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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| NOL3 | 8996 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 16 | ARC, NOP30, MYP, CARD2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22363440 | 2012 | Cell line : - Source : Mayo Clinic, Mount Sinai, and Cleveland Clinic. Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 80 Stage : - | Cis-expression quantitative trait loci (cis-eQTL) analyses, genome-wide SNP and gene expression profiling | Down-regulation | - | The colorectal cancer low risk allele (A) for rs9929218 at 16q22.1 was associated with a significant decrease in expression of both NOL3 (q?=?0.017) and DDX28 (q?=?0.046) in the adjacent normal colon tissue samples. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| Chromosome | 16 |
| Location | 16q22.1 |
| Start | 67204400 |
| End | 67209640 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5241 |
| OMIM ID | 605235 |
| HGNC ID | HGNC:7869 |
| Unigene ID | Hs.513667 |
| Ensembl ID | - |
| PharmGKB ID | PA31673 |
Protein Information
| Protein ID | NP_001171986.1 |
|---|---|
| Protein Name | nucleolar protein 3 (apoptosis repressor with CARD domain) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 208 |
| Uniprot ID | Q13442 |
| Ensembl Protein ID | ENSP00000222968 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 149 |
| S | Phosphorylation | 104 |
| Y | Phosphorylation | 105 |
| T | Phosphorylation | 114 |
| S | Phosphorylation | 120 |
| T | Phosphorylation | 122 |
| T | Phosphorylation | 123 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 835 | CASP2 | 2800 | NP_116764.2 | in vivo | 9560245 |
| 841 | CASP8 | 3459 | NP_001073594.1 | in vitro;in vivo | 9560245 |
| 55224 | ETNK2 | 13283 | NP_060678.2 | yeast 2-hybrid | 16189514 |
| 60491 | NIF3L1 | 10424 | AAH07654.1 | yeast 2-hybrid | 16189514 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01671 | Dec-83 | CARD |
| cl14633 | Dec-83 | DD superfamily |
| smart00114 | May-92 | CARD |
| pfam00619 | Oct-95 | CARD |
Ontology Information
| HPRD ID | 11224 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.