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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22552777 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 3 Stage : - | MIRA-based microarrays ,Combined bisulfite restriction analysis ,Significant enrichment analysis of GO | Hypermethylation | - | Methylated PHOX2B, FGF12 and GAD2 were better than methylated vimentin and SEPT9 in differentiating CRC cancer tissue from non-cancer tissue. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4p13 |
| Start | 41746099 |
| End | 41750987 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4889 |
| OMIM ID | 603851 |
| HGNC ID | HGNC:9143 |
| Unigene ID | Hs.87202 |
| Ensembl ID | ENSG00000109132 |
| PharmGKB ID | PA33467 |
Protein Information
| Protein ID | NP_003915.2 |
|---|---|
| Protein Name | paired-like homeobox 2b |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | Q9Y6W6 |
| Ensembl Protein ID | ENSP00000355866 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 99-157 | homeodomain |
| cl00084 | 99-157 | homeodomain superfamily |
| pfam00046 | 99-155 | Homeobox |
| smart00389 | 98-154 | HOX |
| COG5576 | 96-156 | COG5576 |
Ontology Information
| HPRD ID | 6149 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Growth factor binding (GO:0019838) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.