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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| REPS2 | 9185 | RALBP1 associated Eps domain containing 2 | X | POB1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25788273 | 2015 | Cell line : SW480 ADH, DLD 1, RKO Source : Fundacin Jimnez Daz Biobank. Sample Type : Formalin-fixed paraffin-embedded tissue No. of Sample : Colon control 16 and small intestine 16, colorectal adenoma 76 and mCRC 699 Stage : - | Immunofluorescence, immunohistochemical and confocal microscopy analyses of human tissues and cultured cells,Western blotting,ChIP-sequencing assay. | Up-regulation | - | Overexpression of ALDH1A1 and REPS2 associates with nuclear DKK-1 expression in tumors and correlates with decreased OS (P = 0.001 and 0.014) and PFS. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | X |
| Location | Xp22.2 |
| Start | 16964814 |
| End | 17171403 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 206590 |
| OMIM ID | 300317 |
| HGNC ID | HGNC:9963 |
| Unigene ID | Hs.186810 |
| Ensembl ID | ENSG00000169891 |
| PharmGKB ID | PA34330 |
Protein Information
| Protein ID | NP_001074444.1 |
|---|---|
| Protein Name | RALBP1 associated Eps domain containing 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 660 |
| Uniprot ID | Q8TEY7 |
| Ensembl Protein ID | ENSP00000350009 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 121 |
| S | Phosphorylation | 121 |
| S | Phosphorylation | 121 |
| Y | Phosphorylation | 558 |
| Y | Phosphorylation | 558 |
| Y | Phosphorylation | 557 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 254 |
| S | Phosphorylation | 253 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo | 9422736 |
| 5899 | RALB | 1550 | NP_002872.1 | in vitro | 9422736 |
| 5970 | RELA | 1241 | NP_068810.3 | yeast 2-hybrid | 15184881 |
| 55755 | CDK5RAP2 | 9740 | NP_060719.4 | yeast 2-hybrid | 15184881 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00052 | 286-352 | EH |
| cl08302 | 286-352 | EFh superfamily |
| pfam12763 | 274-367 | EF-hand_4 |
| cl22916 | 274-367 | EF-hand_4 superfamily |
| cd00052 | 75-121 | EH |
| cl08302 | 75-121 | EFh superfamily |
| smart00027 | 275-370 | EH |
| smart00027 | 75-125 | EH |
| PTZ00108 | 393-639 | PTZ00108 |
Ontology Information
| HPRD ID | 5624 |
|---|---|
| Molecular Class | Calcium binding protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.