Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| LGI1 | 9211 | leucine-rich, glioma inactivated 1 | 10 | IB1099, ETL1, EPITEMPIN |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19557575 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 23 Stage : - | GRNInfer tool and DAVID based on linear programming and a decomposition procedure with integrated Kappa statistics and fuzzy heuristic clustering | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| Chromosome | 10 |
| Location | 10q24 |
| Start | 95517566 |
| End | 95557916 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40351 |
| OMIM ID | 604619 |
| HGNC ID | HGNC:6572 |
| Unigene ID | Hs.533670 |
| Ensembl ID | ENSG00000108231 |
| PharmGKB ID | PA30349 |
Protein Information
| Protein ID | NP_001295204.1 |
|---|---|
| Protein Name | leucine-rich, glioma inactivated 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 557 |
| Uniprot ID | O60281 |
| Ensembl Protein ID | ENSP00000358590 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03736 | 463-506 | EPTP |
| cl04240 | 463-506 | EPTP superfamily |
| pfam03736 | 510-549 | EPTP |
| cl04240 | 510-549 | EPTP superfamily |
| pfam03736 | 270-313 | EPTP |
| cl04240 | 270-313 | EPTP superfamily |
| pfam03736 | 418-462 | EPTP |
| cl04240 | 418-462 | EPTP superfamily |
| pfam03736 | 316-364 | EPTP |
| cl04240 | 316-364 | EPTP superfamily |
| pfam03736 | 224-267 | EPTP |
| cl04240 | 224-267 | EPTP superfamily |
| smart00082 | 173-221 | LRRCT |
| cl15307 | 173-221 | LRRCT superfamily |
| pfam12799 | 115-155 | LRR_4 |
| cl19302 | 115-155 | LRR_4 superfamily |
| pfam03736 | 365-414 | EPTP |
| cl04240 | 365-414 | EPTP superfamily |
| smart00370 | 138-161 | LRR |
| cl19480 | 138-161 | LRR superfamily |
| smart00369 | 138-161 | LRR_TYP |
| cl19479 | 138-161 | LRR_TYP superfamily |
| pfam13855 | 91-151 | LRR_8 |
| pfam13855 | 115-175 | LRR_8 |
| TIGR00864 | 146-221 | PCC |
| pfam13855 | 71-127 | LRR_8 |
| PRK15370 | 57-177 | PRK15370 |
| COG4886 | 59-176 | LRR |
| pfam13306 | 77-170 | LRR_5 |
| COG4886 | 70-173 | LRR |
| pfam13306 | 80-173 | LRR_5 |
Ontology Information
| HPRD ID | 12016 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.