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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
DDX21 9188 DEAD (Asp-Glu-Ala-Asp) box helicase 21  10RH-II/GU, GURDB 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21304002   2011Cell line : -

Source : Publicly available data from GenBank and Oncomine

Sample Type : -

No. of Sample : -

Stage : -

 RT-PCR,Meta-analysisUp-regulation- 9 (ECT2, ETV4, DDX21, RAN, S100A11, RPS4X, HSPD1, CKS2, and C9orf140) of the 34 candidate genes are expressed at significantly elevated levels in CRC tissues compared to normal tissues.


Gene Details



NC_000010.10 (70715879..70744825)

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Gene Type protein coding
Gene Family DEAD-boxes
Description DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]  
Chromosome 10
Location 10q21
Start 70715879  
End 70744825  
Strand +  
Gene Sequence

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Length 28947  
OMIM ID 606357   
HGNC ID HGNC:2744   
Unigene ID Hs.223141   
Ensembl ID ENSG00000165732   
PharmGKB ID PA27210   

mRNA Information


mRNA ID ?NM_001256910.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS31211.1



Protein Information


      
Protein IDNP_001243839.1
Protein NameDEAD (Asp-Glu-Ala-Asp) box helicase 21
Molecular Wt. (Da)0
Protein Sequence

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Length 783  
Uniprot IDQ6ZVD8
Ensembl Protein ID ENSP00000377159  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation171
SPhosphorylation71
SPhosphorylation121
SPhosphorylation89
SPhosphorylation89;-
SPhosphorylation71;-
SPhosphorylation13;-
SPhosphorylation121;-
SPhosphorylation164
SPhosphorylation168
SPhosphorylation173
TPhosphorylation315
SPhosphorylation567
KAcetylation779
SPhosphorylation358
YPhosphorylation361
TPhosphorylation296
SPhosphorylation466
SPhosphorylation513
TPhosphorylation569

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3725JUN1302NP_002219.1in vitro;in vivo11823437   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00268188-395  DEADc
cl21455188-395  P-loop_NTPase superfamily
cd12936617-709  GUCT_RHII_Gualpha_beta
cl06960617-709  GUCT superfamily
cd00079411-538  HELICc
cl21455411-538  P-loop_NTPase superfamily
pfam00270211-385  DEAD
cd00046224-377  DEXDc
pfam08152620-709  GUCT
pfam00271466-532  Helicase_C
smart00490466-532  HELICc
cd12937627-712  GUCT_RH7_like
cd12929635-708  GUCT
cd09639225-533  Cas3_I
PTZ00146718-771  PTZ00146
cl17173718-771  AdoMet_MTases superfamily
pfam14617306-339  CMS1
PTZ00146716-766  PTZ00146
PTZ00146722-776  PTZ00146
pfam15320731-772  RAM
cl21165731-772  RAM superfamily
PTZ00146716-767  PTZ00146
pfam04851224-280  ResIII
PTZ00424168-554  PTZ00424
COG0513178-587  SrmB
PRK11776187-569  PRK11776
PRK11634185-568  PRK11634
PRK01297177-561  PRK01297
PRK04837182-549  PRK04837
PTZ00110180-541  PTZ00110
PRK11192188-538  PRK11192
PRK04537188-540  PRK04537
PRK10590211-544  PRK10590
PLN00206211-562  PLN00206
smart00487201-391  DEXDc
COG1205182-535  YprA
COG1204178-553  BRR2
COG1201185-541  Lhr
COG1061207-527  SSL2
COG1202155-599  COG1202
PRK13766473-635  PRK13766
COG0514213-541  RecQ
COG1111440-547  MPH1
TIGR01389437-541  recQ
TIGR04121202-539  DEXH_lig_assoc
TIGR00614437-541  recQ_fam
TIGR01587225-533  cas3_core
PRK09751464-529  PRK09751
TIGR00643262-538  recG
TIGR00631431-543  uvrb
COG0556440-533  UvrB
PRK00254192-527  PRK00254
PLN03137442-543  PLN03137
PRK11057430-541  PRK11057
TIGR01054157-506  rgy
COG1643467-609  HrpA
PRK05298447-509  PRK05298
COG1197468-545  Mfd
TIGR01970430-549  DEAH_box_HrpB
pfam03276700-776  Gag_spuma
TIGR00580467-545  mfd
COG1200467-545  RecG
TIGR03817469-533  DECH_helic
PRK13767500-529  PRK13767
COG4096226-282  HsdR


Ontology Information


   
HPRD ID10290
Molecular ClassATPase
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO