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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20957031 | 2010 | Cell line : - Source : Chonbuk National University Hospital (Jeonju, Jeonbuk, South Korea). Sample Type : Tumor and normal tissue No. of Sample : - Stage : TNM Stage I-IV | Flow cytometry,cDNA microarray,real time RT-PCR | Down-regulation | - | - |
| 17289878 | 2007 | Cell line : HT29,GC3/c1. Source : - Sample Type : - No. of Sample : - Stage : - | Northern blotting, Immunoreactivity,transfection,chromatin immunoprecipitation | Up-regulation | - | Cyclin B2 seems to be a molecular marker of a colorectal adenocarcinoma and that its up-regulation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008] |
| Chromosome | 15 |
| Location | 15q21.3 |
| Start | 59397284 |
| End | 59417244 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 19961 |
| OMIM ID | 602755 |
| HGNC ID | HGNC:1580 |
| Unigene ID | Hs.194698 |
| Ensembl ID | ENSG00000157456 |
| PharmGKB ID | PA26148 |
Protein Information
| Protein ID | NP_004692.1 |
|---|---|
| Protein Name | cyclin B2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 398 |
| Uniprot ID | Q9UPV9 |
| Ensembl Protein ID | ENSP00000328998 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 92 |
| S | Phosphorylation | 99 |
| T | Phosphorylation | 94 |
| S | Phosphorylation | 398 |
| S | Phosphorylation | 392 |
| S | Phosphorylation | 204 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 983 | CDK1 | 302 | NP_001777.1 | in vitro;in vivo | 9926943 |
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro | 15232106 |
| 1026 | CDKN1A | 298 | NP_510867.1 | in vitro | 15232106 |
| 4171 | MCM2 | 303 | NP_004517.2 | in vitro | 15232106 |
| 7048 | TGFBR2 | 1823 | NP_001020018.1 | in vitro;yeast 2-hybrid | 9926943 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| FoxO signaling pathway | hsa04068 |
| HTLV-I infection | hsa05166 |
| Oocyte meiosis | hsa04114 |
| p53 signaling pathway | hsa04115 |
| Progesterone-mediated oocyte maturation | hsa04914 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 165-254 | CYCLIN |
| cl00050 | 165-254 | CYCLIN superfamily |
| cd00043 | 262-347 | CYCLIN |
| cl00050 | 262-347 | CYCLIN superfamily |
| pfam00134 | 137-262 | Cyclin_N |
| pfam02984 | 264-382 | Cyclin_C |
| smart00385 | 171-255 | CYCLIN |
| smart00385 | 268-349 | CYCLIN |
| pfam04729 | 191-249 | ASF1_hist_chap |
| cl22451 | 191-249 | ASF1_hist_chap superfamily |
| COG5024 | 118-379 | COG5024 |
| COG5333 | 172-339 | CCL1 |
Ontology Information
| HPRD ID | 5802 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | ATP binding (GO:0005524) |
| Biological Process | Spindle assembly (GO:0007051) |
Drug Information
No matching records could be found.