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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23371285 | 2013 | Cell line : HCT 116 , LoVo Source : - Sample Type : CRC Tumor and normal tissue No. of Sample : 18 normal tissues and 91 CRC tumor Stage : TNM Stage I-IV | Immunohistochemistry. | Up-regulation | - | MTA1 is highly expressed in higher grade tumors and is important in the orchestration of various phenotypic changes in CRC, most likely by inducing EMT.IHC indicated low or no nuclear MTA1 expression in the normal tissues and significantly higher expression in Grade II, Grade III and liver metastasis tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| Chromosome | 14 |
| Location | 14q32.33 |
| Start | 105886186 |
| End | 105937066 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 50881 |
| OMIM ID | 603526 |
| HGNC ID | HGNC:7410 |
| Unigene ID | Hs.525629 |
| Ensembl ID | ENSG00000182979 |
| PharmGKB ID | PA31218 |
Protein Information
| Protein ID | NP_001190187.1 |
|---|---|
| Protein Name | metastasis associated 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 715 |
| Uniprot ID | Q9Y2L1 |
| Ensembl Protein ID | ENSP00000366997 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 576 |
| T | Phosphorylation | 578;- |
| S | Phosphorylation | 446;- |
| T | Phosphorylation | 467;- |
| S | Phosphorylation | 386 |
| S | Phosphorylation | 449 |
| S | Phosphorylation | 522 |
| T | Phosphorylation | 564 |
| S | Phosphorylation | 520 |
| S | Phosphorylation | 561 |
| S | Phosphorylation | 562 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2099 | ESR1 | 589 | NP_000116.2 | in vivo | 12167865 |
| 2647 | BLOC1S1 | 3263 | NP_001478.1 | in vitro;in vivo;yeast 2-hybrid | 12639951 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro | 11483358 |
| 3065 | HDAC1 | 3143 | NP_004955.2 | in vitro;in vivo | 111 466 231 084 094 000 000 000 |
| 4331 | MNAT1 | 4042 | NP_002422.1 | in vitro;in vivo;yeast 2-hybrid | 12527756 |
| 5928 | RBBP4 | 4232 | NP_005601.1 | in vitro | 12920132 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro | 12920132 |
| 8655 | DYNLL1 | 3334 | NP_003737.1 | in vitro | 14760703 |
| 51100 | SH3GLB1 | 15333 | NP_057093.1 | in vitro;in vivo;yeast 2-hybrid | 15978591 |
| 51497 | TH1L | 16096 | NP_945327.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04709 | 3-188 | BAH_MTA |
| cl02608 | 3-188 | BAH superfamily |
| cd11661 | 287-332 | SANT_MTA3_like |
| cl21498 | 287-332 | SANT superfamily |
| cd00202 | 392-448 | ZnF_GATA |
| cl00158 | 392-448 | ZnF_GATA superfamily |
| cd04370 | 3-160 | BAH |
| pfam01426 | 4-164 | BAH |
| smart00439 | 5-164 | BAH |
| pfam01448 | 167-221 | ELM2 |
| cl03218 | 167-221 | ELM2 superfamily |
| pfam00320 | 393-430 | GATA |
| cd00167 | 287-331 | SANT |
| pfam00249 | 287-331 | Myb_DNA-binding |
| cd04717 | 5-128 | BAH_polybromo |
| smart00401 | 388-441 | ZnF_GATA |
| smart00717 | 286-333 | SANT |
Ontology Information
| HPRD ID | 4379 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Protein binding (GO:0005515) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.