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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21508378 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 56 Stage : - | methylation-specific PCR | Methylation | - | OSMR may act as a tumour suppressor in colorectal carcinoma and OSMR methylation may play an important role in non-invasive colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibronectin type III domain containing |
| Description | This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] |
| Chromosome | 5 |
| Location | 5p13.2 |
| Start | 38845960 |
| End | 38935743 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 89784 |
| OMIM ID | 601743 |
| HGNC ID | HGNC:8507 |
| Unigene ID | Hs.120658 |
| Ensembl ID | ENSG00000145623 |
| PharmGKB ID | PA32837 |
Protein Information
| Protein ID | NP_001161827.1 |
|---|---|
| Protein Name | oncostatin M receptor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 979 |
| Uniprot ID | Q8IZQ1 |
| Ensembl Protein ID | ENSP00000295888 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 837;- |
| S | Phosphorylation | 826 |
| T | Phosphorylation | 828 |
| T | Phosphorylation | 830 |
| S | Phosphorylation | 889 |
| Y | Phosphorylation | 379 |
| S | Phosphorylation | 382 |
| S | Phosphorylation | 605 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3572 | IL6ST | 2824 | NP_002175.2 | in vitro | 9188471 |
| 3716 | JAK1 | 992 | NP_002218.2 | in vivo | 10586060 |
| 3717 | JAK2 | 993 | NP_004963.1 | in vivo | 10586060 |
| 5008 | OSM | 1300 | NP_065391.1 | in vitro;in vivo | 109 979 058 999 038 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Jak-STAT signaling pathway | hsa04630 |
| PI3K-Akt signaling pathway | hsa04151 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00063 | 625-733 | FN3 |
| cl21522 | 625-733 | FN3 superfamily |
| cd00063 | 335-419 | FN3 |
| cl21522 | 335-419 | FN3 superfamily |
| cd00063 | 445-521 | FN3 |
| cl21522 | 445-521 | FN3 superfamily |
| cd00063 | 539-602 | FN3 |
| cl21522 | 539-602 | FN3 superfamily |
| pfam00041 | 539-607 | fn3 |
| smart00060 | 625-723 | FN3 |
| pfam00041 | 624-724 | fn3 |
| pfam09067 | 233-288 | EpoR_lig-bind |
| cl21522 | 233-288 | FN3 superfamily |
| smart00060 | 539-602 | FN3 |
| smart00060 | 335-406 | FN3 |
| pfam00041 | 434-518 | fn3 |
| smart00060 | 436-515 | FN3 |
Ontology Information
| HPRD ID | 11118 |
|---|---|
| Molecular Class | Cytokine receptor |
| Molecular Function | Protein serine/threonine phosphatase activity (GO:0004722) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.