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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| WISP2 | 8839 | WNT1 inducible signaling pathway protein 2 | 20 | CT58, CTGF-L, CCN5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20372786 | 2010 | Cell line : - Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 94 CRC tumours and 80 normal tissues Stage : TNM Stage I-IV. | - | Down-regulation | - | WISP-2 showed the opposite pattern with lower levels of expression in cancer cells compared to normal. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q13.12 |
| Start | 43343493 |
| End | 43356453 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12961 |
| OMIM ID | 603399 |
| HGNC ID | HGNC:12770 |
| Unigene ID | Hs.592145 |
| Ensembl ID | ENSG00000064205 |
| PharmGKB ID | PA37373 |
Protein Information
| Protein ID | NP_003872.1 |
|---|---|
| Protein Name | WNT1 inducible signaling pathway protein 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 250 |
| Uniprot ID | Q9Y250 |
| Ensembl Protein ID | ENSP00000265801 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3479 | IGF1 | 936 | AAA52539.1 | in vitro | 10358067 |
| 3481 | IGF2 | 939 | NP_001121070.1 | in vitro | 10358067 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00219 | 42-78 | IGFBP |
| cl02472 | 42-78 | IGFBP superfamily |
| pfam00093 | 100-160 | VWC |
| cl17735 | 100-160 | VWC superfamily |
| smart00214 | 100-159 | VWC |
| smart00121 | 45-64 | IB |
Ontology Information
| HPRD ID | 9724 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Calcium ion binding (GO:0005509) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.