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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ACY1 95 aminoacylase 1  3- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21843667   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : TNM Stage III,IV

 Laser capture microdissection and 2D difference gel electrophoresis (2D-DIGE),Global protein expression analysis,western blotting and immunohistochemistryUp-regulation--

23317546   2013Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 120

Stage : TNM stage III,IV

Immunohistochemistry,tissue microarraysUp-regulation- ACY1 as a clinically useful prognostic marker and a potential drug target for CRC would seem worthwhile.


Gene Details



NC_000003.11 (52017300..52023218)

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Gene Type protein coding
Gene Family -
Description This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]  
Chromosome 3
Location 3p21.2
Start 52017300  
End 52023218  
Strand +  
Gene Sequence

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Length 5919  
OMIM ID 104620   
HGNC ID HGNC:177   
Unigene ID Hs.334707   
Ensembl ID ENSG00000243989   
PharmGKB ID PA24497   

mRNA Information


mRNA ID NM_000666.2
Exon join(1..306,764..875,1924..1988,2078..2182,2569..2663, 2972..3048,3132..3221,3322..3378,3705..3778,3864..3913, 4026..4170,4273..4341,5241..5320,5483..5543,5628..5919)  
mRNA Sequence

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Length 1678  



CDS Information


   
Location325..1551
CDS Sequence

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CCDS ID CCDS2844.1



Protein Information


      
Protein IDNP_000657.1
Protein Nameaminoacylase 1
Molecular Wt. (Da)45754
Protein Sequence

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Length 408  
Uniprot IDQ13257
Ensembl Protein ID ENSP00000296509  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
7265TTC111881NP_003305.1yeast 2-hybrid16189514   


Pathway Information


                        
Pathway Name Pathway ID
2-Oxocarboxylic acid metabolism hsa01210
Arginine biosynthesis hsa00220
Biosynthesis of amino acids hsa01230
Metabolic pathways hsa01100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd056469-399  M20_AcylaseI_like
cl148769-399  Zinc_peptidase_like superfamily
cd0567513-395  M20_yscS_like
cd0865915-395  M20_ArgE_DapE_like
cd0567462-395  M20_yscS
cd0801113-395  M20_ArgE_DapE_like6
cd0389574-378  M20_ArgE_DapE_like2
cd0389475-307  M20_ArgE
cd0388533-365  M20_CPDG2
cd0387315-176  Zinc_peptidase_like
cd0269775-398  M20_like
cd0389113-395  M20_DapE_proteobac
cd0565062-359  M20_ArgE_DapE_like1
cd0565233-308  M20_ArgE_DapE_like_fungal
cd0565315-398  M20_ArgE_LysK
cd0388817-311  M20_PepV
cd0565174-395  M20_ArgE_DapE_like5
cd0389622-360  M20_PAAh_like
cd0801310-279  M20_ArgE_DapE_like3
cd0564775-395  M20_DapE_actinobac
pfam07687188-302  M20_dimer
cd0564947-306  M20_ArgE_DapE_like4
PRK0859637-150  PRK08596
cd0568018-398  M20_dipept_like_3
cd0568112-282  M20_dipept_like_4
cd0801246-293  M20_ArgE-related
cd0389317-328  M20_Dipept_like
PRK0790721-166  PRK07907
cd0567613-150  M20_dipept_like_CNDP
cd0565475-155  M20_ArgE_RocB
cd05672145-305  M20_ACY1L2_like
TIGR018801-401  Ac-peptdase-euk
pfam0154676-395  Peptidase_M20
COG062413-400  ArgE
PRK0826220-400  PRK08262
TIGR0191013-364  DapE-ArgE
PRK0790613-395  PRK07906
PRK0865112-400  PRK08651
PRK0913315-399  PRK09133
TIGR0189275-364  AcOrn-deacetyl
PRK0683762-380  PRK06837
PRK0691574-364  PRK06915
PRK1301313-259  PRK13013
PRK0752275-320  PRK07522
TIGR0124612-395  dapE_proteo
PRK0858880-396  PRK08588
PRK1398379-359  PRK13983
TIGR0190068-395  dapE-gram_pos
PRK0865275-366  PRK08652
PRK0873775-395  PRK08737
PRK1300910-395  PRK13009
PRK1300775-395  PRK13007
TIGR0188720-150  dipeptidaselike
PRK1300447-249  PRK13004
PRK0511175-360  PRK05111
PRK0720580-148  PRK07205
TIGR0352618-249  selenium_YgeY
PRK0046615-278  PRK00466
PRK0820117-161  PRK08201
PRK0855475-157  PRK08554
PRK0613336-291  PRK06133
PRK0644674-176  PRK06446
PRK0910415-186  PRK09104
PRK0731880-150  PRK07318
TIGR01891122-384  amidohydrolases
TIGR0188680-163  dipeptidase
COG1473124-395  AbgB
PRK0747342-207  PRK07473
PRK0615617-161  PRK06156
PRK09290193-315  PRK09290
PRK1289029-326  PRK12890


Ontology Information


   
HPRD ID3221
Molecular ClassEnzyme: Hydrolase
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessSignal transduction (GO:0007165); Regulation of gene expression, epigenetic (GO:0040029)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q03154DB00128L-Aspartic AcidSmallMoleculeDrug
Q03154DB06151AcetylcysteineSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO