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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
STARD13 90627 StAR-related lipid transfer (START) domain containing 13  13GT650, DLC2, ARHGAP37 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24253896   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Down-regulation-StarD13 appears to be a tumor suppressor in colon cancer as well.


Gene Details



NC_000013.10 (33677272..34250932, complement)

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Gene Type protein coding
Gene Family Rho GTPase activating proteins, "StAR-related lipid transfer (START) domain containing"
Description This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]  
Chromosome 13
Location 13q13.1
Start 33677272  
End 34250932  
Strand -  
Gene Sequence

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Length 573661  
OMIM ID 609866   
HGNC ID HGNC:19164   
Unigene ID Hs.156551   
Ensembl ID ENSG00000133121   
PharmGKB ID PA38806   

mRNA Information


mRNA ID ?NM_001243466.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS9348.1



Protein Information


      
Protein IDNP_001230395.1
Protein NameStAR-related lipid transfer (START) domain containing 13
Molecular Wt. (Da)0
Protein Sequence

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Length 1113  
Uniprot IDQ96KR7
Ensembl Protein ID ENSP00000347866  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation389
SPhosphorylation381
SPhosphorylation271
SPhosphorylation411
SPhosphorylation403
SPhosphorylation293

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
576BAI24063NP_001694.2in vivo;yeast 2-hybrid14697242   
2036EPB41L14193NP_036288.2in vivo;yeast 2-hybrid14697242   
3156HMGCR836NP_000850.1in vivo;yeast 2-hybrid14697242   
3326HSP90AB16763NP_031381.2in vivo;yeast 2-hybrid14697242   
3708ITPR1925Q14643in vivo;yeast 2-hybrid14697242   
7277TUBA4A1851NP_005991.1in vivo;yeast 2-hybrid14697242   
8887TAX1BP15618NP_006015.4in vitro;in vivo;yeast 2-hybrid14697242   
23095KIF1B5818NP_055889.2in vivo;yeast 2-hybrid14697242   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd08909900-1104  START_STARD13-like
cl14643900-1104  SRPBCC superfamily
cd04375657-874  RhoGAP_DLC1
cl02570657-874  RhoGAP superfamily
cd0959257-120  SAM_DLC2
cl1575557-120  SAM_superfamily superfamily
cd08869908-1104  START_RhoGAP
cd08907903-1104  START_STARD8-like
cd08908904-1101  START_STARD12-like
smart00324674-820  RhoGAP
pfam00620677-820  RhoGAP
cd00159677-820  RhoGAP
smart00234913-1096  START
pfam01852913-1098  START
cd0953861-120  SAM_DLC1,2-like
cd04391660-879  RhoGAP_ARHGAP18
cd00177919-1102  START
cd0959161-120  SAM_DLC1
cd04404661-818  RhoGAP-p50rhoGAP
cd04377661-818  RhoGAP_myosin_IX
cd04376676-874  RhoGAP_ARHGAP6
cd04394660-822  RhoGAP-ARHGAP11A
cd04386658-818  RhoGAP_nadrin
cd04385696-820  RhoGAP_ARAP
cd04398661-819  RhoGAP_fRGD1
cd04402661-822  RhoGAP_ARHGAP20
cd04407675-819  RhoGAP_myosin_IXB
cd04393660-821  RhoGAP_FAM13A1a
cd04383661-820  RhoGAP_srGAP
cd04373661-819  RhoGAP_p190
cd04403661-820  RhoGAP_ARHGAP27_15_12_9
cd04381661-818  RhoGap_RalBP1
cd04392673-879  RhoGAP_ARHGAP19
cd04374680-818  RhoGAP_Graf
cd04378692-818  RhoGAP_GMIP_PARG1
cd04397661-822  RhoGAP_fLRG1
cd04384660-819  RhoGAP_CdGAP
cd04395660-818  RhoGAP_ARHGAP21
cd04406661-819  RhoGAP_myosin_IXA
cd04408692-818  RhoGAP_GMIP
cd04379661-819  RhoGAP_SYD1
cd04409661-818  RhoGAP_PARG1
cd04387661-818  RhoGAP_Bcr
cd04372661-818  RhoGAP_chimaerin
cd04396660-819  RhoGAP_fSAC7_BAG7
cd04400660-818  RhoGAP_fBEM3
cd08871923-1081  START_STARD10-like
cd04390659-819  RhoGAP_ARHGAP22_24_25
cd04389696-833  RhoGAP_KIAA1688
cd04382692-871  RhoGAP_MgcRacGAP
cd04405660-793  RhoGAP_BRCC3-like
pfam0764760-120  SAM_2
cd08876946-1081  START_1
cd04380686-820  RhoGAP_OCRL1
smart0045461-120  SAM


Ontology Information


   
HPRD ID10725
Molecular ClassGTPase activating protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO