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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GPRC5A | 9052 | G protein-coupled receptor, family C, group 5, member A | 12 | RAI3; RAIG1; GPCR5A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23021913 | 2013 | Cell line : - Source : - Sample Type : CRC tissue and blood sample No. of Sample : - Stage : - | LC MS/MS, Western blotting, immunohistochemistry | Up-regulation | - | RAI3 over-expression is distinct to CC tissues (when compared to normal colonic Epithelium). RAI3 expression may be of potential value as a marker for disease recurrence in CC. The matched normal/tumour tissues (three grade 2 and one grade 3 colon adenocarcinoma and corresponding normal mucosa samples) were studied. |
| 22968445 | 2012 | Cell line : - Source : Department of Pathology of Wroc$aw Medical University. Sample Type : CRC tumor and normal tissue No. of Sample : 8 Stage : - | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | - | A list of genes including this gene are differentially expressed analysed by LC-MS/MS technique. To compare the proteomes of colonic mucosa (normal or N) and colon cancer (cancer or C), we analyzed archival FFPE clinical samples originating from eight patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class C : Orphans |
| Description | This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12p13-p12. |
| Start | 12891022 |
| End | 12913666 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 22645 |
| OMIM ID | 604138 |
| HGNC ID | HGNC:9836 |
| Unigene ID | Hs.631733 |
| Ensembl ID | ENSG00000013588 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_003979.3 |
|---|---|
| Exon | join(1..643,17222..18150,21063..21121,21426..22645) | mRNA Sequence | Download Select all |
| Length | 2856 |
CDS Information
| Location | join(17229..18150,21063..21121,21426..21518) 32116..32253,42472..42601,42811..42942,43458..43562, |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8657.1 |
Protein Information
| Protein ID | NP_003970.1 |
|---|---|
| Protein Name | G protein-coupled receptor, family C, group 5, member A |
| Molecular Wt. (Da) | 40120 |
| Protein Sequence | Download Select all |
| Length | 357 |
| Uniprot ID | P18146 |
| Ensembl Protein ID | ENSP00000239938 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 317 |
| S | Phosphorylation | 345 |
| Y | Phosphorylation | 320;- |
| Y | Phosphorylation | 347;- |
| Y | Phosphorylation | 350;- |
| Y | Phosphorylation | 300 |
| S | Phosphorylation | 301 |
| S | Phosphorylation | 336 |
| T | Phosphorylation | 315 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00003 | 40-268 | 7tm_3 |
| cl02802 | 40-268 | 7tm_3 superfamily |
| pfam05478 | 69-125 | Prominin |
Ontology Information
| HPRD ID | 554 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Serine-type peptidase activity (GO:0008236) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q8NFJ5 | DB00755 | Tretinoin | SmallMoleculeDrug |