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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
SLIT2 9353 Slit homolog 2 (Drosophila)  4SLIL3; Slit-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
12615722   2003Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 32 CRC samples and their matching histologically normal mucosa and6 colorectal tumor cell lines

Stage : -

Bisulfite Modification and Methylation Analysis, Microsatellite RMethylation-SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer.

SLIT2 promoter region methylation was found in 23 (72%) of 32 primary colorectal cancers.

15534609   2004Cell line : SW48, HCT116, LS411, LS174T, DLD1, LoVo

Source : -

Sample Type : -

No. of Sample : 32 colorectal cancer samples and normal mucosa

Stage : -

Bisulphite modification and methylation analysis, Combined bisulphite restriction analysis (COBRA) Methylation-SLIT2 and SLIT3 are frequently methylated in gliomas and colorectal cancers.

22532293   2013Cell line : -

Source : -

Sample Type : CRC tumor, normal tissue and stool sample

No. of Sample : 60 patients CRC, 32 patients with IBD-associated neoplasia, 85 patients with IBD without associated neoplasia (20 at high risk and 65 at low risk), and 28 healthy controls and 16stool sample

Stage : -

Methylation-specific melting curve analysisMethylation-Analysis of TGFB2, SLIT2, HS3ST2, and TMEFF2 genes methylation markers may help in the early identification of colorectal dysplasia or cancer in high-risk IBD patients.

In stool samples, only SLIT2 gene methylation was more frequently methylated in the group of patients at high risk of dysplasia or cancer (4/16) compared to low risk (0/37).

23010642   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : 120 CRC cases

Stage : -

DNA methylation assay and K-means clustering analysis.Methylation-Methylation of the PCGT genes along with RASSF1A, APC, and MGMT can be potentially used as a new biomarker for the classification and prognosis of CRC tumors and SLIT2 gene is member of PCGT genes.

21283129   2011Cell line : SW 620, SW 480, LS 180, LS 174T, Lovo, Caco 2,SW 48, HCT 116, HT 29 and DLD 1

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Cell cultures, stable cell lines and treatment, Immunoblotting, immunoprecipeitation, GST Pull Down assayUnknown-Expression of Slit2 and Robo1 was significantly associated with an increased metastatic risk and poorer overall survival in colorectal carcinoma patients.

Engagement of Robo1 by Slit2 induces malignant transformation through Hakai-mediated E-cad ubiquitination and lysosomal degradation during colorectal epithelial cell carcinogenesis.

Elevated Slit2 secretion or Robo1 and Slit2 expression was seen in the supernatants and lysates of six cell lines: SW620, SW480, LS180, LS174T, Lovo and Caco2 cells. However, neither Robo1 nor Slit2 secretion/expression was evident in the other four cell lines; SW48, HCT116, HT29 and DLD1 cells.


Gene Details



Chromosome: 4; NC_000004.11 (20255235..20620788)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 4
Location 4p15.2
Start 20251925  
End 20620561  
Strand +  
Gene Sequence

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Length 368637  
OMIM ID 603746   
HGNC ID HGNC:11086   
Unigene ID Hs.29802   
Ensembl ID ENSG00000145147   
PharmGKB ID -   

mRNA Information


mRNA ID XM_005248211.2
Exon join(1..2070,4748..4819,5944..6015,16886..16957, 215828..215899,228792..228863,234276..234347, 236895..237058,238879..238890,239837..239975, 258571..258642,259142..259213,267458..267529, 271836..271979,272090..272253,273225..273248, 277025..277175,280060..280134,281648..281791, 287517..287660,289529..289695,290570..290702, 294107..294175,296564..296635,297133..297204, 298903..298974,301881..302044,315338..315462, 315594..315691,316941..317080,337720..337813, 343773..343910,344491..344731,346341..346471, 358089..358243,364986..365274,365515..365726, 366844..368637)  
mRNA Sequence

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Length 8045  



CDS Information


   
Location join(1892..2070,4748..4819,5944..6015,16886..16957, 215828..215899,228792..228863,234276..234347, 236895..237058,238879..238890,239837..239975, 258571..258642,259142..259213,267458..267529, 271836..271979,272090..272253,273225..273248, 277025..277175,280060..280134,281648..281791, 287517..287660,289529..289695,290570..290702, 294107..294175,296564..2
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001276064.1
Protein NameSlit homolog 2 (Drosophila)
Molecular Wt. (Da)167483
Protein Sequence

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Length 1525  
Uniprot IDQ05925
Ensembl Protein ID ENSP00000295206  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RProteolytic Cleavage1121

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2817GPC12671NP_002072.2in vitro;in vivo1   137   598   010   364   230   
6091ROBO13890NP_002932.1in vivo10102268   


Pathway Information


      
Pathway Name Pathway ID
Axon guidance hsa04360


Structure Information


PDB ID1QMV
Resolution1.7
MethodX-RAY DIFFRACTION
Chains A,b,C  
Molecule PEROXIREDOXIN-2  
Model View



Domain Information




ID Location Description
cd001101161-1314  LamG
cl228611161-1314  LamG superfamily
cd000541076-1112  EGF_CA
cl215041076-1112  EGF_CA superfamily
cd00054998-1034  EGF_CA
cl21504998-1034  EGF_CA superfamily
cd000541038-1073  EGF_CA
cl215041038-1073  EGF_CA superfamily
cd00054964-996  EGF_CA
cl21504964-996  EGF_CA superfamily
cd000541130-1157  EGF_CA
cl215041130-1157  EGF_CA superfamily
smart002821183-1316  LamG
pfam022101190-1316  Laminin_G_2
pfam000541188-1319  Laminin_G_1
smart00082859-908  LRRCT
cl15307859-908  LRRCT superfamily
smart0001327-58  LRRNT
cl0242327-58  LRRNT superfamily
smart001791076-1112  EGF_CA
cd0011643-214  LRR_RI
cl2370743-214  LRR_RI superfamily
smart00013727-758  LRRNT
cl02423727-758  LRRNT superfamily
smart00179998-1034  EGF_CA
smart00082209-258  LRRCT
cl15307209-258  LRRCT superfamily
smart00013272-304  LRRNT
cl02423272-304  LRRNT superfamily
pfam12799324-364  LRR_4
cl19302324-364  LRR_4 superfamily
pfam0146227-54  LRRNT
pfam12799777-818  LRR_4
cl19302777-818  LRR_4 superfamily
pfam01462272-299  LRRNT
smart00082664-713  LRRCT
cl15307664-713  LRRCT superfamily
pfam12799537-574  LRR_4
cl19302537-574  LRR_4 superfamily
pfam000081081-1110  EGF
pfam000081042-1072  EGF
smart00013505-535  LRRNT
cl02423505-535  LRRNT superfamily
smart00082430-460  LRRCT
cl15307430-460  LRRCT superfamily
cd000531081-1112  EGF
pfam01462727-753  LRRNT
cd0011659-214  LRR_RI
pfam12799757-794  LRR_4
cl19302757-794  LRR_4 superfamily
pfam1279958-95  LRR_4
cl1930258-95  LRR_4 superfamily
cd000531003-1034  EGF
pfam01462505-532  LRRNT
cd0011658-164  LRR_RI
cd00116390-646  LRR_RI
cl23707390-646  LRR_RI superfamily
smart001791038-1074  EGF_CA
cd000531045-1072  EGF
pfam12799801-853  LRR_4
cl19302801-853  LRR_4 superfamily
pfam000081003-1031  EGF
smart00370325-346  LRR
cl19480325-346  LRR superfamily
smart00369325-346  LRR_TYP
cl19479325-346  LRR_TYP superfamily
pfam13855778-837  LRR_8
pfam13855302-360  LRR_8
pfam13855153-211  LRR_8
pfam1385555-115  LRR_8
pfam13855582-642  LRR_8
pfam13855537-594  LRR_8
TIGR00864832-1013  PCC
TIGR00864637-713  PCC
COG488656-211  LRR
pfam13855606-666  LRR_8
pfam13855801-861  LRR_8
COG4886515-699  LRR
pfam1385579-139  LRR_8
PRK15370523-831  PRK15370
COG488645-353  LRR
pfam13855325-408  LRR_8
COG4886519-861  LRR
PLN03150769-838  PLN03150
PRK15370733-861  PRK15370
pfam13855756-813  LRR_8
PLN0011355-211  PLN00113
pfam13855128-187  LRR_8
PLN00113322-863  PLN00113
PRK15370287-367  PRK15370
PRK15370290-411  PRK15370
TIGR00864182-319  PCC
PRK15370103-367  PRK15370
pfam13855382-432  LRR_8
pfam14580529-644  LRR_9
PRK1537046-190  PRK15370
PLN0011355-367  PLN00113
TIGR00864403-466  PCC
COG4886297-667  LRR
PLN0011349-408  PLN00113
COG488637-220  LRR
PRK15387279-364  PRK15387
pfam06247982-1108  Plasmod_Pvs28
pfam13306291-370  LRR_5
pfam13306560-664  LRR_5
pfam13306302-370  LRR_5


Ontology Information


   
HPRD ID6787
Molecular ClassLigand
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO