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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22173670 | 2012 | Cell line : CRL-1541, CRL-1539 , CCL-228 (SW480), CCL-230 (SW403), CCL-248 (T84), CRL2577 (RKO), LIM1215, and HCA7 Source : ATCC, Mikkeli Central Hospital, Mikkeli, Finland Sample Type : CRC tumor and normal tissue No. of Sample : 61 CRC and 10 adenoma Stage : - | FISH, loss of heterozygosity, and array-CGH,siRNA depletion, expression arrays, and immunohistochemistry | Amplification | - | NAV3 has a role in linking tissue inflammation to cancer development in the colon. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q14.3 |
| Start | 78224685 |
| End | 78606790 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 382106 |
| OMIM ID | 611629 |
| HGNC ID | HGNC:15998 |
| Unigene ID | Hs.655301 |
| Ensembl ID | - |
| PharmGKB ID | PA31453 |
Protein Information
| Protein ID | NP_001019554.1 |
|---|---|
| Protein Name | neuron navigator 3 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 2385 |
| Uniprot ID | Q86TB3 |
| Ensembl Protein ID | ENSP00000354991 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1186 |
| T | Phosphorylation | 1193 |
| S | Phosphorylation | 1189 |
| S | Phosphorylation | 1071 |
| T | Phosphorylation | 1080 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00014 | 81-182 | CH |
| cl00030 | 81-182 | CH superfamily |
| cd00009 | 2052-2132 | AAA |
| cl21455 | 2052-2132 | P-loop_NTPase superfamily |
| pfam00307 | 81-182 | CH |
| smart00033 | 81-182 | CH |
| pfam13207 | 2051-2072 | AAA_17 |
| pfam13401 | 2052-2139 | AAA_22 |
| pfam02562 | 2036-2066 | PhoH |
| cl21455 | 2036-2066 | P-loop_NTPase superfamily |
| TIGR03927 | 468-545 | T7SS_EssA_Firm |
| cl11266 | 468-545 | EssA superfamily |
| pfam00910 | 2052-2094 | RNA_helicase |
| pfam00004 | 2052-2129 | AAA |
| smart00382 | 2049-2169 | AAA |
| COG5069 | 70-180 | SAC6 |
| PHA03307 | 969-1293 | PHA03307 |
| pfam06070 | 938-1369 | Herpes_UL32 |
| TIGR04211 | 1570-1646 | SH3_and_anchor |
| TIGR02169 | 1562-1648 | SMC_prok_A |
| pfam09786 | 234-469 | CytochromB561_N |
| COG5422 | 1117-1387 | ROM1 |
| pfam05110 | 204-617 | AF-4 |
| PRK13808 | 440-553 | PRK13808 |
| TIGR02928 | 2051-2137 | TIGR02928 |
| TIGR02168 | 1569-1649 | SMC_prok_B |
Ontology Information
| HPRD ID | 12484 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.