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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20957031 | 2010 | Cell line : HT29 cells Source : - Sample Type : No. of Sample : - Stage : - | Analyses using GenomeStudio (statistics), Matlab (heat map), Ingenuity (canonical pathway analysis), real time RT-PCR | Down-regulation | 3.22 -3.24 | Genes that determine further cell cycle progression at G1/S including E2F2, CYCLIN E2 (CCNE2), CDC25A and CDK2, and genes that regulate passage of cells through G2/M (CYCLIN A2 [CCNA2], CDC25C, CYCLIN B2 [CCNB2], CDC20 and CDC2 [CDK1], were down-regulated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008 |
| Chromosome | 8 |
| Location | 8q22.1 |
| Start | 95892452 |
| End | 95909672 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 17221 |
| OMIM ID | 603775 |
| HGNC ID | HGNC:1590 |
| Unigene ID | Hs.521693 |
| Ensembl ID | ENSG00000175305 |
| PharmGKB ID | PA26155 |
Protein Information
| Protein ID | NP_477097.1 |
|---|---|
| Protein Name | cyclin E2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 404 |
| Uniprot ID | Q15691 |
| Ensembl Protein ID | ENSP00000364721 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 392 |
| T | Phosphorylation | 19 |
| T | Phosphorylation | 19 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 21 |
| S | Phosphorylation | 383 |
| S | Phosphorylation | 338 |
| S | Phosphorylation | 63 |
| S | Phosphorylation | 63 |
| T | Phosphorylation | 347 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 351 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1017 | CDK2 | 310 | NP_001789.2 | in vitro;in vivo | 985 858 515 232 106 |
| 1018 | CDK3 | 446 | NP_001249.1 | yeast 2-hybrid | 9840943 |
| 1026 | CDKN1A | 298 | NP_510867.1 | yeast 2-hybrid | 152 321 069 840 943 |
| 1027 | CDKN1B | 2867 | NP_004055.1 | in vitro;in vivo;yeast 2-hybrid | 9 858 585 984 094 310 000 000 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| Hepatitis B | hsa05161 |
| Measles | hsa05162 |
| MicroRNAs in cancer | hsa05206 |
| Oocyte meiosis | hsa04114 |
| p53 signaling pathway | hsa04115 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Prostate cancer | hsa05215 |
| Small cell lung cancer | hsa05222 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 141-231 | CYCLIN |
| cl00050 | 141-231 | CYCLIN superfamily |
| pfam00134 | 112-239 | Cyclin_N |
| smart00385 | 147-232 | CYCLIN |
| pfam02984 | 241-361 | Cyclin_C |
| cl00050 | 241-361 | CYCLIN superfamily |
| COG5024 | 110-238 | COG5024 |
Ontology Information
| HPRD ID | 10304 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.