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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24946951 | 2014 | Cell line : - Source : - Sample Type : CRC tissue and blood sample No. of Sample : 85 Stage : TNM Stage II,III | Immunohistochemistry | Up-regulation | - | High MTDH expression is a biomarker of relapse in CRC, including lung-specific relapse. Determination of MTDH expression in primary CRC may be useful in the earlier detection of lung metastases in patients with high expression and increased risk |
| 25009642 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | AEG-1/MTDH may be used as a biomarker to identify subgroups of patients who require more intensive treatments and who are likely to benefit from AEG-1/MTDH-targeted therapies. The therapeutic targeting of AEG-1/MTDH may simultaneously block metastasis, suppress tumor growth and enhance the efficacy of chemotherapeutic treatments. Studies have established that AEG-1/MTDH is crucial in tumor progression, including transformation, the evasion of apoptosis, invasion, angiogenesis and metastasis. |
| 22351252 | 2012 | Cell line : - Source : - Sample Type : CRC tissue and blood sample No. of Sample : 520 cases. Stage : - | real time RT-PCR and immunohistochemistry | Up-regulation | - | AEG-1 protein may be a potential new early liver metastasis biomarker of colorectal cancer. Both mRNA and protein level AEG-1 were over-expressed in the cases with liver metastasis compared with those without liver metastasis (P=0.01). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | - |
| Chromosome | 8 |
| Location | 8q22.1 |
| Start | 97644147 |
| End | 97730260 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 86114 |
| OMIM ID | 610323 |
| HGNC ID | HGNC:29608 |
| Unigene ID | Hs.377155 |
| Ensembl ID | ENSG00000147649 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011517367.1 |
|---|---|
| Exon | join(1..741,16926..17027,42522..42606,43283..43459, 44892..44957,46806..47042,52058..52147,55608..55706, 62480..62604,69516..69623,74903..75043,78733..78889, 80454..82168) | mRNA Sequence | Download Select all |
| Length | 7667 |
CDS Information
| Location | join(361..741,16926..17027,42522..42606,43283..43459, 44892..44957,46806..47042,52058..52147,55608..55706, 62480..62604,69516..69623,74903..75043,78733..78889, 80454..80524) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_848927.2 |
|---|---|
| Protein Name | metadherin |
| Molecular Wt. (Da) | 63706 |
| Protein Sequence | Download Select all |
| Length | 582 |
| Uniprot ID | P20700 |
| Ensembl Protein ID | ENSP00000261366 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 426;- |
| S | Phosphorylation | 111;- |
| S | Phosphorylation | 478;- |
| S | Phosphorylation | 298;- |
| S | Phosphorylation | 415;- |
| S | Phosphorylation | 308;- |
| S | Phosphorylation | 311;- |
| T | Phosphorylation | 143 |
| S | Phosphorylation | 146 |
| S | Phosphorylation | 457 |
| T | Phosphorylation | 458 |
| S | Phosphorylation | 568 |
| T | Phosphorylation | 439 |
| S | Phosphorylation | 295 |
| S | Phosphorylation | 494 |
| S | Phosphorylation | 306 |
| S | Phosphorylation | 294 |
| S | Phosphorylation | 84 |
| S | Phosphorylation | 216 |
| S | Phosphorylation | 219 |
| T | Phosphorylation | 492 |
| T | Phosphorylation | 495 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
No matching records could be found.
Ontology Information
| HPRD ID | 1738 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.