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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22037460 | 2011 | Cell line : - Source : Taipei Veterans General Hospital. Sample Type : CRC Tumor No. of Sample : - Stage : - | real time RT-PCR, immunoblotting and immunofluorescence,Microarray | Up-regulation | - | IL-8 and IL-32 play a role in regulating the CSC-like properties that promote tumorigenesis of CRCs in both autocrine and paracrine manners.CSC markers, stemness genes, drug-resistant genes, as well as interleukin (IL)-8 and IL-32 were upregulated. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Interleukins and interleukin receptors |
| Description | This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16p13.3 |
| Start | 3115313 |
| End | 3119668 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4356 |
| OMIM ID | 606001 |
| HGNC ID | HGNC:16830 |
| Unigene ID | Hs.943 |
| Ensembl ID | ENSG00000008517 |
| PharmGKB ID | PA128395754 |
Protein Information
| Protein ID | NP_001012649.1 |
|---|---|
| Protein Name | interleukin 32 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 234 |
| Uniprot ID | Q5T200 |
| Ensembl Protein ID | ENSP00000242848 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 48 |
| T | Proteolytic Cleavage | 57 |
| T | Proteolytic Cleavage | 37 |
| T | Proteolytic Cleavage | 37 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 16499 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Peptidase activity (GO:0008233) |
| Biological Process | Proteolysis and peptidolysis (GO:0006508) |
Drug Information
No matching records could be found.