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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16530191 | 2006 | Cell line : - Source : Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Western blotting | Up-regulation | - | High expression of NMT2 in human colorectal adenocarcinomas and the interaction of both forms of NMT with various signaling molecules. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| Chromosome | 10 |
| Location | 10p13 |
| Start | 15147771 |
| End | 15210703 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 62933 |
| OMIM ID | 603801 |
| HGNC ID | HGNC:7858 |
| Unigene ID | Bt.249 |
| Ensembl ID | ENSG00000152465 |
| PharmGKB ID | PA31662 |
Protein Information
| Protein ID | NP_001295224.1 |
|---|---|
| Protein Name | N-myristoyltransferase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 498 |
| Uniprot ID | Q96RL7 |
| Ensembl Protein ID | ENSP00000349985 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 38 |
| T | Phosphorylation | 337 |
| S | Phosphorylation | 338 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 596 | BCL2 | 1045 | NP_000624.2 | in vivo | 16530191 |
| 836 | CASP3 | 2799 | NP_004337.2 | in vivo | 16530191 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 16530191 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02799 | 310-497 | NMT_C |
| cl03719 | 310-497 | NMT_C superfamily |
| pfam01233 | 138-296 | NMT |
| cl03135 | 138-296 | NMT superfamily |
| COG5092 | 119-486 | NMT1 |
Ontology Information
| HPRD ID | 16681 |
|---|---|
| Molecular Class | Enzyme: Transferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.