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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21210765 | 2011 | Cell line : DDL1, HCT116 Source : - Sample Type : - No. of Sample : - Stage : - | Cell cycle analysis,flow cytometry,Western blotting,Cell viability assay and clonogenic survival assay | Down-regulation | - | RECQL5 as a major determinant for CPT resistance in colorectal cancer cells and a potential candidate as a biomarker for irinotecan-based treatment for colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| Chromosome | 17 |
| Location | 17q25 |
| Start | 73622925 |
| End | 73663270 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 40346 |
| OMIM ID | 603781 |
| HGNC ID | HGNC:9950 |
| Unigene ID | Hs.632229 |
| Ensembl ID | ENSG00000108469 |
| PharmGKB ID | PA34317 |
Protein Information
| Protein ID | NP_001003715.1 |
|---|---|
| Protein Name | RecQ protein-like 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 991 |
| Uniprot ID | O60346 |
| Ensembl Protein ID | ENSP00000262719 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 815 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| S | Acetylation | 2 |
| T | Phosphorylation | 839 |
| S | Phosphorylation | 727 |
| T | Phosphorylation | 821 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1937 | EEF1G | 11745 | NP_001395.1 | yeast 2-hybrid | 16169070 |
| 7156 | TOP3A | 3145 | NP_004609.1 | in vitro;in vivo | 10710432 |
| 8940 | TOP3B | 4662 | NP_003926.1 | in vivo | 10710432 |
| 9479 | MAPK8IP1 | 5223 | NP_005447.1 | yeast 2-hybrid | 16169070 |
| 9788 | MTSS1 | 12243 | NP_055566.3 | yeast 2-hybrid | 16169070 |
| 10617 | STAMBP | 5877 | NP_006454.1 | yeast 2-hybrid | 16169070 |
| 11325 | DDX42 | 9909 | NP_031398.2 | yeast 2-hybrid | 16169070 |
| 23421 | ITGB3BP | 9267 | NP_055103.3 | yeast 2-hybrid | 16169070 |
| 221442 | - | 17323 | NP_001010871.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00079 | 246-362 | HELICc |
| cl21455 | 246-362 | P-loop_NTPase superfamily |
| cd00046 | 46-194 | DEXDc |
| cl21455 | 46-194 | P-loop_NTPase superfamily |
| pfam06959 | 625-829 | RecQ5 |
| cl06146 | 625-829 | RecQ5 superfamily |
| pfam00270 | 31-201 | DEAD |
| smart00490 | 273-354 | HELICc |
| pfam00271 | 278-354 | Helicase_C |
| cd09710 | 37-160 | Cas3_I-D |
| smart00487 | 22-229 | DEXDc |
| COG0514 | 15-437 | RecQ |
| TIGR01389 | 17-446 | recQ |
| TIGR00614 | 18-434 | recQ_fam |
| PLN03137 | 6-434 | PLN03137 |
| PRK11057 | 6-448 | PRK11057 |
| COG0513 | 25-397 | SrmB |
| COG1205 | 7-357 | YprA |
| COG1202 | 31-354 | COG1202 |
| COG1201 | 20-352 | Lhr |
| COG1204 | 14-388 | BRR2 |
| PTZ00110 | 240-354 | PTZ00110 |
| TIGR03817 | 31-357 | DECH_helic |
| PHA03247 | 629-911 | PHA03247 |
| PTZ00424 | 263-355 | PTZ00424 |
| PHA03247 | 632-908 | PHA03247 |
| TIGR04121 | 53-357 | DEXH_lig_assoc |
| COG1061 | 32-194 | SSL2 |
| PRK14086 | 771-909 | dnaA |
| PHA03378 | 642-935 | PHA03378 |
| PLN00206 | 262-356 | PLN00206 |
| TIGR03158 | 37-128 | cas3_cyano |
| COG1203 | 20-207 | Cas3 |
| PHA03247 | 622-856 | PHA03247 |
| PRK12323 | 676-890 | PRK12323 |
| PRK07764 | 574-850 | PRK07764 |
Ontology Information
| HPRD ID | 16254 |
|---|---|
| Molecular Class | DNA helicase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.