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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CABLES1 | 91768 | Cdk5 and Abl enzyme substrate 1 | 18 | HsT2563, FLJ35924 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23792637 | 2013 | Cell line : SW480 Source : Jackson Laboratory Sample Type : Mouse model No. of Sample : - Stage : - | Genotyping,Immunohistochemistry, Transfections and luciferase assay | Down-regulation | - | Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model and likely has a similar role in human colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| Chromosome | 18 |
| Location | 18q11.2 |
| Start | 20714528 |
| End | 20840434 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 125907 |
| OMIM ID | 609194 |
| HGNC ID | HGNC:25097 |
| Unigene ID | Hs.11108 |
| Ensembl ID | - |
| PharmGKB ID | PA134880184 |
Protein Information
| Protein ID | NP_001094089.1 |
|---|---|
| Protein Name | Cdk5 and Abl enzyme substrate 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 633 |
| Uniprot ID | Q8WVJ9 |
| Ensembl Protein ID | ENSP00000405176 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 48 |
| S | Phosphorylation | 48 |
| T | Phosphorylation | 150 |
| S | Phosphorylation | 108 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 169 |
| T | Phosphorylation | 44 |
| S | Phosphorylation | 46 |
| S | Phosphorylation | 113 |
| S | Phosphorylation | 22 |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 153 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 25 | ABL1 | 1809 | NP_009297.2 | in vitro;in vivo | 11955625 |
| 1020 | CDK5 | 449 | NP_004926.1 | in vivo;yeast 2-hybrid | 108 961 591 173 300 000 000 000 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 1 463 716 811 706 030 |
| 7161 | TP73 | 3587 | NP_005418.1 | in vitro;in vivo | 11706030 |
| 8900 | CCNA1 | 4946 | NP_003905.1 | in vivo | 11733001 |
| 23424 | TDRD7 | 11626 | NP_055105.2 | in vitro;in vivo;yeast 2-hybrid | 11527406 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00043 | 516-601 | CYCLIN |
| cl00050 | 516-601 | CYCLIN superfamily |
| pfam00134 | 533-613 | Cyclin_N |
| COG5333 | 507-618 | CCL1 |
Ontology Information
| HPRD ID | 15812 |
|---|---|
| Molecular Class | Adapter molecule |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.