Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| USP10 | 9100 | ubiquitin specific peptidase 10 | 16 | UBPO, KIAA0190 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24332849 | 2013 | Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Chromatin Immunoprecipitation,Cell cycle analysis,real-time PCR,Cell proliferation assay,Soft agar colony formation assay | Down-regulation | - | Study discovered crosstalk between two tumor-suppressive genes in regulating cell-cycle progression and proliferation and showed that dysregulated USP10 function promotes tumorigenesis through SIRT6 degradation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ubiquitin-specific peptidases |
| Description | Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013] |
| Chromosome | 16 |
| Location | 16q |
| Start | 84733555 |
| End | 84813528 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 79974 |
| OMIM ID | 609818 |
| HGNC ID | HGNC:12608 |
| Unigene ID | Hs.136778 |
| Ensembl ID | - |
| PharmGKB ID | PA37234 |
Protein Information
| Protein ID | NP_001259004.1 |
|---|---|
| Protein Name | ubiquitin specific peptidase 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 798 |
| Uniprot ID | Q7L8A9 |
| Ensembl Protein ID | ENSP00000167106 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 211 |
| S | Phosphorylation | 576 |
| T | Phosphorylation | 100 |
| T | Phosphorylation | 205 |
| S | Phosphorylation | 218 |
| S | Phosphorylation | 220 |
| T | Phosphorylation | 216 |
| S | Phosphorylation | 226 |
| S | Phosphorylation | 355 |
| S | Phosphorylation | 365 |
| Y | Phosphorylation | 364 |
| S | Phosphorylation | 370 |
| S | Phosphorylation | 563 |
| S | Phosphorylation | 713 |
| S | Phosphorylation | 547 |
| T | Phosphorylation | 208 |
| Y | Phosphorylation | 77 |
| S | Phosphorylation | 5 |
| Y | Phosphorylation | 8 |
| S | Phosphorylation | 14 |
| T | Phosphorylation | 24 |
| S | Phosphorylation | 549 |
| S | Phosphorylation | 718 |
| T | Phosphorylation | 74 |
| S | Phosphorylation | 354 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6337 | SCNN1A | 2575 | NP_001029.1 | in vivo | 18632802 |
| 6340 | SCNN1G | 2862 | NP_001030.2 | in vivo | 18632802 |
| 8724 | SNX3 | 9333 | NP_003786.1 | in vitro;in vivo;yeast 2-hybrid | 18632802 |
| 10146 | G3BP1 | 6569 | NP_005745.1 | in vitro;in vivo | 11439350 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02257 | 520-793 | Peptidase_C19 |
| cl02553 | 520-793 | Peptidase_C19 superfamily |
| cd02661 | 414-792 | Peptidase_C19E |
| cd02660 | 415-792 | Peptidase_C19D |
| cd02674 | 602-793 | Peptidase_C19R |
| cd02663 | 618-792 | Peptidase_C19G |
| cd02659 | 602-796 | peptidase_C19C |
| cd02657 | 416-793 | Peptidase_C19A |
| cd02671 | 416-793 | Peptidase_C19O |
| cd02668 | 621-793 | Peptidase_C19L |
| cd02667 | 596-793 | Peptidase_C19K |
| cd02664 | 416-752 | Peptidase_C19H |
| cd02658 | 416-793 | Peptidase_C19B |
| cd02662 | 416-792 | Peptidase_C19F |
| cd02669 | 416-774 | Peptidase_C19M |
| cd02665 | 579-792 | Peptidase_C19I |
| cd02673 | 631-792 | Peptidase_C19Q |
| cd02670 | 625-793 | Peptidase_C19N |
| cd02666 | 644-792 | Peptidase_C19J |
| pfam00443 | 414-792 | UCH |
| COG5533 | 346-795 | COG5533 |
| COG5077 | 596-770 | COG5077 |
| pfam13423 | 416-770 | UCH_1 |
| COG5560 | 670-794 | UBP12 |
| COG5207 | 416-537 | UBP14 |
| COG5207 | 732-794 | UBP14 |
Ontology Information
| HPRD ID | 9732 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.