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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24307622 | 2014 | Cell line : SW480 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 57 Stage : - | Immunohistochemistry and Western blotting | Down-regulation | - | Level of�CCNG2protein expression was significantly lower in�colorectal cancer�tissue than normal tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q21.22 |
| Start | 78078357 |
| End | 78091213 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12857 |
| OMIM ID | 603203 |
| HGNC ID | HGNC:1593 |
| Unigene ID | Hs.740456 |
| Ensembl ID | ENSG00000138764 |
| PharmGKB ID | PA26158 |
mRNA Information
| mRNA ID | NM_004354.2 |
|---|---|
| Exon | join(1..303,1330..1467,2164..2301,3518..3768,4277..4355, 4446..4544,7071..7276,8598..12857) | mRNA Sequence | Download Select all |
| Length | 5489 |
Protein Information
| Protein ID | NP_004345.1 |
|---|---|
| Protein Name | cyclin G2 |
| Molecular Wt. (Da) | 38735 |
| Protein Sequence | Download Select all |
| Length | 344 |
| Uniprot ID | Q14511 |
| Ensembl Protein ID | ENSP00000368745 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5524 | PPP2R4 | 2858 | NP_821068.1 | in vitro | 11956189 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 63-145 | CYCLIN |
| cl00050 | 63-145 | CYCLIN superfamily |
| pfam00134 | 74-153 | Cyclin_N |
| smart00385 | 63-145 | CYCLIN |
| COG5024 | 70-162 | COG5024 |
Ontology Information
| HPRD ID | 9751 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Hydrolase activity (GO:0016787) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.