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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SOCS6 9306 suppressor of cytokine signaling 6  18CIS4, SSI4, HSPC060, STATI4, STAI4, Cish4 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25025962   2014Cell line : -

Source : ATCC or the German Collection of Microorganisms and Cell Cultures (DSMZ, Braunschweig, Germany)

Sample Type : CRC tumor

No. of Sample : -

Stage : -

Tissue processing and laser microdissection,real-time PCR,Methylation analysis,Western blotting,ImmunohistochemistryDown-regulation-SOCS2 and SOCS6 levels are reduced in CRC and may serve as diagnostic biomarkers for CRC patients.


Gene Details



NC_000018.9 (67956137..67997435)

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Gene Type protein coding
Gene Family Suppressors of cytokine signaling, "SH2 domain containing"
Description The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]  
Chromosome 18
Location 18q22
Start 67956137  
End 67997435  
Strand +  
Gene Sequence

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Length 41299  
OMIM ID 605118   
HGNC ID HGNC:16833   
Unigene ID Hs.44439   
Ensembl ID ENSG00000170677   
PharmGKB ID PA134917653   

mRNA Information


mRNA ID ?NM_004232.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS11998.1



Protein Information


      
Protein IDNP_004223.2
Protein Namesuppressor of cytokine signaling 6
Molecular Wt. (Da)0
Protein Sequence

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Length 535  
Uniprot IDQ14687
Ensembl Protein ID ENSP00000253458  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
5296PIK3R24404NP_005018.1in vitro12052866   
6921TCEB12875NP_005639.1in vitro12052866   
6923TCEB22874NP_996896.1in vitro12052866   
7046TGFBR11822NP_004603.1in vivo15761153   
8471IRS44620NP_003595.1in vitro12052866   
8660IRS22878NP_003740.2in vitro12052866   
10616RBCK116643NP_112506.2in vivo;yeast 2-hybrid16643902   


Pathway Information


            
Pathway Name Pathway ID
Jak-STAT signaling pathway hsa04630
Prolactin signaling pathway hsa04917


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd10387373-472  SH2_SOCS6
cl15255373-472  SH2 superfamily
cd03740495-535  SOCS_SOCS6
cl02533495-535  SOCS superfamily
cd09923383-460  SH2_SOCS_family
cd10388376-472  SH2_SOCS7
smart00252382-460  SH2
cd09942379-496  SH2_nSH2_p85_like
cd00173384-460  SH2
cd03717496-533  SOCS_SOCS_like
cd03741496-535  SOCS_SOCS7
smart00253491-533  SOCS
cd10718379-460  SH2_CIS
cd10386385-460  SH2_SOCS5
cd10383376-467  SH2_SOCS2
cd10385375-460  SH2_SOCS4
cd10384376-460  SH2_SOCS3
cd03587496-533  SOCS
pfam00017384-460  SH2
cd10382373-462  SH2_SOCS1
cd09940379-465  SH2_Vav_family
pfam07525497-531  SOCS_box
cd09932382-460  SH2_C-SH2_PLC_gamma_like
cd09937384-471  SH2_csk_like
smart00969498-533  SOCS_box
cd09935381-466  SH2_ABL
cd03716496-531  SOCS_ASB_like
cd10405384-464  SH2_Vav1
cd09945382-491  SH2_SHB_SHD_SHE_SHF_like
cd10357372-434  SH2_ShkD_ShkE
cd10409382-472  SH2_Nck2
cd10352385-445  SH2_a2chimerin_b2chimerin
cd03739499-535  SOCS_SOCS5
cd10360384-433  SH2_Srm
cd10370382-466  SH2_Src_Src42
cd10354384-460  SH2_Cterm_RasGAP
cd09941384-460  SH2_Grb2_like
cd10351384-459  SH2_SH2D4B
cd03736499-535  SOCS_SOCS2
cd09933384-440  SH2_Src_family
cd10347384-460  SH2_Nterm_shark_like
cd09929373-412  SH2_BLNK_SLP-76
cd03738499-535  SOCS_SOCS4
cd09943382-460  SH2_Nck_family
cd09930384-460  SH2_cSH2_p85_like
cd09926381-421  SH2_CRK_like
cd03733496-530  SOCS_WSB_SWIP
cd10408384-472  SH2_Nck1
cd10355374-442  SH2_DAPP1_BAM32_like
cd10356374-442  SH2_ShkA_ShkC
cd10402381-444  SH2_C-SH2_Zap70
cd10349384-460  SH2_SH2D2A_SH2D7
cd10343382-433  SH2_SHIP
cd10392382-491  SH2_SHF
cd03746496-530  SOCS_WSB1_SWIP1
cd10407382-464  SH2_Vav3
cd10391382-491  SH2_SHE
cd03726496-533  SOCS_ASB7
cd03734497-532  SOCS_CIS1
cd03730497-535  SOCS_ASB14
cd10364384-466  SH2_Src_Lyn
cd09944382-459  SH2_Grb7_family
cd10390382-432  SH2_SHD
cd10341391-460  SH2_N-SH2_PLC_gamma_like
cd03723495-530  SOCS_ASB4_ASB18
cd09938384-466  SH2_N-SH2_Zap70_Syk_like
cd10417384-460  SH2_SH2D7
cd10337379-510  SH2_BCAR3
cd10369384-433  SH2_Src_Frk
cd10365384-432  SH2_Src_Src
cd03718499-531  SOCS_SSB1_4
cd10367384-472  SH2_Src_Fgr
cd03724498-531  SOCS_ASB5
cd10389382-440  SH2_SHB
cd03745497-530  SOCS_WSB2_SWIP2
cd09931384-460  SH2_C-SH2_SHP_like
cd10344383-435  SH2_SLAP
cd10350384-460  SH2_SH2D4A
cd10348384-466  SH2_Cterm_shark_like
cd10418384-435  SH2_Src_Fyn_isoform_a_like
cd10368384-423  SH2_Src_Fyn
cd10414382-459  SH2_Grb14
cd03721498-531  SOCS_ASB2
cd09925379-419  SH2_SHC
cd03729498-530  SOCS_ASB13
cd03725499-534  SOCS_ASB6
cd09946384-458  SH2_HSH2_like


Ontology Information


   
HPRD ID6300
Molecular ClassAdapter molecule
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO