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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TM4SF5 | 9032 | transmembrane 4 L six family member 5 | 17 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
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- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25268742 | 2014 | Cell line : HT 29 Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 45 Stage : - | Immunohistochemistry | Up-regulation | - | TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17p13.3 |
| Start | 4675187 |
| End | 4686506 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11320 |
| OMIM ID | 604657 |
| HGNC ID | HGNC:11857 |
| Unigene ID | Hs.184194 |
| Ensembl ID | ENSG00000142484 |
| PharmGKB ID | PA36558 |
Protein Information
| Protein ID | NP_003954.2 |
|---|---|
| Protein Name | transmembrane 4 L six family member 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 197 |
| Uniprot ID | O43482 |
| Ensembl Protein ID | ENSP00000220514 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
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Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05805 | 1-191 | L6_membrane |
| cl05399 | 1-191 | L6_membrane superfamily |
Ontology Information
| HPRD ID | 16719 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Voltage-gated ion channel activity (GO:0005244) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.