Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLIT2 | 9353 | Slit homolog 2 (Drosophila)  | 4 | SLIL3; Slit-2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12615722    | 2003 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 32 CRC samples and their matching histologically normal mucosa and6 colorectal tumor cell lines Stage : - | Bisulfite Modification and Methylation Analysis, Microsatellite R | Methylation | - | SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer. SLIT2 promoter region methylation was found in 23 (72%) of 32 primary colorectal cancers. |
| 15534609    | 2004 | Cell line : SW48, HCT116, LS411, LS174T, DLD1, LoVo Source : - Sample Type : - No. of Sample : 32 colorectal cancer samples and normal mucosa Stage : - | Bisulphite modification and methylation analysis, Combined bisulphite restriction analysis (COBRA) | Methylation | - | SLIT2 and SLIT3 are frequently methylated in gliomas and colorectal cancers. |
| 22532293    | 2013 | Cell line : - Source : - Sample Type : CRC tumor, normal tissue and stool sample No. of Sample : 60 patients CRC, 32 patients with IBD-associated neoplasia, 85 patients with IBD without associated neoplasia (20 at high risk and 65 at low risk), and 28 healthy controls and 16stool sample Stage : - | Methylation-specific melting curve analysis | Methylation | - | Analysis of TGFB2, SLIT2, HS3ST2, and TMEFF2 genes methylation markers may help in the early identification of colorectal dysplasia or cancer in high-risk IBD patients. In stool samples, only SLIT2 gene methylation was more frequently methylated in the group of patients at high risk of dysplasia or cancer (4/16) compared to low risk (0/37). |
| 23010642    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : 120 CRC cases Stage : - | DNA methylation assay and K-means clustering analysis. | Methylation | - | Methylation of the PCGT genes along with RASSF1A, APC, and MGMT can be potentially used as a new biomarker for the classification and prognosis of CRC tumors and SLIT2 gene is member of PCGT genes. |
| 21283129    | 2011 | Cell line : SW 620, SW 480, LS 180, LS 174T, Lovo, Caco 2,SW 48, HCT 116, HT 29 and DLD 1 Source : - Sample Type : - No. of Sample : - Stage : - | Cell cultures, stable cell lines and treatment, Immunoblotting, immunoprecipeitation, GST Pull Down assay | Unknown | - | Expression of Slit2 and Robo1 was significantly associated with an increased metastatic risk and poorer overall survival in colorectal carcinoma patients. Engagement of Robo1 by Slit2 induces malignant transformation through Hakai-mediated E-cad ubiquitination and lysosomal degradation during colorectal epithelial cell carcinogenesis. Elevated Slit2 secretion or Robo1 and Slit2 expression was seen in the supernatants and lysates of six cell lines: SW620, SW480, LS180, LS174T, Lovo and Caco2 cells. However, neither Robo1 nor Slit2 secretion/expression was evident in the other four cell lines; SW48, HCT116, HT29 and DLD1 cells. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | -   |
| Chromosome | 4 |
| Location | 4p15.2 |
| Start | 20251925   |
| End | 20620561   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 368637   |
| OMIM ID | 603746    |
| HGNC ID | HGNC:11086    |
| Unigene ID | Hs.29802    |
| Ensembl ID | ENSG00000145147    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_005248211.2 |
|---|---|
| Exon | join(1..2070,4748..4819,5944..6015,16886..16957, 215828..215899,228792..228863,234276..234347, 236895..237058,238879..238890,239837..239975, 258571..258642,259142..259213,267458..267529, 271836..271979,272090..272253,273225..273248, 277025..277175,280060..280134,281648..281791, 287517..287660,289529..289695,290570..290702, 294107..294175,296564..296635,297133..297204, 298903..298974,301881..302044,315338..315462, 315594..315691,316941..317080,337720..337813, 343773..343910,344491..344731,346341..346471, 358089..358243,364986..365274,365515..365726, 366844..368637)   | mRNA Sequence |    Download   Select all |
| Length | 8045   |
CDS Information
| Location | join(1892..2070,4748..4819,5944..6015,16886..16957, 215828..215899,228792..228863,234276..234347, 236895..237058,238879..238890,239837..239975, 258571..258642,259142..259213,267458..267529, 271836..271979,272090..272253,273225..273248, 277025..277175,280060..280134,281648..281791, 287517..287660,289529..289695,290570..290702, 294107..294175,296564..2 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001276064.1 |
|---|---|
| Protein Name | Slit homolog 2 (Drosophila) |
| Molecular Wt. (Da) | 167483 |
| Protein Sequence |    Download   Select all |
| Length | 1525   |
| Uniprot ID | Q05925 |    
| Ensembl Protein ID | ENSP00000295206   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 1121 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2817 |    GPC1 |    2671 |    NP_002072.2 |    in vitro;in vivo |    1   137   598   010   364   230    |
| 6091 |    ROBO1 |    3890 |    NP_002932.1 |    in vivo |    10102268    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance |    hsa04360 |    
Structure Information
| PDB ID | 1QMV |
|---|---|
| Resolution | 1.7 |
| Method | X-RAY DIFFRACTION |
| Chains | A,b,C   |
| Molecule | PEROXIREDOXIN-2   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00110 | 1161-1314  | LamG |
| cl22861 | 1161-1314  | LamG superfamily |
| cd00054 | 1076-1112  | EGF_CA |
| cl21504 | 1076-1112  | EGF_CA superfamily |
| cd00054 | 998-1034  | EGF_CA |
| cl21504 | 998-1034  | EGF_CA superfamily |
| cd00054 | 1038-1073  | EGF_CA |
| cl21504 | 1038-1073  | EGF_CA superfamily |
| cd00054 | 964-996  | EGF_CA |
| cl21504 | 964-996  | EGF_CA superfamily |
| cd00054 | 1130-1157  | EGF_CA |
| cl21504 | 1130-1157  | EGF_CA superfamily |
| smart00282 | 1183-1316  | LamG |
| pfam02210 | 1190-1316  | Laminin_G_2 |
| pfam00054 | 1188-1319  | Laminin_G_1 |
| smart00082 | 859-908  | LRRCT |
| cl15307 | 859-908  | LRRCT superfamily |
| smart00013 | 27-58  | LRRNT |
| cl02423 | 27-58  | LRRNT superfamily |
| smart00179 | 1076-1112  | EGF_CA |
| cd00116 | 43-214  | LRR_RI |
| cl23707 | 43-214  | LRR_RI superfamily |
| smart00013 | 727-758  | LRRNT |
| cl02423 | 727-758  | LRRNT superfamily |
| smart00179 | 998-1034  | EGF_CA |
| smart00082 | 209-258  | LRRCT |
| cl15307 | 209-258  | LRRCT superfamily |
| smart00013 | 272-304  | LRRNT |
| cl02423 | 272-304  | LRRNT superfamily |
| pfam12799 | 324-364  | LRR_4 |
| cl19302 | 324-364  | LRR_4 superfamily |
| pfam01462 | 27-54  | LRRNT |
| pfam12799 | 777-818  | LRR_4 |
| cl19302 | 777-818  | LRR_4 superfamily |
| pfam01462 | 272-299  | LRRNT |
| smart00082 | 664-713  | LRRCT |
| cl15307 | 664-713  | LRRCT superfamily |
| pfam12799 | 537-574  | LRR_4 |
| cl19302 | 537-574  | LRR_4 superfamily |
| pfam00008 | 1081-1110  | EGF |
| pfam00008 | 1042-1072  | EGF |
| smart00013 | 505-535  | LRRNT |
| cl02423 | 505-535  | LRRNT superfamily |
| smart00082 | 430-460  | LRRCT |
| cl15307 | 430-460  | LRRCT superfamily |
| cd00053 | 1081-1112  | EGF |
| pfam01462 | 727-753  | LRRNT |
| cd00116 | 59-214  | LRR_RI |
| pfam12799 | 757-794  | LRR_4 |
| cl19302 | 757-794  | LRR_4 superfamily |
| pfam12799 | 58-95  | LRR_4 |
| cl19302 | 58-95  | LRR_4 superfamily |
| cd00053 | 1003-1034  | EGF |
| pfam01462 | 505-532  | LRRNT |
| cd00116 | 58-164  | LRR_RI |
| cd00116 | 390-646  | LRR_RI |
| cl23707 | 390-646  | LRR_RI superfamily |
| smart00179 | 1038-1074  | EGF_CA |
| cd00053 | 1045-1072  | EGF |
| pfam12799 | 801-853  | LRR_4 |
| cl19302 | 801-853  | LRR_4 superfamily |
| pfam00008 | 1003-1031  | EGF |
| smart00370 | 325-346  | LRR |
| cl19480 | 325-346  | LRR superfamily |
| smart00369 | 325-346  | LRR_TYP |
| cl19479 | 325-346  | LRR_TYP superfamily |
| pfam13855 | 778-837  | LRR_8 |
| pfam13855 | 302-360  | LRR_8 |
| pfam13855 | 153-211  | LRR_8 |
| pfam13855 | 55-115  | LRR_8 |
| pfam13855 | 582-642  | LRR_8 |
| pfam13855 | 537-594  | LRR_8 |
| TIGR00864 | 832-1013  | PCC |
| TIGR00864 | 637-713  | PCC |
| COG4886 | 56-211  | LRR |
| pfam13855 | 606-666  | LRR_8 |
| pfam13855 | 801-861  | LRR_8 |
| COG4886 | 515-699  | LRR |
| pfam13855 | 79-139  | LRR_8 |
| PRK15370 | 523-831  | PRK15370 |
| COG4886 | 45-353  | LRR |
| pfam13855 | 325-408  | LRR_8 |
| COG4886 | 519-861  | LRR |
| PLN03150 | 769-838  | PLN03150 |
| PRK15370 | 733-861  | PRK15370 |
| pfam13855 | 756-813  | LRR_8 |
| PLN00113 | 55-211  | PLN00113 |
| pfam13855 | 128-187  | LRR_8 |
| PLN00113 | 322-863  | PLN00113 |
| PRK15370 | 287-367  | PRK15370 |
| PRK15370 | 290-411  | PRK15370 |
| TIGR00864 | 182-319  | PCC |
| PRK15370 | 103-367  | PRK15370 |
| pfam13855 | 382-432  | LRR_8 |
| pfam14580 | 529-644  | LRR_9 |
| PRK15370 | 46-190  | PRK15370 |
| PLN00113 | 55-367  | PLN00113 |
| TIGR00864 | 403-466  | PCC |
| COG4886 | 297-667  | LRR |
| PLN00113 | 49-408  | PLN00113 |
| COG4886 | 37-220  | LRR |
| PRK15387 | 279-364  | PRK15387 |
| pfam06247 | 982-1108  | Plasmod_Pvs28 |
| pfam13306 | 291-370  | LRR_5 |
| pfam13306 | 560-664  | LRR_5 |
| pfam13306 | 302-370  | LRR_5 |
Ontology Information
| HPRD ID | 6787 |    
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
