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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17569141 | 2007 | Cell line : DLD 1 Caco 2, Lovo Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR,siRNA plasmid expression, Transfection,MTT and aggregation assay | Up-regulation | - | TTYH2 gene expression is significantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating and metastatic potentials of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q25.1 |
| Start | 72209696 |
| End | 72258159 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 48464 |
| OMIM ID | 608855 |
| HGNC ID | HGNC:13877 |
| Unigene ID | Hs.27935 |
| Ensembl ID | ENSG00000141540 |
| PharmGKB ID | PA37823 |
Protein Information
| Protein ID | NP_116035.5 |
|---|---|
| Protein Name | tweety family member 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 534 |
| Uniprot ID | Q86X40 |
| Ensembl Protein ID | ENSP00000304923 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 494 |
| Y | Phosphorylation | 173 |
| T | Phosphorylation | 199;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07912 | 7-422 | Tweety_N |
| cl12141 | 7-422 | Tweety_N superfamily |
| pfam04906 | 27-433 | Tweety |
Ontology Information
| HPRD ID | 10590 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.