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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9885380 | 1999 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 35 Stage : Duke Stage A,B,C,D | Flow cytometry | Up-regulation | - | Neoplastic deregulation of cyclin D3 expression may provide a selective growth advantage which is related to stage in human colorectal cancer. |
| 16012517 | 2005 | Cell line : HT29, LoVo39 Source : Soroka Medical Center. Sample Type : CRC tumor and normal tissue No. of Sample : 57 Stage : TNM Stage I-IV | Western blotting,mRNA analysis,Cell cycle analysis,Alkaline phosphatase assay. | Up-regulation | - | Overexpression of cyclins D1 and/or D2, but not cyclin D3, is linked to colon carcinogenesis and that overexpression of cyclin D2 may be related to a higher TNM stage of the tumour. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
| Chromosome | 6 |
| Location | 6p21 |
| Start | 41902671 |
| End | 42016610 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 113940 |
| OMIM ID | 123834 |
| HGNC ID | HGNC:1585 |
| Unigene ID | Hs.534307 |
| Ensembl ID | ENSG00000112576 |
| PharmGKB ID | PA26152 |
mRNA Information
| mRNA ID | NM_001136126.2 |
|---|---|
| Exon | join(1..394,111501..111660,112200..112336,112788..113962) | mRNA Sequence | Download Select all |
| Length | 1883 |
Protein Information
| Protein ID | NP_001129598.1 |
|---|---|
| Protein Name | cyclin D3 |
| Molecular Wt. (Da) | 9605 |
| Protein Sequence | Download Select all |
| Length | 96 |
| Uniprot ID | O95298 |
| Ensembl Protein ID | ENSP00000281031 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 263 |
| S | Phosphorylation | 264 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 374 | AREG | 93 | NP_001648.1 | in vivo | 11469683 |
| 1019 | CDK4 | 447 | NP_000066.1 | in vitro;in vivo | 103 428 701 523 210 000 000 000 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 15232106 |
| 5596 | MAPK4 | 1497 | NP_002738.2 | in vitro;in vivo;yeast 2-hybrid | 16360641 |
| 7421 | VDR | 3463 | NP_000367.1 | in vitro;in vivo;yeast 2-hybrid | 16105657 |
| 22809 | ATF5 | 5906 | NP_036200.2 | in vitro;in vivo;yeast 2-hybrid | 15358120 |
| 30008 | EFEMP2 | 5221 | NP_058634.3 | yeast 2-hybrid | 16189514 |
| 84062 | DTNBP1 | 6190 | NP_115498.2 | yeast 2-hybrid | 16189514 |
| 84232 | MAF1 | 14345 | NP_115648.2 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Focal adhesion | hsa04510 |
| Hippo signaling pathway | hsa04390 |
| HTLV-I infection | hsa05166 |
| Jak-STAT signaling pathway | hsa04630 |
| Measles | hsa05162 |
| p53 signaling pathway | hsa04115 |
| PI3K-Akt signaling pathway | hsa04151 |
| Viral carcinogenesis | hsa05203 |
| Wnt signaling pathway | hsa04310 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 56-145 | CYCLIN |
| cl00050 | 56-145 | CYCLIN superfamily |
| pfam00134 | 26-152 | Cyclin_N |
| smart00385 | 63-145 | CYCLIN |
| pfam02984 | 155-261 | Cyclin_C |
| cl00050 | 155-261 | CYCLIN superfamily |
| COG5024 | 31-270 | COG5024 |
Ontology Information
| HPRD ID | 3786 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Ubiquitin-specific protease activity (GO:0004843) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.