Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAP4K4 | 9448 | mitogen-activated protein kinase kinase kinase kinase 4 | 2 | HGK, NIK, FLH21957 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25602366 | 2015 | Cell line : SW480 Source : - Sample Type : - No. of Sample : - Stage : - | Dual-luciferase reporter gene assay | Up-regulation | - | miR-194, regulating the MAP4K4/c-Jun/MDM2 signaling pathway, might act as a tumor suppressor and serve as a novel target for CRC prevention and therapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Mitogen-activated protein kinase cascade / Kinase kinase kinase kinases |
| Description | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q11.2-q12 |
| Start | 102314165 |
| End | 102511152 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 196988 |
| OMIM ID | 604666 |
| HGNC ID | HGNC:6866 |
| Unigene ID | Hs.701013 |
| Ensembl ID | ENSG00000071054 |
| PharmGKB ID | PA30612 |
Protein Information
| Protein ID | NP_001229488.1 |
|---|---|
| Protein Name | mitogen-activated protein kinase kinase kinase kinase 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1239 |
| Uniprot ID | Q9UPT9 |
| Ensembl Protein ID | ENSP00000261497 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 706 |
| S | Phosphorylation | 708 |
| S | Phosphorylation | 882 |
| S | Phosphorylation | 886 |
| S | Phosphorylation | 544 |
| S | Phosphorylation | 546 |
| S | Phosphorylation | 720 |
| S | Phosphorylation | 724 |
| S | Phosphorylation | 598 |
| S | Phosphorylation | 600 |
| S | Phosphorylation | 774 |
| S | Phosphorylation | 778 |
| S | Phosphorylation | 770;- |
| S | Phosphorylation | 774;- |
| S | Phosphorylation | 608;- |
| S | Phosphorylation | 612;- |
| S | Phosphorylation | 666;- |
| S | Phosphorylation | 662;- |
| S | Phosphorylation | 716 |
| S | Phosphorylation | 733 |
| S | Phosphorylation | 736 |
| S | Phosphorylation | 554 |
| S | Phosphorylation | 571 |
| S | Phosphorylation | 574 |
| S | Phosphorylation | 608 |
| S | Phosphorylation | 625 |
| S | Phosphorylation | 628 |
| T | Phosphorylation | 704 |
| T | Phosphorylation | 542 |
| T | Phosphorylation | 596 |
| T | Phosphorylation | 996 |
| T | Phosphorylation | 834 |
| T | Phosphorylation | 888 |
| S | Phosphorylation | 721 |
| S | Phosphorylation | 559 |
| S | Phosphorylation | 613 |
| T | Phosphorylation | 988 |
| T | Phosphorylation | 826 |
| T | Phosphorylation | 880 |
| S | Phosphorylation | 994 |
| S | Phosphorylation | 832 |
| S | Phosphorylation | 886 |
| S | Phosphorylation | 949 |
| S | Phosphorylation | 787 |
| S | Phosphorylation | 841 |
| S | Phosphorylation | 755 |
| S | Phosphorylation | 593 |
| S | Phosphorylation | 647 |
| S | Phosphorylation | 636 |
| S | Phosphorylation | 790 |
| S | Phosphorylation | 628 |
| S | Phosphorylation | 682 |
| S | Phosphorylation | 933 |
| S | Phosphorylation | 771 |
| S | Phosphorylation | 825 |
| S | Phosphorylation | 923 |
| S | Phosphorylation | 761 |
| S | Phosphorylation | 815 |
| S | Phosphorylation | 793 |
| S | Phosphorylation | 631 |
| S | Phosphorylation | 685 |
| S | Phosphorylation | 645 |
| T | Phosphorylation | 909 |
| T | Phosphorylation | 747 |
| T | Phosphorylation | 801 |
| S | Phosphorylation | 881 |
| S | Phosphorylation | 719 |
| S | Phosphorylation | 773 |
| T | Phosphorylation | 319 |
| Y | Phosphorylation | 321 |
| T | Phosphorylation | 319 |
| Y | Phosphorylation | 321 |
| T | Phosphorylation | 319 |
| Y | Phosphorylation | 321 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 326 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 326 |
| S | Phosphorylation | 324 |
| S | Phosphorylation | 326 |
| S | Phosphorylation | 936 |
| T | Phosphorylation | 938 |
| S | Phosphorylation | 774 |
| T | Phosphorylation | 776 |
| S | Phosphorylation | 828 |
| T | Phosphorylation | 830 |
| S | Phosphorylation | 726 |
| S | Phosphorylation | 564 |
| S | Phosphorylation | 618 |
| S | Phosphorylation | 643 |
| S | Phosphorylation | 648 |
| S | Phosphorylation | 892 |
| S | Phosphorylation | 730 |
| S | Phosphorylation | 784 |
| S | Phosphorylation | 350 |
| T | Phosphorylation | 351 |
| S | Phosphorylation | 350 |
| T | Phosphorylation | 351 |
| S | Phosphorylation | 350 |
| T | Phosphorylation | 351 |
| T | Phosphorylation | 705 |
| T | Phosphorylation | 543 |
| T | Phosphorylation | 597 |
| S | Phosphorylation | 5 |
| S | Phosphorylation | 5 |
| S | Phosphorylation | 5 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 841 | CASP8 | 3459 | NP_001073594.1 | in vivo | 11002417 |
| 1796 | DOK1 | 4228 | NP_001372.1 | in vivo | 10669731 |
| 2635 | GBP3 | 2683 | NP_060754.2 | in vitro;in vivo;yeast 2-hybrid | 12387898 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vitro;in vivo | 11967148 |
| 4690 | NCK1 | 2740 | NP_006144.1 | in vitro;in vivo | 913 514 410 805 734 |
| 5911 | RAP2A | 1547 | NP_066361.1 | yeast 2-hybrid | 14966141 |
| 5921 | RASA1 | 745 | NP_002881.1 | in vivo | 10669731 |
| 6548 | SLC9A1 | 123 | NP_003038.2 | in vitro;in vivo;yeast 2-hybrid | 11369779 |
| 6885 | MAP3K7 | 4011 | NP_663304.1 | in vitro;in vivo | 10807933 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06636 | 8-289 | STKc_MAP4K4_6_N |
| cl21453 | 8-289 | PKc_like superfamily |
| cd06637 | 18-313 | STKc_TNIK |
| cd06608 | 18-289 | STKc_myosinIII_N_like |
| cd05122 | 24-289 | PKc_STE |
| cd06613 | 24-289 | STKc_MAP4K3_like |
| cd06612 | 21-289 | STKc_MST1_2 |
| cd06609 | 24-290 | STKc_MST3_like |
| smart00036 | 921-1219 | CNH |
| cl02434 | 921-1219 | CNH superfamily |
| cd06638 | 13-289 | STKc_myosinIIIA_N |
| cd06639 | 13-290 | STKc_myosinIIIB_N |
| cd06614 | 24-289 | STKc_PAK |
| cd06611 | 20-302 | STKc_SLK_like |
| cd06646 | 19-289 | STKc_MAP4K5 |
| cd06645 | 13-289 | STKc_MAP4K3 |
| cd06917 | 24-292 | STKc_NAK1_like |
| cd06610 | 25-289 | STKc_OSR1_SPAK |
| pfam00780 | 930-1210 | CNH |
| cd06607 | 24-290 | STKc_TAO |
| cd06642 | 20-308 | STKc_STK25 |
| cd06606 | 25-289 | STKc_MAPKKK |
| cd06644 | 20-299 | STKc_STK10 |
| cd06627 | 25-289 | STKc_Cdc7_like |
| cd06643 | 20-299 | STKc_SLK |
| cd06641 | 20-308 | STKc_MST3 |
| cd06640 | 20-311 | STKc_MST4 |
| cd06623 | 25-290 | PKc_MAPKK_plant_like |
| cd06648 | 20-290 | STKc_PAK_II |
| cd06633 | 14-317 | STKc_TAO3 |
| cd06647 | 17-290 | STKc_PAK_I |
| cd06605 | 25-289 | PKc_MAPKK |
| cd06635 | 3-317 | STKc_TAO1 |
| cd08215 | 25-289 | STKc_Nek |
| cd00180 | 32-287 | PKc |
| cd06631 | 29-289 | STKc_YSK4 |
| cd06634 | 20-317 | STKc_TAO2 |
| cd06632 | 29-289 | STKc_MEKK1_plant |
| cd14014 | 25-284 | STKc_PknB_like |
| cd06656 | 17-290 | STKc_PAK3 |
| cd06654 | 17-290 | STKc_PAK1 |
| cd06625 | 30-289 | STKc_MEKK3_like |
| cd06621 | 23-296 | PKc_Pek1_like |
| cd14003 | 25-288 | STKc_AMPK-like |
| cd06655 | 17-290 | STKc_PAK2 |
| cd06659 | 20-289 | STKc_PAK6 |
| cd05117 | 25-288 | STKc_CAMK |
| cd06617 | 25-289 | PKc_MKK3_6 |
| cd06626 | 31-289 | STKc_MEKK4 |
| cd14007 | 25-290 | STKc_Aurora |
| cd08217 | 25-289 | STKc_Nek2 |
| cd06657 | 20-289 | STKc_PAK4 |
| cd13999 | 31-285 | STKc_MAP3K-like |
| cd06658 | 31-290 | STKc_PAK5 |
| cd06620 | 12-301 | PKc_Byr1_like |
| cd08529 | 25-287 | STKc_FA2-like |
| cd14008 | 32-289 | STKc_LKB1_CaMKK |
| cd05123 | 31-288 | STKc_AGC |
| cd14002 | 25-289 | STKc_STK36 |
| cd06624 | 30-289 | STKc_ASK |
| cd08530 | 25-287 | STKc_CNK2-like |
| cd06628 | 30-289 | STKc_Byr2_like |
| cd06618 | 25-308 | PKc_MKK7 |
| cd14009 | 31-288 | STKc_ATG1_ULK_like |
| cd06652 | 25-289 | STKc_MEKK2 |
| cd05118 | 25-289 | STKc_CMGC |
| cd06616 | 31-291 | PKc_MKK4 |
| cd06622 | 26-308 | PKc_PBS2_like |
| cd06653 | 25-289 | STKc_MEKK3_like_u1 |
| cd14099 | 25-289 | STKc_PLK |
| cd06629 | 29-289 | STKc_Bck1_like |
| cd08216 | 32-304 | PK_STRAD |
| cd06615 | 25-290 | PKc_MEK |
| cd07829 | 25-289 | STKc_CDK_like |
| cd06651 | 29-288 | STKc_MEKK3 |
| cd05579 | 33-291 | STKc_MAST_like |
| cd06619 | 29-290 | PKc_MKK5 |
| cd05581 | 25-288 | STKc_PDK1 |
| cd08223 | 25-289 | STKc_Nek4 |
| cd08224 | 25-285 | STKc_Nek6_7 |
| cd07833 | 25-288 | STKc_CDKL |
| cd07830 | 25-288 | STKc_MAK_like |
| cd14010 | 25-288 | STKc_ULK4 |
| cd14093 | 25-288 | STKc_PhKG |
| cd13983 | 29-289 | STKc_WNK |
| cd08225 | 25-238 | STKc_Nek5 |
| cd08218 | 28-289 | STKc_Nek1 |
| cd08220 | 25-289 | STKc_Nek8 |
| cd00192 | 29-236 | PTKc |
| cd13996 | 25-226 | STKc_EIF2AK |
| cd13985 | 30-284 | STKc_GAK_like |
| cd14131 | 24-288 | PKc_Mps1 |
| cd14098 | 25-288 | STKc_Rad53_Cds1 |
| cd14046 | 25-286 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14137 | 25-288 | STKc_GSK3 |
| cd07840 | 25-288 | STKc_CDK9_like |
| cd13993 | 25-224 | STKc_Pat1_like |
| cd13995 | 31-286 | STKc_MAP3K8 |
| cd14081 | 23-289 | STKc_BRSK1_2 |
| cd06650 | 25-295 | PKc_MEK1 |
| cd08219 | 25-241 | STKc_Nek3 |
| cd14663 | 25-288 | STKc_SnRK3 |
| cd06630 | 29-290 | STKc_MEKK1 |
| cd05611 | 31-232 | STKc_Rim15_like |
| cd14119 | 32-287 | STKc_LKB1 |
| cd14120 | 31-288 | STKc_ULK1_2-like |
| cd05580 | 25-240 | STKc_PKA_like |
| cd14006 | 32-232 | STKc_MLCK-like |
| cd07847 | 25-288 | STKc_CDKL1_4 |
| cd14201 | 29-289 | STKc_ULK2 |
| cd13997 | 25-287 | PKc_Wee1_like |
| cd08221 | 28-289 | STKc_Nek9 |
| cd05573 | 25-235 | STKc_ROCK_NDR_like |
| cd13979 | 29-285 | STKc_Mos |
| cd07846 | 25-288 | STKc_CDKL2_3 |
| cd14075 | 31-232 | STKc_NIM1 |
| cd14202 | 25-289 | STKc_ULK1 |
| cd14181 | 29-288 | STKc_PhKG2 |
| cd14050 | 24-287 | PKc_Myt1 |
| cd14079 | 23-288 | STKc_AMPK_alpha |
| cd14084 | 30-232 | STKc_Chk2 |
| cd07838 | 25-226 | STKc_CDK4_6_like |
| cd14121 | 29-232 | STKc_ULK3 |
| cd06649 | 25-290 | PKc_MEK2 |
| cd14182 | 25-245 | STKc_PhKG1 |
| cd14078 | 23-221 | STKc_MELK |
| cd14073 | 25-232 | STKc_NUAK |
| cd07834 | 25-288 | STKc_MAPK |
| cd08222 | 25-289 | STKc_Nek11 |
| cd14186 | 25-289 | STKc_PLK4 |
| cd05572 | 31-240 | STKc_cGK |
| cd14188 | 29-288 | STKc_PLK2 |
| cd13994 | 31-232 | STKc_HAL4_like |
| cd14069 | 25-232 | STKc_Chk1 |
| cd05578 | 25-232 | STKc_Yank1 |
| cd14166 | 24-289 | STKc_CaMKI_gamma |
| cd14133 | 25-289 | PKc_DYRK_like |
| cd07851 | 24-231 | STKc_p38 |
| cd14210 | 25-289 | PKc_DYRK |
| cd14091 | 25-310 | STKc_RSK_C |
| cd07845 | 25-231 | STKc_CDK10 |
| cd05599 | 25-293 | STKc_NDR_like |
| cd07841 | 25-198 | STKc_CDK7 |
| cd14047 | 25-286 | STKc_EIF2AK2_PKR |
| cd07836 | 25-231 | STKc_Pho85 |
| cd14118 | 69-289 | STKc_CAMKK |
| cd05613 | 25-233 | STKc_MSK1_N |
| cd07839 | 25-233 | STKc_CDK5 |
| cd14189 | 30-288 | STKc_PLK3 |
| cd08228 | 25-233 | STKc_Nek6 |
| cd14062 | 31-232 | STKc_Raf |
| cd14059 | 31-236 | STKc_MAP3K12_13 |
| cd14116 | 25-289 | STKc_Aurora-A |
| cd08528 | 25-232 | STKc_Nek10 |
| cd05601 | 25-232 | STKc_CRIK |
| cd14065 | 31-226 | PKc_LIMK_like |
| cd05570 | 30-299 | STKc_PKC |
| cd05574 | 25-234 | STKc_phototropin_like |
| cd05612 | 25-238 | STKc_PRKX_like |
| cd13986 | 25-286 | STKc_16 |
| cd14060 | 32-217 | STKc_MLTK |
| cd14004 | 25-289 | STKc_PASK |
| cd14094 | 24-311 | STKc_CASK |
| cd14072 | 25-232 | STKc_MARK |
| cd05596 | 15-232 | STKc_ROCK |
| cd05622 | 15-233 | STKc_ROCK1 |
| cd14151 | 21-284 | STKc_B-Raf |
| cd05041 | 29-285 | PTKc_Fes_like |
| cd13998 | 29-227 | STKc_TGFbR-like |
| cd13989 | 32-232 | STKc_IKK |
| cd05621 | 25-233 | STKc_ROCK2 |
| cd14097 | 24-232 | STKc_STK33 |
| cd07835 | 25-231 | STKc_CDK1_CdkB_like |
| cd13987 | 31-232 | STKc_SBK1 |
| cd14005 | 25-287 | STKc_PIM |
| cd08229 | 25-233 | STKc_Nek7 |
| cd14155 | 31-253 | PKc_TESK |
| cd14192 | 28-289 | STKc_MLCK3 |
| cd14053 | 29-227 | STKc_ACVR2 |
| cd14193 | 29-233 | STKc_MLCK4 |
| cd07831 | 32-226 | STKc_MOK |
| cd14095 | 25-232 | STKc_DCKL |
| cd05624 | 25-233 | STKc_MRCK_beta |
| cd14086 | 25-290 | STKc_CaMKII |
| cd05614 | 25-233 | STKc_MSK2_N |
| cd14103 | 31-221 | STKc_MLCK |
| cd14154 | 31-226 | STKc_LIMK |
| cd05597 | 25-232 | STKc_DMPK_like |
| cd14092 | 29-232 | STKc_MSK_C |
| cd14149 | 27-232 | STKc_C-Raf |
| cd14063 | 26-238 | PK_KSR |
| cd14077 | 23-289 | STKc_Kin1_2 |
| cd07880 | 31-231 | STKc_p38gamma |
| cd07865 | 20-226 | STKc_CDK9 |
| cd14061 | 30-232 | STKc_MLK |
| cd14150 | 26-232 | STKc_A-Raf |
| cd14179 | 29-233 | STKc_MSK1_C |
| cd05038 | 32-226 | PTKc_Jak_rpt2 |
| cd05583 | 30-232 | STKc_MSK_N |
| cd07856 | 31-231 | STKc_Sty1_Hog1 |
| cd05584 | 30-291 | STKc_p70S6K |
| cd14187 | 31-233 | STKc_PLK1 |
| cd07832 | 25-231 | STKc_CCRK |
| cd07860 | 24-226 | STKc_CDK2_3 |
| cd14114 | 25-233 | STKc_Twitchin_like |
| cd14083 | 24-235 | STKc_CaMKI |
| cd14080 | 25-221 | STKc_TSSK-like |
| cd14161 | 25-242 | STKc_NUAK2 |
| cd14209 | 25-239 | STKc_PKA |
| cd14074 | 22-289 | STKc_SNRK |
| cd14052 | 25-287 | PTKc_Wee1_fungi |
| cd05608 | 30-233 | STKc_GRK1 |
| cd14167 | 24-235 | STKc_CaMKI_alpha |
| cd07852 | 25-312 | STKc_MAPK15-like |
| cd05604 | 28-239 | STKc_SGK3 |
| cd14056 | 29-238 | STKc_TGFbR_I |
| cd05600 | 25-234 | STKc_Sid2p_like |
| cd14058 | 31-285 | STKc_TAK1 |
| cd08226 | 39-250 | PK_STRAD_beta |
| cd14066 | 31-232 | STKc_IRAK |
| cd14117 | 25-298 | STKc_Aurora-B_like |
| cd14016 | 25-192 | STKc_CK1 |
| cd14221 | 31-226 | STKc_LIMK1 |
| cd14665 | 25-235 | STKc_SnRK2-3 |
| cd05112 | 27-232 | PTKc_Itk |
| cd07861 | 25-231 | STKc_CDK1_euk |
| cd14106 | 29-289 | STKc_DRAK |
| cd05602 | 25-233 | STKc_SGK1 |
| cd14090 | 24-232 | STKc_Mnk |
| cd14036 | 30-284 | STKc_GAK |
| cd07863 | 25-234 | STKc_CDK4 |
| cd07849 | 25-231 | STKc_ERK1_2_like |
| cd05582 | 30-232 | STKc_RSK_N |
| cd05609 | 25-232 | STKc_MAST |
| cd07855 | 25-226 | STKc_ERK5 |
| cd07843 | 25-220 | STKc_CDC2L1 |
| cd14087 | 25-289 | STKc_PSKH1 |
| cd14012 | 69-288 | PK_eIF2AK_GCN2_rpt1 |
| cd14132 | 25-226 | STKc_CK2_alpha |
| cd14055 | 29-205 | STKc_TGFbR2_like |
| cd14185 | 25-233 | STKc_DCKL3 |
| cd14070 | 31-232 | STKc_HUNK |
| smart00750 | 111-289 | KIND |
| cd05617 | 23-306 | STKc_aPKC_zeta |
| cd05623 | 25-233 | STKc_MRCK_alpha |
| cd05595 | 29-251 | STKc_PKB_beta |
| cd05586 | 31-291 | STKc_Sck1_like |
| cd14082 | 29-249 | STKc_PKD |
| cd14197 | 100-233 | STKc_DRAK1 |
| cd05618 | 25-233 | STKc_aPKC_iota |
| cd13978 | 31-221 | STKc_RIP |
| cd14089 | 29-240 | STKc_MAPKAPK |
| cd14198 | 98-289 | STKc_DRAK2 |
| cd14033 | 31-288 | STKc_WNK4 |
| cd07877 | 31-253 | STKc_p38alpha |
| cd14162 | 25-235 | STKc_TSSK4-like |
| cd14171 | 31-242 | STKc_MAPKAPK5 |
| cd14017 | 25-232 | STKc_TTBK |
| cd14212 | 25-231 | PKc_YAK1 |
| cd14168 | 24-235 | STKc_CaMKI_delta |
| cd14194 | 25-233 | STKc_DAPK1 |
| cd08227 | 26-236 | PK_STRAD_alpha |
| cd14142 | 27-239 | STKc_ACVR1_ALK1 |
| cd05575 | 30-232 | STKc_SGK |
| cd07878 | 31-229 | STKc_p38beta |
| cd05053 | 26-232 | PTKc_FGFR |
| cd14001 | 66-284 | PKc_TOPK |
| cd07864 | 25-220 | STKc_CDK12 |
| cd14145 | 12-233 | STKc_MLK1 |
| cd05616 | 25-233 | STKc_cPKC_beta |
| cd14156 | 31-285 | PKc_LIMK_like_unk |
| cd05589 | 25-232 | STKc_PKN |
| cd05067 | 21-226 | PTKc_Lck_Blk |
| cd14037 | 26-288 | STKc_NAK_like |
| cd14190 | 29-233 | STKc_MLCK2 |
| cd05080 | 25-226 | PTKc_Tyk2_rpt2 |
| cd05593 | 25-288 | STKc_PKB_gamma |
| cd05085 | 29-221 | PTKc_Fer |
| cd14031 | 21-288 | STKc_WNK3 |
| cd14165 | 31-235 | STKc_TSSK1_2-like |
| cd05592 | 30-235 | STKc_nPKC_theta_like |
| cd14196 | 24-233 | STKc_DAPK2 |
| cd05577 | 31-232 | STKc_GRK |
| cd05047 | 29-236 | PTKc_Tie |
| cd14102 | 24-289 | STKc_PIM3 |
| cd05590 | 29-233 | STKc_nPKC_eta |
| cd14662 | 25-235 | STKc_SnRK2 |
| cd07844 | 25-231 | STKc_PCTAIRE_like |
| cd05619 | 25-233 | STKc_nPKC_theta |
| cd05571 | 29-291 | STKc_PKB |
| cd14199 | 69-235 | STKc_CaMKK2 |
| cd14141 | 29-227 | STKc_ACVR2a |
| cd05057 | 25-232 | PTKc_EGFR_like |
| cd07837 | 25-231 | STKc_CdkB_plant |
| cd13982 | 29-288 | STKc_IRE1 |
| cd05084 | 29-236 | PTKc_Fes |
| cd05072 | 21-226 | PTKc_Lyn |
| cd14184 | 25-288 | STKc_DCKL2 |
| cd07848 | 25-247 | STKc_CDKL5 |
| cd14134 | 25-229 | PKc_CLK |
| cd13968 | 32-173 | PKc_like |
| cd05603 | 29-233 | STKc_SGK2 |
| cd14222 | 31-226 | STKc_LIMK2 |
| cd14144 | 31-251 | STKc_BMPR1 |
| cd07879 | 31-229 | STKc_p38delta |
| cd07870 | 28-231 | STKc_PFTAIRE2 |
| cd07871 | 31-231 | STKc_PCTAIRE3 |
| cd14071 | 25-232 | STKc_SIK |
| cd13988 | 31-232 | STKc_TBK1 |
| cd07866 | 16-233 | STKc_BUR1 |
| cd13991 | 31-251 | STKc_NIK |
| cd14664 | 31-232 | STK_BAK1_like |
| cd05148 | 25-226 | PTKc_Srm_Brk |
| cd07872 | 28-231 | STKc_PCTAIRE2 |
| cd14158 | 31-233 | STKc_IRAK4 |
| cd05615 | 25-233 | STKc_cPKC_alpha |
| cd14200 | 69-235 | STKc_CaMKK1 |
| cd13992 | 36-282 | PK_GC |
| cd14195 | 25-233 | STKc_DAPK3 |
| cd14191 | 24-233 | STKc_MLCK1 |
| cd05587 | 30-232 | STKc_cPKC |
| cd05594 | 25-288 | STKc_PKB_alpha |
| cd14039 | 31-238 | STKc_IKK_alpha |
| cd14076 | 23-237 | STKc_Kin4 |
| cd14105 | 25-232 | STKc_DAPK |
| cd07873 | 31-231 | STKc_PCTAIRE1 |
| cd05591 | 29-232 | STKc_nPKC_epsilon |
| cd05054 | 27-232 | PTKc_VEGFR |
| cd14019 | 24-288 | STKc_Cdc7 |
| cd14038 | 31-233 | STKc_IKK_beta |
| cd14111 | 21-238 | STKc_SPEG_rpt2 |
| cd14211 | 25-231 | STKc_HIPK |
| cd14085 | 22-315 | STKc_CaMKIV |
| cd14175 | 29-304 | STKc_RSK1_C |
| cd05039 | 26-221 | PTKc_Csk_like |
| cd07858 | 31-220 | STKc_TEY_MAPK |
| cd07862 | 25-231 | STKc_CDK6 |
| cd14147 | 25-232 | STKc_MLK3 |
| cd14148 | 30-232 | STKc_MLK2 |
| cd05088 | 29-236 | PTKc_Tie2 |
| cd05055 | 21-243 | PTKc_PDGFR |
| cd14030 | 31-292 | STKc_WNK1 |
| cd07869 | 22-249 | STKc_PFTAIRE1 |
| cd14163 | 25-289 | STKc_TSSK3-like |
| cd05588 | 30-232 | STKc_aPKC |
| cd14178 | 25-235 | STKc_RSK3_C |
| cd14146 | 30-232 | STKc_MLK4 |
| cd05627 | 25-238 | STKc_NDR2 |
| cd07857 | 25-231 | STKc_MPK1 |
| cd14049 | 25-226 | STKc_EIF2AK1_HRI |
| cd05034 | 32-226 | PTKc_Src_like |
| cd05620 | 29-233 | STKc_nPKC_delta |
| cd05032 | 26-227 | PTKc_InsR_like |
| cd14173 | 29-233 | STKc_Mnk2 |
| cd05607 | 30-235 | STKc_GRK7 |
| cd14203 | 31-226 | PTKc_Src_Fyn_like |
| cd05101 | 31-226 | PTKc_FGFR2 |
| cd14096 | 25-235 | STKc_RCK1-like |
| cd05069 | 31-226 | PTKc_Yes |
| cd14100 | 24-289 | STKc_PIM1 |
| cd14172 | 29-233 | STKc_MAPKAPK3 |
| cd14115 | 31-288 | STKc_Kalirin_C |
| cd14152 | 26-200 | STKc_KSR1 |
| cd05060 | 31-236 | PTKc_Syk_like |
| cd14177 | 24-299 | STKc_RSK4_C |
| cd14176 | 25-306 | STKc_RSK2_C |
| cd05089 | 29-236 | PTKc_Tie1 |
| cd05610 | 25-291 | STKc_MASTL |
| cd14180 | 18-233 | STKc_MSK2_C |
| cd14174 | 29-233 | STKc_Mnk1 |
| cd05630 | 25-233 | STKc_GRK6 |
| cd05628 | 25-238 | STKc_NDR1 |
| cd14054 | 29-200 | STKc_BMPR2_AMHR2 |
| cd05073 | 21-226 | PTKc_Hck |
| cd05033 | 20-252 | PTKc_EphR |
| cd05632 | 25-233 | STKc_GRK5 |
| cd14220 | 31-227 | STKc_BMPR1a |
| cd14107 | 24-223 | STKc_obscurin_rpt1 |
| cd14048 | 25-226 | STKc_EIF2AK3_PERK |
| cd14169 | 24-235 | STKc_CaMKI_beta |
| cd05091 | 12-234 | PTKc_Ror2 |
| cd14183 | 21-291 | STKc_DCKL1 |
| cd14205 | 27-226 | PTKc_Jak2_rpt2 |
| cd14032 | 31-288 | STKc_WNK2_like |
| cd14108 | 25-288 | STKc_SPEG_rpt1 |
| cd05585 | 30-235 | STKc_YPK1_like |
| cd05071 | 31-227 | PTKc_Src |
| cd05082 | 25-226 | PTKc_Csk |
| cd14140 | 29-226 | STKc_ACVR2b |
| cd05111 | 28-238 | PTK_HER3 |
| cd07842 | 24-173 | STKc_CDK8_like |
| cd05098 | 31-309 | PTKc_FGFR1 |
| cd05631 | 25-233 | STKc_GRK4 |
| cd14229 | 25-231 | STKc_HIPK3 |
| cd05079 | 31-244 | PTKc_Jak1_rpt2 |
| cd05606 | 30-232 | STKc_beta_ARK |
| cd14113 | 103-235 | STKc_Trio_C |
| cd05598 | 25-232 | STKc_LATS |
| cd14104 | 25-232 | STKc_Titin |
| cd14207 | 25-232 | PTKc_VEGFR1 |
| cd05063 | 29-251 | PTKc_EphR_A2 |
| cd14143 | 29-227 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05059 | 27-232 | PTKc_Tec_like |
| cd14153 | 26-200 | PK_KSR2 |
| cd05070 | 25-247 | PTKc_Fyn |
| cd05048 | 21-253 | PTKc_Ror |
| cd05081 | 28-226 | PTKc_Jak3_rpt2 |
| cd05045 | 27-245 | PTKc_RET |
| cd05056 | 26-221 | PTKc_FAK |
| cd14219 | 19-227 | STKc_BMPR1b |
| cd13981 | 31-231 | STKc_Bub1_BubR1 |
| cd05099 | 31-226 | PTKc_FGFR4 |
| cd05052 | 31-227 | PTKc_Abl |
| cd14228 | 25-231 | STKc_HIPK1 |
| cd14227 | 25-231 | STKc_HIPK2 |
| cd05068 | 12-226 | PTKc_Frk_like |
| cd14223 | 25-233 | STKc_GRK2 |
| cd05100 | 31-243 | PTKc_FGFR3 |
| cd14170 | 29-289 | STKc_MAPKAPK2 |
| cd14000 | 32-283 | STKc_LRRK |
| cd05083 | 27-221 | PTKc_Chk |
| cd07854 | 31-245 | STKc_MAPK4_6 |
| cd05633 | 25-233 | STKc_GRK3 |
| cd14164 | 25-232 | STKc_TSSK6-like |
| cd14064 | 31-241 | PKc_TNNI3K |
| cd14226 | 25-231 | PKc_DYRK1 |
| cd14112 | 21-289 | STKc_Unc-89_rpt2 |
| cd07850 | 30-229 | STKc_JNK |
| cd05090 | 21-253 | PTKc_Ror1 |
| cd14225 | 25-231 | PKc_DYRK4 |
| cd05108 | 25-232 | PTKc_EGFR |
| cd05061 | 27-253 | PTKc_InsR |
| cd05605 | 99-232 | STKc_GRK4_like |
| cd05065 | 29-251 | PTKc_EphR_B |
| cd05103 | 21-232 | PTKc_VEGFR2 |
| cd14020 | 69-229 | STKc_KIS |
| cd13977 | 25-228 | STKc_PDIK1L |
| cd05629 | 25-234 | STKc_NDR_like_fungal |
| cd14136 | 133-229 | STKc_SRPK |
| cd05037 | 32-242 | PTK_Jak_rpt1 |
| cd05049 | 27-226 | PTKc_Trk |
| cd07876 | 72-230 | STKc_JNK2 |
| cd05042 | 31-253 | PTKc_Aatyk |
| cd07859 | 25-231 | STKc_TDY_MAPK |
| cd07874 | 72-226 | STKc_JNK3 |
| cd05040 | 29-226 | PTKc_Ack_like |
| cd05102 | 127-232 | PTKc_VEGFR3 |
| cd14135 | 25-229 | STKc_PRP4 |
| cd14013 | 83-227 | STKc_SNT7_plant |
| cd14101 | 30-290 | STKc_PIM2 |
| cd14110 | 34-233 | STKc_obscurin_rpt2 |
| cd05626 | 24-233 | STKc_LATS2 |
| cd05625 | 24-239 | STKc_LATS1 |
| cd05058 | 29-238 | PTKc_Met_Ron |
| cd13990 | 27-232 | STKc_TLK |
| cd05043 | 25-284 | PTK_Ryk |
| cd07875 | 72-229 | STKc_JNK1 |
| cd05109 | 28-232 | PTKc_HER2 |
| cd13975 | 31-221 | PKc_Dusty |
| cd05110 | 28-242 | PTKc_HER4 |
| cd05087 | 31-234 | PTKc_Aatyk1 |
| cd14088 | 25-235 | STKc_CaMK_like |
| cd05046 | 30-226 | PTK_CCK4 |
| cd14068 | 32-221 | STKc_LRRK2 |
| cd05086 | 28-230 | PTKc_Aatyk2 |
| cd05115 | 99-248 | PTKc_Zap-70 |
| cd14025 | 29-214 | STKc_RIP4_like |
| cd14043 | 79-251 | PK_GC-2D |
| cd05107 | 134-284 | PTKc_PDGFR_beta |
| cd14206 | 31-232 | PTKc_Aatyk3 |
| cd14051 | 25-287 | PTKc_Wee1 |
| cd05050 | 133-226 | PTKc_Musk |
| cd05075 | 136-227 | PTKc_Axl |
| cd05078 | 29-242 | PTK_Jak2_rpt1 |
| cd07853 | 24-226 | STKc_NLK |
| cd05066 | 29-236 | PTKc_EphR_A |
| cd14067 | 101-240 | STKc_LRRK1 |
| cd05074 | 25-232 | PTKc_Tyro3 |
| cd05105 | 136-226 | PTKc_PDGFR_alpha |
| cd07867 | 31-231 | STKc_CDC2L6 |
| cd14224 | 25-231 | PKc_DYRK2_3 |
| smart00220 | 25-289 | S_TKc |
| pfam00069 | 25-289 | Pkinase |
| COG0515 | 25-307 | SPS1 |
| pfam07714 | 25-253 | Pkinase_Tyr |
| smart00221 | 26-285 | STYKc |
| smart00219 | 26-285 | TyrKc |
| PLN00034 | 26-297 | PLN00034 |
| PTZ00263 | 25-240 | PTZ00263 |
| PTZ00283 | 13-226 | PTZ00283 |
| PTZ00266 | 25-291 | PTZ00266 |
| PTZ00267 | 79-290 | PTZ00267 |
| PLN00009 | 25-231 | PLN00009 |
| PTZ00036 | 4-231 | PTZ00036 |
| PTZ00024 | 31-231 | PTZ00024 |
| PHA03209 | 133-226 | PHA03209 |
| PTZ00426 | 25-239 | PTZ00426 |
| PHA03212 | 133-229 | PHA03212 |
| PHA03390 | 33-238 | pk1 |
| PHA03207 | 130-227 | PHA03207 |
| PLN03225 | 82-227 | PLN03225 |
| PHA03210 | 133-226 | PHA03210 |
| COG5422 | 921-1206 | ROM1 |
| TIGR03903 | 136-231 | TOMM_kin_cyc |
Ontology Information
| HPRD ID | 9762 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.