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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TJP2 9414 Tight junction protein 2 (zona occludens 2)  9ZO2; X104; DFNA51; DUP9q21.11; C9DUPq21.11 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor, normal tissue and stool sample

No. of Sample : -

Stage : TNM Stage II

Biochemical isolation to nano-LC-MS/MS analysisUp-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.

CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands.


Gene Details



Chromosome: 9; NC_000009.11 (71736180..71870124)

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Gene Type protein coding
Gene Family -
Description This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]  
Chromosome 9
Location 9q13-q21
Start 69121264  
End 69255208  
Strand +  
Gene Sequence

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Length 133945  
OMIM ID 607709   
HGNC ID HGNC:11828   
Unigene ID Hs.50382    
Ensembl ID ENSG00000119139   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001170414.2
Exon join(1..102,30388..30508,91285..91338,95076..95200, 96994..97096,99624..100233,104041..104144,104759..104912, 106502..106610,106718..106851,107921..107987, 108819..108969,113176..113284,114765..114975, 115686..115873,116615..116710,117447..117526, 118674..118884,125427..125527,126749..126961, 131552..131637,132946..133945)  
mRNA Sequence

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Length 4129  



CDS Information


   
Location join(53110..53169,91285..91338,95076..95200,96994..97096, 99624..100233,104041..104144,104759..104912, 106502..106610,106718..106851,107921..107987, 108819..108969,113176..113284,114765..114975, 115686..115873,116615..116710,117447..117526, 118674..118884,125427..125527,126749..126961, 128112..128222,129772..130101,131552..131637, 132946..133111)
CDS Sequence

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CCDS ID CCDS6627.1



Protein Information


      
Protein IDNP_001163886.1
Protein NameTight junction protein 2 (zona occludens 2)
Molecular Wt. (Da)130316
Protein Sequence

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Length 1157  
Uniprot IDQ09472
Ensembl Protein ID ENSP00000263253  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation1118
SPhosphorylation1159
SPhosphorylation266
SPhosphorylation296
SPhosphorylation1012
SPhosphorylation266
SPhosphorylation296
YPhosphorylation971
YPhosphorylation261
YPhosphorylation261
SPhosphorylation266;-
SPhosphorylation266;-
SPhosphorylation174;-
SPhosphorylation174;-
SPhosphorylation130;-
SPhosphorylation130;-
SPhosphorylation986;-
SPhosphorylation978;-
SPhosphorylation979;-
SPhosphorylation966;-
SPhosphorylation1156;-
SPhosphorylation1009;-
YPhosphorylation1157;-
YPhosphorylation1010;-
SPhosphorylation1171;-
SPhosphorylation1024;-
SPhosphorylation1174;-
SPhosphorylation1027;-
SPhosphorylation168;-
SPhosphorylation170;-
SPhosphorylation168;-
SPhosphorylation170;-
SPhosphorylation394;-
SPhosphorylation398;-
SPhosphorylation394;-
SPhosphorylation398;-
SPhosphorylation400;-
SPhosphorylation400;-
SPhosphorylation410;-
SPhosphorylation406;-
SPhosphorylation413;-
SPhosphorylation410;-
SPhosphorylation406;-
SPhosphorylation413;-
SPhosphorylation192;-
SPhosphorylation192;-
SPhosphorylation440;-
SPhosphorylation440;-
SPhosphorylation441;-
SPhosphorylation441;-
TPhosphorylation445;-
TPhosphorylation445;-
SPhosphorylation244;-
SPhosphorylation244;-
SPhosphorylation424;-
YPhosphorylation423;-
SPhosphorylation424;-
YPhosphorylation423;-
SPhosphorylation432;-
YPhosphorylation428;-
SPhosphorylation432;-
YPhosphorylation428;-
SPhosphorylation770;-
TPhosphorylation771;-
SPhosphorylation770;-
TPhosphorylation771;-
SPhosphorylation431
SPhosphorylation431
SPhosphorylation430
SPhosphorylation430
TPhosphorylation455
TPhosphorylation455
SPhosphorylation920
TPhosphorylation925
TPhosphorylation933
SPhosphorylation920
TPhosphorylation925
TPhosphorylation933
YPhosphorylation932
YPhosphorylation932
SPhosphorylation961
SPhosphorylation1053
SPhosphorylation1067
TPhosphorylation1054
SPhosphorylation1068
TPhosphorylation1131
TPhosphorylation984
TPhosphorylation1027
SPhosphorylation415
SPhosphorylation415
SPhosphorylation702
SPhosphorylation702
YPhosphorylation427
YPhosphorylation427
SPhosphorylation163
SPhosphorylation163
SPhosphorylation196
SPhosphorylation196
TPhosphorylation494
YPhosphorylation506
TPhosphorylation510
TPhosphorylation494
YPhosphorylation506
TPhosphorylation510
SPhosphorylation1147
YPhosphorylation1150
SPhosphorylation1000
YPhosphorylation1003
YPhosphorylation32
YPhosphorylation32
TPhosphorylation35
TPhosphorylation35
SPhosphorylation913
SPhosphorylation913

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1495CTNNA1285NP_001894.2in vitro10026224   
2035EPB41558AAD42222.1in vitro;yeast 2-hybrid10874042   
4950OCLN4191NP_002529.1in vitro;in vivo1   451   243   110   575   000   
6294SAFB4205NP_002958.2in vitro;in vivo;yeast 2-hybrid12403786   
7082TJP13002NP_003248.3in vitro;in vivo75   422   591   096   686   600   000   000   
7532YWHAG5639NP_036611.2in vivo15324660   
9076CLDN14760NP_066924.1in vitro10601346   
30011SH3KBP12301NP_114098.1in vitro;in vivo12829691   


Pathway Information


            
Pathway Name Pathway ID
Tight junction hsa04530
Vibrio cholerae infection hsa05110


Structure Information


PDB ID1ZXA
Resolution-
Methodsolution NMR
Chains A,B  
Molecule cGMP-dependent protein kinase 1, alpha isozyme  
Model View



Domain Information




ID Location Description
cd12027604-666  SH3_ZO-2
cl17036604-666  SH3 superfamily
cd0099232-117  PDZ_signaling
cl0011732-117  PDZ superfamily
cd00992510-587  PDZ_signaling
cl00117510-587  PDZ superfamily
cd00992308-382  PDZ_signaling
cl00117308-382  PDZ superfamily
smart00072700-879  GuKc
cl17190700-879  NK superfamily
cd11859608-666  SH3_ZO
cd12026605-666  SH3_ZO-1
cd12028605-666  SH3_ZO-3
smart0022830-119  PDZ
pfam0059533-117  PDZ
smart00228516-587  PDZ
pfam00595517-589  PDZ
smart00228303-385  PDZ
cd00136519-575  PDZ
pfam00595299-382  PDZ
cd11860608-667  SH3_DLG5
cd0013642-117  PDZ
cd00136318-382  PDZ
cd00988521-586  PDZ_CTP_protease
pfam07653608-666  SH3_2
cd0098864-121  PDZ_CTP_protease
cd00987306-392  PDZ_serine_protease
pfam13180522-597  PDZ_2
cd00989338-386  PDZ_metalloprotease
cd00989520-571  PDZ_metalloprotease
cd00987532-597  PDZ_serine_protease
cd00988344-389  PDZ_CTP_protease
cd0098757-127  PDZ_serine_protease
smart00326605-660  SH3
cd0098965-128  PDZ_metalloprotease
cd12030607-666  SH3_DLG4
pfam06495167-217  Transformer
cl21734167-217  PRP38_assoc superfamily
pfam1318058-123  PDZ_2
pfam12871156-228  PRP38_assoc
pfam00625778-878  Guanylate_kin
COG0793499-586  CtpA
TIGR01642144-226  U2AF_lg
TIGR01622167-223  SF-CC1
TIGR01642182-343  U2AF_lg
COG0265302-392  DegQ
COG0793290-387  CtpA
TIGR01622183-274  SF-CC1
TIGR02860340-386  spore_IV_B
TIGR02037532-568  degP_htrA_DO
PRK1089842-118  PRK10898
TIGR00225521-586  prc
TIGR00225320-383  prc


Ontology Information


   
HPRD ID3719
Molecular ClassCell junction protein
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO