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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
GSTO1 9446 glutathione S-transferase omega 1  10GSTTLp28, P28 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17376711   2007Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Two-dimensional polyacrylamide gel electrophoresis (2-DE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis,Western blot and/or real-time PCR.Up-regulation-Tiam1 transfection in colorectal cancer cells could upregulate the expression of Fascin-1, heat shock protein 27 (HSP27), high-mobility group box 1 (HMGB1), glutathione S-transferase omega 1 (GSTO1).


Gene Details



NC_000010.10 (106013952..106027222)

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Gene Type protein coding
Gene Family Glutathione S-transferases / Soluble
Description The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]  
Chromosome 10
Location 10q25.1
Start 106013952  
End 106027222  
Strand +  
Gene Sequence

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Length 13271  
OMIM ID 605482   
HGNC ID HGNC:13312   
Unigene ID Hs.190028   
Ensembl ID ENSG00000148834   
PharmGKB ID PA133787054   

mRNA Information


mRNA ID ?NM_001191002.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS53572.1



Protein Information


      
Protein IDNP_001177931.1
Protein Nameglutathione S-transferase omega 1
Molecular Wt. (Da)0
Protein Sequence

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Length 241  
Uniprot IDQ9UPW6
Ensembl Protein ID ENSP00000260926  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SAcetylation2
SPhosphorylation125
KAcetylation152
KAcetylation143
KAcetylation122
KAcetylation148
KAcetylation57
KAcetylation65
SPhosphorylation129
SPhosphorylation213
SPhosphorylation218

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1937EEF1G11745NP_001395.1yeast 2-hybrid16169070   
57562KIAA137717212NP_065853.2yeast 2-hybrid16169070   
84060C7orf6413173NP_115496.2yeast 2-hybrid16169070   


Pathway Information


                        
Pathway Name Pathway ID
Chemical carcinogenesis hsa05204
Drug metabolism - cytochrome P450 hsa00982
Glutathione metabolism hsa00480
Metabolism of xenobiotics by cytochrome P450 hsa00980


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd03184108-229  GST_C_Omega
cl02776108-229  GST_C_family superfamily
cd03055May-94  GST_N_Omega
cl00388May-94  Thioredoxin_like superfamily
pfam1341727-100  GST_N_3
pfam1340931-96  GST_N_2
cd0057024-94  GST_N_family
cd0305927-97  GST_N_SspA
cd0305324-95  GST_N_Phi
cd0305125-94  GST_N_GTT2_like
cd0306026-86  GST_N_Omega_like
cd00299143-206  GST_C_family
cd0305833-97  GST_N_Tau
cd0304933-94  GST_N_3
pfam00043136-210  GST_C
cd03185122-216  GST_C_Tau
cd0305624-93  GST_N_4
cd0304237-94  GST_N_Zeta
cd0304635-98  GST_N_GTT1_like
pfam0279827-95  GST_N
cd0304524-93  GST_N_Delta_Epsilon
cd0303935-93  GST_N_Sigma_like
cd0303831-98  GST_N_etherase_LigE
cd0305732-98  GST_N_Beta
cd10291136-212  GST_C_YfcG_like
pfam14497132-208  GST_C_3
COG069523-75  GrxC
cd03192130-200  GST_C_Sigma_like
cd0304840-98  GST_N_Ure2p_like
pfam0046224-54  Glutaredoxin
cd03210138-219  GST_C_Pi
cd0165924-76  TRX_superfamily
cd03196134-210  GST_C_5
cd0304458-93  GST_N_EF1Bgamma
cd0306132-73  GST_N_CLIC
cd0303725-95  GST_N_GRX2
COG062526-210  GstA
TIGR0126237-174  maiA
PLN0281732-185  PLN02817
PLN0237832-185  PLN02378
PRK0948134-217  sspA
PRK1054240-220  PRK10542
PRK1035733-107  PRK10357
PLN0247332-216  PLN02473
TIGR0086232-158  O-ClC
PRK1511331-116  PRK15113
TIGR0218225-208  GRXB
PLN0239524-97  PLN02395


Ontology Information


   
HPRD ID6408
Molecular ClassEnzyme: Glutathione transferase
Molecular FunctionReceptor signaling complex scaffold activity (GO:0030159)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P78417DB00163Vitamin ESmallMoleculeDrug
P78417DB00143GlutathioneSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO