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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19197948 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 43 colorectal carcinomas with MSI-H and 15 colorectal carcinomas with MSI-L Stage : - | Frameshift mutations | Unknown | - | ATG2B, ATG5, ATG9B and�ATG12�mutations in 10, 2, 13 and 0 cancers, respectively.� |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008] |
| Chromosome | 5 |
| Location | 5q21-q22 |
| Start | 115163893 |
| End | 115177548 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13656 |
| OMIM ID | 609608 |
| HGNC ID | HGNC:588 |
| Unigene ID | Hs.264482 |
| Ensembl ID | ENSG00000145782 |
| PharmGKB ID | PA24879 |
Protein Information
| Protein ID | NP_001264712.1 |
|---|---|
| Protein Name | autophagy related 12 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 140 |
| Uniprot ID | Q8IXJ6 |
| Ensembl Protein ID | ENSP00000249396 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5359 | PLSCR1 | 8855 | NP_066928.1 | yeast 2-hybrid | 16189514 |
| 83755 | KRTAP4-12 | 13941 | NP_114060.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| Regulation of autophagy | hsa04140 |
| RIG-I-like receptor signaling pathway | hsa04622 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01612 | 54-140 | APG12_C |
| cl00155 | 54-140 | UBQ superfamily |
| pfam04110 | 54-140 | APG12 |
| pfam02991 | 57-140 | Atg8 |
| cd01611 | 57-121 | GABARAP |
Ontology Information
| HPRD ID | 11056 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.