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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AIMP1 | 9255 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 | 4 | EMAPII, EMAP-2, p43 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21789020 | 2011 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 103 Stage : The TNM stages I-IV | Tissue microarray, Immunohistochemistry, | Down-regulation | - | The decreased expression of AIMP1, AIMP2 and AIMP3 in the GC and CRC tissues compared to the corresponding normal tissues suggested that downregulation of these proteins may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008] |
| Chromosome | 4 |
| Location | 4q24 |
| Start | 107236767 |
| End | 107270382 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33616 |
| OMIM ID | 603605 |
| HGNC ID | HGNC:10648 |
| Unigene ID | Hs.591680 |
| Ensembl ID | ENSG00000164022 |
| PharmGKB ID | PA35578 |
Protein Information
| Protein ID | NP_001135887.1 |
|---|---|
| Protein Name | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 312 |
| Uniprot ID | O15054 |
| Ensembl Protein ID | ENSP00000254846 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 33 |
| T | Phosphorylation | 84 |
| T | Phosphorylation | 109 |
| S | Phosphorylation | 99 |
| S | Phosphorylation | 107 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 498 | ATP5A1 | 1258 | NP_004037.1 | in vitro;in vivo | 11741979 |
| 1432 | MAPK14 | 2619 | NP_001306.1 | yeast 2-hybrid | 9878398 |
| 5917 | RARS | 142 | NP_002878.2 | in vitro | 10358004 |
| 7965 | AIMP2 | 2915 | NP_006294.2 | in vitro | 12 729 910 128 197 800 000 000 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02799 | 150-252 | tRNA_bind_EMAP-II_like |
| cl00320 | 150-252 | tRNA_bindingDomain superfamily |
| cd02153 | 157-251 | tRNA_bindingDomain |
| pfam01588 | 157-250 | tRNA_bind |
| cd02800 | 151-251 | tRNA_bind_EcMetRS_like |
| cd02798 | 151-251 | tRNA_bind_CsaA |
| COG0073 | 148-251 | EMAP |
| PRK10089 | 151-251 | PRK10089 |
| TIGR02222 | 151-251 | chap_CsaA |
| cd02796 | 157-230 | tRNA_bind_bactPheRS |
| pfam04880 | 32-104 | NUDE_C |
| cl23541 | 32-104 | NUDE_C superfamily |
| PRK08476 | Jan-66 | PRK08476 |
| cl21478 | Jan-66 | Mt_ATP-synt_B superfamily |
| pfam06156 | 22-78 | DUF972 |
| cl22921 | 22-78 | DUF972 superfamily |
| PRK13169 | 20-65 | PRK13169 |
| cl01853 | 20-65 | YabA superfamily |
| pfam05266 | Jan-65 | DUF724 |
| cl21643 | Jan-65 | DUF724 superfamily |
| pfam06005 | Jul-58 | DUF904 |
| cl11531 | Jul-58 | DUF904 superfamily |
| cd14697 | 25-64 | bZIP_Maf |
| cl21462 | 25-64 | bZIP superfamily |
| PLN02610 | 140-312 | PLN02610 |
| PRK00133 | 151-251 | metG |
| PRK12267 | 151-251 | PRK12267 |
| TIGR00399 | 151-251 | metG_C_term |
| TIGR00472 | 159-232 | pheT_bact |
| PRK00629 | 159-232 | pheT |
| PRK05431 | Mar-79 | PRK05431 |
| PRK00252 | 15-78 | alaS |
| TIGR04211 | Jan-73 | SH3_and_anchor |
| pfam04111 | 18-72 | APG6 |
| pfam09731 | Feb-72 | Mitofilin |
| pfam04111 | Aug-72 | APG6 |
| PRK05561 | Aug-65 | PRK05561 |
| COG2517 | 155-226 | COG2517 |
| COG0013 | 22-78 | AlaS |
| PRK12704 | Sep-70 | PRK12704 |
| pfam04111 | May-72 | APG6 |
| COG2433 | Jan-70 | COG2433 |
| pfam13514 | 18-91 | AAA_27 |
| pfam15035 | May-72 | Rootletin |
| PRK13902 | Oct-73 | alaS |
| TIGR03825 | Nov-74 | FliH_bacil |
Ontology Information
| HPRD ID | 5371 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.