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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CD36 | 948 | CD36 molecule (thrombospondin receptor) | 7 | SCARB3, GPIV, FAT, GP4, GP3B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9863008 | 1999 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 65 Stage : - | - | Up-regulation | - | CD36 expression which decreased stromal vascularisation is correlated with better prognosis of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014] |
| Chromosome | 7 |
| Location | 7q11.2 |
| Start | 80231504 |
| End | 80308593 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 77090 |
| OMIM ID | 173510 |
| HGNC ID | HGNC:1663 |
| Unigene ID | Hs.120949 |
| Ensembl ID | ENSG00000135218 |
| PharmGKB ID | PA26212 |
mRNA Information
| mRNA ID | NM_001001547.2 |
|---|---|
| Exon | join(1..192,43901..43994,44465..44673,54353..54513, 58876..59023,60803..60982,62219..62310,64256..64302, 67766..67835,68790..68977,69735..69853,70583..70656, 71168..71222,71796..72233) | mRNA Sequence | Download Select all |
| Length | 2069 |
Protein Information
| Protein ID | NP_001001547.1 |
|---|---|
| Protein Name | CD36 molecule (thrombospondin receptor) |
| Molecular Wt. (Da) | 52922 |
| Protein Sequence | Download Select all |
| Length | 472 |
| Uniprot ID | Q16236 |
| Ensembl Protein ID | ENSP00000380252 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 3 |
| C | Palmitoylation | 464 |
| C | Palmitoylation | 466 |
| C | Palmitoylation | 7 |
| C | Palmitoylation | 464 |
| C | Palmitoylation | 466 |
| C | Palmitoylation | 7 |
| C | Palmitoylation | 464 |
| C | Palmitoylation | 466 |
| C | Palmitoylation | 7 |
| T | Phosphorylation | 92 |
| T | Dephosphorylation | 92 |
| T | Phosphorylation | 92 |
| T | Dephosphorylation | 92 |
| T | Phosphorylation | 92 |
| T | Dephosphorylation | 92 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 928 | CD9 | 880 | NP_001760.1 | in vivo | 11238109 |
| 1277 | COL1A1 | 362 | NP_000079.2 | in vitro | 2468670 |
| 1278 | COL1A2 | 363 | NP_000080.2 | in vitro | 10772928 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 7521304 |
| 3655 | ITGA6 | 945 | NP_001073286.1 | in vivo | 11238109 |
| 3688 | ITGB1 | 628 | NP_391987.1 | in vivo | 11238109 |
| 3690 | ITGB3 | 1428 | NP_000203.2 | in vivo | 11238109 |
| 4067 | LYN | 1301 | NP_002341.1 | in vivo | 1715582 |
| 7525 | YES1 | 1285 | NP_005424.1 | in vivo | 7521304 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| ECM-receptor interaction | hsa04512 |
| Fat digestion and absorption | hsa04975 |
| Hematopoietic cell lineage | hsa04640 |
| Insulin resistance | hsa04931 |
| Malaria | hsa05144 |
| Phagosome | hsa04145 |
| PPAR signaling pathway | hsa03320 |
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 1238 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.