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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23723077 | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR, Western Blotting, Chromatin immunoprecipitation | Up-regulation | - | FOXQ1 as a modulator of TWIST1-mediated metastatic phenotypes and support its potential as a biomarker of metastasis. enhanced expression of FOXQ1 resulted in increased migration and invasion in colorectal cancer cell lines, whereas knockdown studies showed the opposite effect. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[ |
| Chromosome | 6 |
| Location | 6p25 |
| Start | 1312440 |
| End | 1314758 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2319 |
| OMIM ID | 612788 |
| HGNC ID | HGNC:20951 |
| Unigene ID | Hs.591352 |
| Ensembl ID | ENSG00000164379 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_150285.3 |
|---|---|
| Protein Name | forkhead box Q1 |
| Molecular Wt. (Da) | 41395 |
| Protein Sequence | Download Select all |
| Length | 403 |
| Uniprot ID | P25800 |
| Ensembl Protein ID | ENSP00000338207 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 119-197 | FH |
| cl00061 | 119-197 | FH superfamily |
| smart00339 | 119-208 | FH |
| pfam00250 | 119-209 | Fork_head |
| COG5025 | 110-204 | COG5025 |
| COG5025 | 119-204 | COG5025 |
Ontology Information
| HPRD ID | 1087 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.