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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GPR56 9289 G protein-coupled receptor 56  16BFPP; TM7LN4; TM7XN1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22968445   2012Cell line : -

Source : Department of Pathology of Wrocaw Medical University.

Sample Type : -

No. of Sample : -

Stage : TNM Stage II

Laser capture microdissection,FFPE-FASP,SAX fractionation,LC-MSMS,Label-free quantitation.Up-regulation6.1-


Gene Details



Chromosome: 16; NC_000016.9 (57653910..57698944)

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Gene Type protein coding
Gene Family GPCR / Class B : Orphans
Description This gene encodes a member of the G protein-coupled receptor family. The protein contains 7 transmembrane domains and a mucin-like domain in the N-terminal region. The gene is implicated in the regulation of brain cortical patterning. The protein binds specifically to transglutaminase 2 in the extracellular space. Expression of this gene is downregulated in melanoma cell lines, and overexpression of this gene can suppress tumor growth and metastasis. Mutations in this gene result in bilateral frontoparietal polymicrogyria. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]  
Chromosome 16
Location 16q13
Start 57619535  
End 57665039  
Strand +  
Gene Sequence

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Length 45505  
OMIM ID 604110   
HGNC ID HGNC:4512   
Unigene ID Hs.513633    
Ensembl ID ENSG00000205336   
PharmGKB ID PA28901   

mRNA Information


mRNA ID XM_006721340.2
Exon join(1..347,22057..22174,30719..30817,31651..32088, 33669..33801,34452..34599,35865..35996,36342..36458, 36692..36737,36980..37083,37839..37957,39861..40147, 41234..41342,42163..42431,43918..45494)  
mRNA Sequence

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Length 4043  



CDS Information


   
Locationjoin(30754..30817,31651..32088,33669..33801,34452..34599, 35865..35996,36342..36458,36692..36737,36980..37083, 37839..37957,39861..40147,41234..41342,42163..42431, 43918..44048)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001139243.1
Protein NameG protein-coupled receptor 56
Molecular Wt. (Da)75027
Protein Sequence

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Length 693  
Uniprot IDP15502
Ensembl Protein ID ENSP00000252034  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation688;-
SPhosphorylation687;-
SPhosphorylation681;-
TPhosphorylation682;-
SPhosphorylation681;-
TPhosphorylation682;-
SPhosphorylation689;-
SPhosphorylation690;-
SPhosphorylation683;-
SPhosphorylation684;-
SPhosphorylation683;-
SPhosphorylation684;-

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam00002403-654  7tm_2
cl21587403-654  7tm_2 superfamily
pfam01825343-389  GPS
cl02559343-389  GPS superfamily
smart00303342-389  GPS


Ontology Information


   
HPRD ID2704
Molecular ClassG protein coupled receptor
Molecular FunctionDeoxyribonuclease activity (GO:0004536)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO