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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GPR56 | 9289 | G protein-coupled receptor 56  | 16 | BFPP; TM7LN4; TM7XN1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22968445    | 2012 | Cell line : - Source : Department of Pathology of Wrocaw Medical University. Sample Type : - No. of Sample : - Stage : TNM Stage II | Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation. | Up-regulation | 6.1 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class B : Orphans |
| Description | This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]   |
| Chromosome | 16 |
| Location | 16q13 |
| Start | 57619535   |
| End | 57665039   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 45505   |
| OMIM ID | 604110    |
| HGNC ID | HGNC:4512    |
| Unigene ID | Hs.513633     |
| Ensembl ID | ENSG00000205336    |
| PharmGKB ID | PA28901    |
mRNA Information
| mRNA ID | XM_006721340.2 |
|---|---|
| Exon | join(1..347,22057..22174,30719..30817,31651..32088, 33669..33801,34452..34599,35865..35996,36342..36458, 36692..36737,36980..37083,37839..37957,39861..40147, 41234..41342,42163..42431,43918..45494)   | mRNA Sequence |    Download   Select all |
| Length | 4043   |
CDS Information
| Location | join(30754..30817,31651..32088,33669..33801,34452..34599, 35865..35996,36342..36458,36692..36737,36980..37083, 37839..37957,39861..40147,41234..41342,42163..42431, 43918..44048) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001139243.1 |
|---|---|
| Protein Name | G protein-coupled receptor 56 |
| Molecular Wt. (Da) | 75027 |
| Protein Sequence |    Download   Select all |
| Length | 693   |
| Uniprot ID | P15502 |    
| Ensembl Protein ID | ENSP00000252034   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 688;- |
| S | Phosphorylation | 687;- |
| S | Phosphorylation | 681;- |
| T | Phosphorylation | 682;- |
| S | Phosphorylation | 681;- |
| T | Phosphorylation | 682;- |
| S | Phosphorylation | 689;- |
| S | Phosphorylation | 690;- |
| S | Phosphorylation | 683;- |
| S | Phosphorylation | 684;- |
| S | Phosphorylation | 683;- |
| S | Phosphorylation | 684;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00002 | 403-654  | 7tm_2 |
| cl21587 | 403-654  | 7tm_2 superfamily |
| pfam01825 | 343-389  | GPS |
| cl02559 | 343-389  | GPS superfamily |
| smart00303 | 342-389  | GPS |
Ontology Information
| HPRD ID | 2704 |    
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Deoxyribonuclease activity (GO:0004536) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
