGTAGCTGGGATTACAGGCATGCACCACCAT GCCTGGCTAATTTTTGTATTTTAGTAGAGTCAGGGTTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCCT GACCTCAGGTGATCCACCCGCCTCAGTCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGG CCTGGAGCGACATTTATTCCTATGGAATCAATTTCCTTCACTAAGCTCTTTTTTAGGGAATGCTTAGTGA AGATTTGATTAAACACTACAATTGTTAACTACACCAGATAAGTTTAACTTTGACACTCTATTTTGTAATT CATCTTGTAATGGAAGAGTCAAAATAACAGTGTCTCCTGGTATATGCAGATAGATGGATACCTTTGGGAA GCCCACTCATTCATCTATCCATTCGTCCAGCCATATCCATCTATCCAAGTCTGCACTACTTGGGAGCCCA GGTGAGGAGAGCTGCAGTCATGATGGGAGGTTGGTGGTCTTCTCTGAAGATGTAACATTTCACCATCTTC AGTGCAACTCTTGTCCTTTGGCGACCAAGAGCTGAGCATATACGTCCTCGTGACTGTTCCAACTCCTAGT CAAGACTATATAGATTCCATGTATCATTATACTGATCACCTATCTAGACATCACAGTAGTTTTTGAGATA CCTAATTGAAATGACAACTTTTGTTAGTATTTAAAATACCAAACTGTCTTTCTTTAGCATCAGAAAATCC CCAGTTCTGTTTCTGAAGTTGCCTCAAAGCACCTGAGGGGATGTTGGGAAGGGAAATTACACAGACTGTC TATCATGGATCAGAAGCTTGTACTGCAAGCATAATGCATTGATTAAGAGAGGTGAAATCTGAATCCAGAT TGCCTGGGTCTAGGTTCAAATCCCTGCCCCACTTCTTCATGACTGTATGACCAGAACAAGGTTACTTAAC TTCTCTCTCTCCTTTTTTTGAGACAGAGTCTCACTCTATCACCCAGGCACAGTGGAACAATCATAGCTCA CTGCAGCCTCGAACGGTCAGGCTTAAGAGATCCTCCTGCCTTAGTCTCCCCAGTACCTGGGACCACAAGC ACACACCATCATGCCCAGCTAATTAAAAAAAAATTTTTTTTTTGTAGAGATGGAGTCTCACTATGCTGTT CAGGCTGGTCTTGAACCCCTGGCCTCAAGCAATCCTCCCACCTTGGCCTTCCAAAGTGAGTGCTAGGACT ATAAGCATGAGCTGCCATGCCCAGCCTACTTAACACCTCTTATCCTTACTTTCTTTATCTGTAACATAGA GGTAGTAATTACACCTCCCTCATAAGGTTGTTCTGAGACTTAAATCAGTTAACATATGAACACCAAAGTG GTGAAGCGAGCAGAATAGTGCCTGACACATATTAAGTGTGATGTGAGTACTTGCTATTATTATTACTGAT CTTATTTTAAACTCATTTAATTTAGTTCTTACAACAACTCTTACTTAGATTGAGGCTGAAAATTGTCAGC CTGTAGGTTGAACTTGGCCTGCAGATATGTTTTGTTTGGCCTGCACAATTTTCTTTAGTTTGAGCCAACA TTTAAAACTCTGGAGTTTTATACAAAAATCTTGATTTCTGGCTCTTCTTGTAAAATCCTTATCTGACAGC AACCCACAGGAGCTGAGGGCTGCTGATTTCTTTAGATAAGGAATGCACCTTGGTAGTGTGCCCTGATTCT GTGGGGATGATGTCAGTGGTGAGTGATAGAAGACCCAACTAATAGTCGCTTCAACTAAGAATTTATATCT CAATTAAGAGGTCTGAGGTAGGGTAGTTCCAGGTTTCATACAGAGGCACAAAAGTGTTGTCGGAGACTCT TGCTCCTTTACTGTTAATGTCTTCCACCTGTCCTCTCTGACATCATTGGCATGTCAGCTATGATGCTGCA CTCATACCTACTGATGCCTCCAAAGGCTCACACATGTCACATGCAGATACACGACCAGTGAAGAAGAGAT GTCTTTTTACTGGTCTCTTTTCCTTATAAAGGAAACCTTTAAAACAAAACAAAAAAACCCTAGCTGAGTG TCTCCTGAGCTCACAATTGGCCAAGACTGGCTTCTATGCCAATACTCTGGTTGGAAGAAAGCCTAGGAAA GCTGGTCTCACACTTCCTGCCCTTAAGTGGGAAGGCAGGATGTGCCTATAAGAGGGATGAGGCAAGGGGT AGTGAACAGGCCAAGACTGCCAGGCACATCTCACTCAGAAATCGCTCAAGCACACACACCCAGCTTCCTC CACCTATTTACCTAACTGAGGGCAACTGGATAATGGAATCTGTATGTCAAGTTCAGGATTCAGCCCTATA AACTTATGGAAGGTTTGAGCCATGACTAGTTTAGGTGGATTTTTTAAAATAAAAAAATCACTTTCAGTTC TTAAAAAAGGAATCCATTTTAGGTTCAAAGTAGCATGATAACTTTGCTGTTTAGAGTTTGAAATTCAACA AGGATATTTACTCTTGCCTGGATAACCTGCAGCACTGATAGCATTTGGCTCTTTGTCCCCACCCAAGTCT CATCTCGAATTGTAACCCCCAAATGTCAGGGAAGGGCCTGGTGGGAAGCAATTGGATCATGGGGGCAGCT TCTCCCAGGCTGGTCTCGTGATAGTGAGGGAGTTCTCACGAGATCTGATGGTTTAAGTGCCAAGAAGTTT TCCTCCTCTCACTCACTCCTTTCTCCTGCTGCCATGTAAGACGTGCCTTGCTTCCCCTTCACCTGCAGCC ATGATTATAAGTTTCCTGAGGCCTCCCTAGCCATGTGGAACTGTGAATCAATTAAACCTCTTTCCTTTAT AAATTACCCAGTCTCAGGGAAGTTCTTTTTATTTATTTATTTATTATCATTATTTTTTAATTTATTATTA TTATACTTTACGTTTTAGGGTACATGTGCACAATGTGCAGGTTAGTTACATATGTATACATGTGCCATGC TGGTGTGCTGCACCGGGAAGTTCTTTATAGCAGTGTGAAAACGGACTTACACAAGCACCAACCAATATTT ATGGTGTCTCTGGGTGAACATGTAAGATGCCATTTAAAATGCTGTATAGAGACATGGGCACTACCCTCTA GGTACTAGCTGTGGTCTAAATGCATCCTCTAAAATTCACAAGTTGACATTTAATCATGAATTTTTTTTTT TTTGAGACAGGGTCTCGCTCTGCTGCCCACGCAGGAGTGCAATCGCGATCTCAGCTCACTGCAACCTCCG CCTCCCGAGCTCAAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGCACACACCACCAT GTCCAGCTAATTTTTGTATTTTTAGTAAAGACAGGGTTTTGTCTTGTTGGCCCGGCTGGTCTTGAACTCC TGACCTCAGGTGATCACCCACGTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCCCACCCAG CCTGAGCCACTGCGCCTGGTCTTAATCACGAATATTAATAGGTGGGGTCTTTAGGAGGTAATTAAGTCAT GAGAGTGAAAGCCTCATGAATGGGATTAGCCGCCTTGTAAAAGGTCTGGAGGAAACTAGTGTTTGTCCCT TGTTATCCTTCCATCCCTTCCACCACATGAGGACACAGAGGTCAAGGTGCCATCTTGAAAGCAAAGACTA GGCCCTCACCAGACACGAAACCTGCCAGCGCTTTGACTTTGGACTTCCCAGCTTCCAGAACTATGAAAAA TACATTTCTGGCCAAGCGCAGTGGCTCACGCCTGTAATCCCAGCACTCTGGGAGGCCAAGGCGGGTGGAT CACGAGGTCAAGAGATTGAGATCATCCTGACCAACATGGTGAAACCTTGTCTCTACTTAAAATACAAAAA ATTAGCCAGGTGTGGTGGCAGGCACCTGTAGTCCCAGCTACTAGGGAGGCTGAGGCAGGAGAATCACTTG AATCCGGGAGGCGGAGGTTGTAGTGAGCCGAGATTGCACCACTGCACTCAGCCTGGCAACAGAGAGAGAC TCCATCTAAAAAAAAAAAAAAATCTATTATGTGTTAATTACCAGTTCTTAGGTGTTTTGTTATAGCAGCA CAAACAGACTAAGACAATACTCATCACCCAAGTCACTCTGGAAGGCACTGTTTTATAAGAGCAGAACAGA GTGTGATACATGAATGCTGCAGGCATCAGAAATTGCTGGAACCCATTAAGTTGCTCCCATTAAGTTGGGG GCAGGGTAAAATAAGTAGAAGTACACAGTATGCCACTGTGTGGGCAAAGTTGTTTCTGATTTCATACTAA AGATAGAACCCTAAAACAAGACCTAACAAGAGGTTTCTTTGTGGAAACAATCTTCTTGGGTTAATAGCTA AATATAGTGACTAATGCTTCTTCCTGTTCTTTCTCGACTATACCTTATGAGCTACCTTTAGAACAAGCAG GTTGAAGCCCTGCCTTTTACTAATCCCCTGAGATAATCTTTTTAAAACTCTCAGTGGCAAGTGAAGACCC CAGTGTTTTCCCCATCTCTGAGATTTCTTTCATATCCCTTTAGCATTCGCATTTGCTCTTACTGGTTATT TCCCATGCTGAATCATTCACTGACTATCTGGTCATCTCCTGGGGGAGCCAAATAGTTTTAAACATTCTCA GTGACTCATCTATCCTCACCAGTTCTTTTATTTATTTGTTGTTGATGTGTCATACACACACAATCTCTCT CTGTCATTAAAATGCTAAAAAAAGTTTCTATTTACCGTCATAGTATACTCCACTTTCTCAGTGCATGTCT TCACTTGTTTTGTAGTTTTCTAGTTCATGCAATTGAAATAAAGGTACAGTTACTTAGTCTTTAACCAAGT CCCAGGTTTAGCCAAAATTGTCAAACTCAGGATTCAGCCCTTCAAAGCTTACGAATTTATTGAGGGCCGG GCGCGGTGGCTCACATTTGTAATCTCAGCACTTTGGGAGGCCCAGGCGAGTGGATCACCAGAGGTCAGGA GTTTGAGACCAGCCTGGCCAACATGGTGAAACCCAGTCTCTACTAAAAACACAAAAATTAGCTGGGTGTG GTGGCACGTGCCTGTAATCTTAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGG AGGTTGCAATGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGCAACAGGGTGAGACCATCTCAAAAAA AAAAAAAAAAAAAAAGAGAATTACTTGGTGAAAATAATTCCATATCATTACTATTTTGTAAAAGGGAAAC TGCTCTCTTAGCACATTGTGTTGTTTGCTTTGCTACCTTCAGTTGCTCTGCGTCAGAACCCTGTATCTGA AATCCCTCAATAATGAGACTAACTGAGGTAGTGGTGATACTCTATCTTGTTATTTTAAAGCAGGCCTGCA AATACTGGGTGCTCAGTAACCATGAGAAAAAGGCCTGATAAAAGCAACAACAGAAGCAATTGGGACCCAA GGTGGACACCACGGCAAATCCTCAGCGCCTGGGTTTTAGACGGTTCTGCCAAAGGTTTGGTTCTTTCCAG CCTGAGATCATTGCTTAGATCTTTCTGGGGTGTAGTTAAAGTAAAATGAGCCTCTTTCTATTTATCCCAC AGATGCCGTTCTCTCTTAACAATGTACTCCTTGAAGGCTTCTTAAGGTAATGTCTGGTCTCTGCT Download Select all
Length	56415
OMIM ID	605117
HGNC ID	HGNC:19382
Unigene ID	Hs.485572
Ensembl ID	ENSG00000120833
PharmGKB ID	-

mRNA Information

mRNA ID	NM_003877.4
Exon	join(1..377,2864..3215,4901..6924)
mRNA Sequence	>8835 ACCTGATCAAGGGGACCGCCTCCGGTCCCCGGCCGTGGGCACCGGGACGAGCACGGCGTCCCCA CGCCATCGATGTGTCTTAGAGCCGGAGAGTCTGGTTTCCGAGGACCCACAGTCGCTCCTGCACG CCCACCCCCCGCAAAAGTGCGGCCAGGAGGGTCGCATCGAGGGGGCGCCGCCGGGATGTTTAGA GGAACCCACCCCCGTGGCAGGCCAAGGGCCAAGGATCGCTATCCTTCCCTGAACCCGGGCGCTC AGCTGGCCCGGGCGATCAGTGGGTGACCGCGGCTGCGAGGGACTTTGTCATCCGTCCTCCAGGA TCTGGGGAGAAAGAGCCCCATCCCTTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTC GTTTTGGGATTCGCACTGACTTCAAGGAAGGACGCGAACCCTTCTCTGACCCCAGCTCGGGCGG CCACCTGTCTTTGCCGCGGTGACCCTTCTCTCATGACCCTGCGGTGCCTTGAGCCCTCCGGGAA TGGCGGGGAAGGGACGCGGAGCCAGTGGGGGACCGCGGGGTCGGCGGAGGAGCCATCCCCGCAG GCGGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGATGGTACTGGGGAAGTATGA CTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTTCTTGATTAGAGATAG CTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGACCAACTAATCTTCGA ATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGTGTCAAATCCAAGCTTAAAC AATTTGACAGTGTGGTTCATCTGATCGACTACTATGTTCAGATGTGCAAGGATAAGCGGACAGG TCCAGAAGCCCCCCGGAACGGCACTGTTCACCTTTATCTGACCAAACCGCTCTACACGTCAGCA CCATCTCTGCAGCATCTCTGTAGGCTCACCATTAACAAATGTACCGGTGCCATCTGGGGACTGC CTTTACCAACAAGACTAAAAGATTACTTGGAAGAATATAAATTCCAGGTATAAATGTTTCTCTT TTTTTAAACATGTCTCACATAGAGTATCTCCGAATGCAGCTATGTAAAAGAGAACCAAAACTTG AGTGCTCTGGATAACTATATGGAATGCTTTCTAAGAACAGCTGAAGCTAATCTAATTTAAATTT AACAGCTTGAAGAGGTAGCTAGGTGTTTAAAGTTCCTCCAGATACTTTTACCTGAGTGATGCTT CCCTTCCTAAGGCTGACCAAGACCTGTTGATCCTTTTAGATTAAAAATAAAATGTCGCATGTAA AGGCTGAAGTCGCGTTTTATCAGAATGCCTTGCCTTCTTAGGTTCTTTTCCATTATGTCAAAGG TCCAGGCTCCAGTAGGAGAGAAAGAACTCCTCATAGGAATACTGAAGAAGTGGGAAGGAACCAA GCTGACACAGGCCTCACTGCAATTTGATATGCCTGCTGATCAGAGTCTCTTGGGCATTTTATAT TTTGCATTCTGATGTACCTAGGAGTTTTGTTAAACAGATGATGTATGTGAGTATTTATCCCATT TTATGCAATTAACCAAATCAACCAAAAAAAGTGACCATGAAGTCCTGTATTTGTCTTTTTACTA CATGTAGGAACTCTCATGTGAATGAGTACTGTAGTAATCCATTCTATGGGAGCCTTATTTCAGA AATATTTCAAACTGGTGCAAATGGAAAAGACTTTCTCTTTTCCTTTAAAGCTAAAGACAAGAAT ATCATGCTATACAGGTGCAACTCAATCCCCGTTAATAAAAACCAATGTAGGTATAGGCATTCTA CCCTTTGAAATAGCTGTGTCCCAACCTGTTGCCATTGATTTTTTGGAAATGGCTTTAGAAATAT CCAAGTTGTCCTTGAATTGTCTAACCATGGACATAAACAGTTGTCTCCCTTCTACTGTGTAGAA TACTTTGACTTAATTTTCTTCCAGATACAGGGGGATACCTGCCTGTTTTTCAAAGTGTTTATTT ACTGCTGTTACTATTTGATTAGAATGTATTAAATAAAAAAAACCTGATTTCTACAAGTTGCACT TATTGAGTTCTAGAGAACGTACACTTTCATGGTAATAGAGGATTGCCATAAAAACTTACGTCAA GTGAAATAAGCCAATTATTCAACAAAAGGTAGAACATTACTTGCCATTCTGTAAAGTTATGGGC TGTACCTGCCCCCTTTGCAATTTGGAAAGCATGGTTTAGAAACTACAGGCATTGTCAAGTGGCC GGGTCTTTTATAATTTGAATAGGCATAACACTGATGTCCTCTGTGTTTCCAAAAACATGGTTTA GAAACTACAAACATTATGACATGGCCAGTCTTTTACAAGTTGAGTAGGCATAATACTAAAGAAA AATACAAAGTTTTGTGGCCACTTATTTTTTGCTATGTTAGTCTGCATAACTGTTATAAATGTAC CATCTTTTCTAGAGTCCAGACATTATTTATTTTATGGCTTTAAAATTTTCCTGCATAGCTACAA TCCTGTGGTGTGTCACCATAAAGGTGGACCCTGTGTGAATGAGAAAATTCAGTTATAAATTGTA ATAAAACCTGCTTACTGGAAAAAAA Download Select all
Length	2649

CDS Information

Location	join(3077..3215,4901..5352,56353..56400)
CDS Sequence	>lcl\|NM_001270467.1_cds_NP_001257396.1_1 [gene=SOCS2] [protein=suppressor of cytokine signaling 2] [protein_id=NP_001257396.1] [location=481..1077] ATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGGGGAAGGGACGCGGAGCCAGTGGGGGACCGCGG GGTCGGCGGAGGAGCCATCCCCGCAGGCGGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGG ATGGTACTGGGGAAGTATGACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTTC TTGATTAGAGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGACCAACTA ATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGTGTCAAATCCAAGCTTAA ACAATTTGACAGTGTGGTTCATCTGATCGACTACTATGTTCAGATGTGCAAGGATAAGCGGACAGGTCCA GAAGCCCCCCGGAACGGCACTGTTCACCTTTATCTGACCAAACCGCTCTACACGTCAGCACCATCTCTGC AGCATCTCTGTAGGCTCACCATTAACAAATGTACCGGTGCCATCTGGGGACTGCCTTTACCAACAAGACT AAAAGATTACTTGGAAGAATATAAATTCCAGGTATAA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001257396.1
Protein Name	suppressor of cytokine signaling 2
Molecular Wt. (Da)	22041
Protein Sequence	>8835 MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKE APEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDY YVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLE EYKFQV Download Select all
Length	198
Uniprot ID	P12268
Ensembl Protein ID	ENSP00000321584

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2057	EPOR	587	NP_000112.1	in vitro;yeast 2-hybrid	1 178 157 315 644 410
2690	GHR	2971	NP_000154.1	in vitro;in vivo	10585430
3480	IGF1R	932	NP_000866.1	in vitro;in vivo	9727029
5618	PRLR	1457	NP_000940.1	in vitro;in vivo	104 551 129 202 403

Pathway Information

Pathway Name	Pathway ID
Insulin signaling pathway	hsa04910
Jak-STAT signaling pathway	hsa04630
Prolactin signaling pathway	hsa04917
Type II diabetes mellitus	hsa04930

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd10383	40-142	SH2_SOCS2
cl15255	40-142	SH2 superfamily
cd03736	158-198	SOCS_SOCS2
cl02533	158-198	SOCS superfamily
cd10718	43-130	SH2_CIS
cd09923	47-130	SH2_SOCS_family
cd10382	38-134	SH2_SOCS1
cd10384	39-133	SH2_SOCS3
cd10387	37-139	SH2_SOCS6
smart00252	48-131	SH2
cd10388	39-137	SH2_SOCS7
cd09942	41-129	SH2_nSH2_p85_like
cd00173	48-129	SH2
cd03717	158-194	SOCS_SOCS_like
smart00969	161-194	SOCS_box
cd03734	158-198	SOCS_CIS1
cd03587	159-194	SOCS
smart00253	154-194	SOCS
pfam00017	48-129	SH2
pfam07525	161-191	SOCS_box
cd09940	48-129	SH2_Vav_family
cd10385	40-108	SH2_SOCS4
cd10409	46-156	SH2_Nck2
cd03716	161-191	SOCS_ASB_like
cd10386	49-108	SH2_SOCS5
cd10356	40-110	SH2_ShkA_ShkC
cd10391	48-156	SH2_SHE
cd09931	48-158	SH2_C-SH2_SHP_like
cd10352	49-131	SH2_a2chimerin_b2chimerin
cd09932	48-129	SH2_C-SH2_PLC_gamma_like
cd09937	48-129	SH2_csk_like
cd10408	48-156	SH2_Nck1
cd09945	47-156	SH2_SHB_SHD_SHE_SHF_like
cd10357	48-101	SH2_ShkD_ShkE
cd09926	48-85	SH2_CRK_like
cd03739	162-197	SOCS_SOCS5
cd10392	48-156	SH2_SHF
cd09925	41-131	SH2_SHC
cd09929	48-132	SH2_BLNK_SLP-76
cd09934	48-129	SH2_Tec_family
cd03741	162-193	SOCS_SOCS7
cd03738	162-197	SOCS_SOCS4
cd03730	158-194	SOCS_ASB14
cd10348	48-131	SH2_Cterm_shark_like
cd03723	162-191	SOCS_ASB4_ASB18
cd03733	159-191	SOCS_WSB_SWIP
cd10406	48-129	SH2_Vav2
cd09941	48-129	SH2_Grb2_like
cd10361	48-132	SH2_Fps_family
cd10405	48-131	SH2_Vav1
cd10389	48-156	SH2_SHB
cd03746	159-191	SOCS_WSB1_SWIP1
cd09943	48-129	SH2_Nck_family
cd10407	48-129	SH2_Vav3
cd09930	48-87	SH2_cSH2_p85_like
cd10365	48-131	SH2_Src_Src
cd03740	162-196	SOCS_SOCS6
cd10341	57-132	SH2_N-SH2_PLC_gamma_like
cd03737	158-194	SOCS_SOCS3
cd10337	41-130	SH2_BCAR3
cd03722	159-191	SOCS_ASB3
cd09918	53-91	SH2_Nterm_SPT6_like
cd10398	48-129	SH2_Tec_Txk
cd10354	48-98	SH2_Cterm_RasGAP
cd09933	48-84	SH2_Src_family
cd03725	158-191	SOCS_ASB6
cd09927	48-101	SH2_Tensin_like
cd03729	162-191	SOCS_ASB13
cd10369	48-129	SH2_Src_Frk
cd03745	161-191	SOCS_WSB2_SWIP2
cd10370	48-84	SH2_Src_Src42
cd09935	48-129	SH2_ABL
cd10397	48-91	SH2_Tec_Btk
cd10380	51-129	SH2_Jak3
cd10347	48-84	SH2_Nterm_shark_like
cd10396	43-91	SH2_Tec_Itk
cd09919	29-75	SH2_STAT_family

Ontology Information

HPRD ID	935
Molecular Class	Adapter molecule
Molecular Function	Catalytic activity (GO:0003824)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO

CoReCG

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General Information

Evidence Information

Gene Details

mRNA Information

CDS Information

Protein Information

Post-translational Modification Information (Source : HPRD)

Enzyme Information

PPi Information

Pathway Information

Structure Information

Domain Information

Ontology Information

SNP Information

Drug Information

External Links

Important Information