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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTTG1 | 9232 | pituitary tumor-transforming 1 | 5 | PTTG, HPTTG, EAP1, securin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26264222 | 2015 | Cell line : HCT116, SW620 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Illumina microarray,Luciferase reporter array, EMSA and Chromatin Immunoprecipitation ,Boyden chamber assay, real-time PCR,Western blotting | Unknown | - | PTTG1 is a FoxM1 targeted gene. FoxM1 binds to PTTG1 promoter to enhance PTTG1 transcription, and FoxM1-PTTG1 pathway promotes colorectal cancer migration and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] |
| Chromosome | 5 |
| Location | 5q35.1 |
| Start | 159848865 |
| End | 159855747 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6883 |
| OMIM ID | 604147 |
| HGNC ID | HGNC:9690 |
| Unigene ID | Hs.350966 |
| Ensembl ID | ENSG00000164611 |
| PharmGKB ID | PA34033 |
Protein Information
| Protein ID | NP_001269311.1 |
|---|---|
| Protein Name | pituitary tumor-transforming 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 202 |
| Uniprot ID | Q9H3R0 |
| Ensembl Protein ID | ENSP00000370707 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Ubiquitination | 9 |
| S | Phosphorylation | 165 |
| S | Phosphorylation | 165 |
| S | Phosphorylation | 181 |
| S | Phosphorylation | 184 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 754 | PTTG1IP | 4807 | NP_004330.1 | in vitro;in vivo;yeast 2-hybrid | 10781616 |
| 991 | CDC20 | 4686 | NP_001246.2 | in vitro;in vivo | 11553328 |
| 2547 | XRCC6 | 1071 | NP_001460.1 | in vitro;in vivo | 11238996 |
| 3301 | DNAJA1 | 4159 | NP_001530.1 | in vitro;in vivo;yeast 2-hybrid | 9915854 |
| 6204 | RPS10 | 4697 | NP_001005.1 | in vitro;in vivo;yeast 2-hybrid | 9915854 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 12355087 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| HTLV-I infection | hsa05166 |
| Oocyte meiosis | hsa04114 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 18983 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.