Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EDG4 | 9170 | Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 | 19 | EDG4; LPA2; EDG-4; LPA-2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15220934 | 2004 | Cell line : - Source : Department of Surgical Oncology of the University of Tokyo. Sample Type : CRC tumor No. of Sample : 26 CRC and 16 normal tissue Stage : - | RT-PCR, Immunohistochemistry, Western blotting | Up-regulation | - | In colorectal cancers expressed LPA2 mRNA at a significantly higher level as compared with normal tissues. LPA receptor expression might be an important event in the development of colorectal cancer. |
| 15728708 | 2005 | Cell line : Caco 2, SW 480 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Cloning of LPA2, Hybridization of the cancer profiling array | Up-regulation | - | LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2. Found that expression of LPA2 was elevated, whereas expression of LPA1 downregulated in several types of cancers, including ovarian and colon cancer |
| 20890765 | 2010 | Cell line : DLD 1, SW 480, HCT 116, CaCo 2, SW 48, and LoVo Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, Bisulfite sequencing analyses,PCR-SSCP | Up-regulation | - | LPA1, LPA2, and LPA4 genes were expressed in DLD1, SW480, HCT116, CaCo-2, SW48, and LoVo cells. |
| 21134377 | 2011 | Cell line : HCT 116, SW 480 Source : - Sample Type : - No. of Sample : - Stage : - | Cell invasion and migration, Inositol phosphates (IP) generation, Cell Surface Expression Assay | Up-regulation | - | LPA(2) is dynamically regulated by 2 distinct PDZ proteins via modulation of G-protein coupling and receptor signaling. MAGI-3 is a negative regulator of LPA(2) signaling. (LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA(2)) is overexpressed in colon tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid |
| Description | This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19p12 |
| Start | 19623655 |
| End | 19628930 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5276 |
| OMIM ID | 605110 |
| HGNC ID | HGNC:3168 |
| Unigene ID | Hs.122575 |
| Ensembl ID | ENSG00000064547 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011528420.1 |
|---|---|
| Exon | join(1..503,718..839,1647..2388,4362..5276) | mRNA Sequence | Download Select all |
| Length | 2282 |
CDS Information
| Location | join(1647..2388,4362..4675) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12407.1 |
Protein Information
| Protein ID | NP_004711.2 |
|---|---|
| Protein Name | Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 |
| Molecular Wt. (Da) | 38953 |
| Protein Sequence | Download Select all |
| Length | 351 |
| Uniprot ID | P63241 |
| Ensembl Protein ID | ENSP00000336702 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7205 | TRIP6 | 4242 | NP_003293.2 | in vitro;in vivo;yeast 2-hybrid | 14688263 |
| 9351 | SLC9A3R2 | 5946 | NP_001123484.1 | in vitro | 16203867 |
| 9826 | ARHGEF11 | 9302 | NP_937879.1 | in vitro;in vivo | 15755723 |
| 23365 | ARHGEF12 | 9207 | NP_056128.1 | in vitro;in vivo | 15755723 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 11892 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.