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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24771466 | 2014 | Cell line : - Source : - Sample Type : Paraffin-embedded CRC tissue No. of Sample : primary tumors and normal colorectal mucosa of 75 patients with colorectal carcinoma. Stage : TNM Stage I-IV. | Immunostaining | Up-regulation | - | The expression of macrophage phenotype in colorectal cancer cells is associated with macrophage density in tumor stroma and lower survival rates. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| Chromosome | 12 |
| Location | 12p13 |
| Start | 7623412 |
| End | 7656414 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 33003 |
| OMIM ID | 605545 |
| HGNC ID | HGNC:1631 |
| Unigene ID | Hs.504641 |
| Ensembl ID | ENSG00000177575 |
| PharmGKB ID | PA26190 |
Protein Information
| Protein ID | NP_004235.4 |
|---|---|
| Protein Name | CD163 molecule |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1156 |
| Uniprot ID | Q9BYZ6 |
| Ensembl Protein ID | ENSP00000251822 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 270 |
| R | Proteolytic Cleavage | 282 |
| S | Proteolytic Cleavage | 334 |
| A | Proteolytic Cleavage | 361 |
| D | Proteolytic Cleavage | 270 |
| R | Proteolytic Cleavage | 282 |
| S | Proteolytic Cleavage | 334 |
| A | Proteolytic Cleavage | 361 |
| T | Phosphorylation | 1072 |
| S | Phosphorylation | 1084 |
| T | Phosphorylation | 1072 |
| S | Phosphorylation | 1084 |
| S | Phosphorylation | 1085 |
| S | Phosphorylation | 1085 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3240 | HP | 772 | NP_005134.1 | in vivo | 11854028 |
| 4627 | MYH9 | 1177 | NP_002464.1 | in vivo | 15479433 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00202 | 719-819 | SR |
| cl02509 | 719-819 | SRCR superfamily |
| smart00202 | 159-259 | SR |
| cl02509 | 159-259 | SRCR superfamily |
| smart00202 | 266-366 | SR |
| cl02509 | 266-366 | SRCR superfamily |
| smart00202 | 51-152 | SR |
| cl02509 | 51-152 | SRCR superfamily |
| smart00202 | 929-1029 | SR |
| cl02509 | 929-1029 | SRCR superfamily |
| pfam00530 | 722-819 | SRCR |
| pfam00530 | 934-1029 | SRCR |
| smart00202 | 479-578 | SR |
| cl02509 | 479-578 | SRCR superfamily |
| pfam00530 | 164-259 | SRCR |
| pfam00530 | 269-366 | SRCR |
| smart00202 | 583-683 | SR |
| cl02509 | 583-683 | SRCR superfamily |
| smart00202 | 373-473 | SR |
| cl02509 | 373-473 | SRCR superfamily |
| pfam00530 | 54-152 | SRCR |
| pfam00530 | 481-578 | SRCR |
| pfam00530 | 586-683 | SRCR |
| pfam00530 | 376-473 | SRCR |
| pfam00530 | 835-925 | SRCR |
| cl02509 | 835-925 | SRCR superfamily |
Ontology Information
| HPRD ID | 12457 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q86VB7 | DB05389 | WF10 | SmallMoleculeDrug |