Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAGED1 | 9500 | melanoma antigen family D, 1 | X | NRAGE, DLXIN-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22935435 | 2012 | Cell line : - Source : Sun Yat-sen University Cancer Center Sample Type : CRC tumor and normal tissue No. of Sample : 285 paraffin-embedded, archived CRC primary samples Stage : - | Real time RT-PCR, Western blotting, immunohistochemistry | Down-regulation | - | MAGED1 may serve as a novel prognostic biomarker of human colorectal cancer. MAGED1 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues and was associated with clinical stage (p? |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene |
| Chromosome | X |
| Location | Xp11.23 |
| Start | 51803059 |
| End | 51902354 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 99296 |
| OMIM ID | 300224 |
| HGNC ID | HGNC:6813 |
| Unigene ID | Hs.5258 |
| Ensembl ID | ENSG00000179222 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001005332.1 |
|---|---|
| Exon | join(1..59,91211..91291,91995..92702,93351..94019, 94150..94213,94489..94568,94737..94828,95056..95135, 95227..95269,95523..95585,97124..97238,98495..98880, 99088..99296) | mRNA Sequence | Download Select all |
| Length | 2665 |
CDS Information
| Location | join(91247..91291,91569..91736,91995..92702,93351..94019, 94150..94213,94489..94568,94737..94828,95056..95135, 95227..95269,95523..95585,97124..97238,98495..98872) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS35279.1 |
Protein Information
| Protein ID | NP_001005332.1 |
|---|---|
| Protein Name | melanoma antigen family D, 1 |
| Molecular Wt. (Da) | 86030 |
| Protein Sequence | Download Select all |
| Length | 778 |
| Uniprot ID | P49441 |
| Ensembl Protein ID | ENSP00000325423 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 148;- |
| Y | Phosphorylation | 92;- |
| Y | Phosphorylation | 92;- |
| Y | Phosphorylation | 148;- |
| Y | Phosphorylation | 92;- |
| Y | Phosphorylation | 92;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 331 | XIAP | 2094 | NP_001158.2 | in vitro;in vivo;yeast 2-hybrid | 11546791 |
| 4488 | MSX2 | 421 | NP_002440.2 | in vivo | 1 195 985 111 084 030 |
| 4804 | NGFR | 1197 | NP_002498.1 | in vitro;in vivo;yeast 2-hybrid | 10985348 |
| 51547 | SIRT7 | 12094 | NP_057622.1 | yeast 2-hybrid | 16169070 |
| 51660 | BRP44L | 7091 | NP_057182.1 | yeast 2-hybrid | 16169070 |
| 54715 | - | 16091 | NP_665898.1 | yeast 2-hybrid | 16713569 |
| 64582 | GPR135 | 16263 | NP_072093.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Neurotrophin signaling pathway | hsa04722 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01454 | 478-647 | MAGE |
| cl03220 | 478-647 | MAGE superfamily |
| PRK07003 | 39-334 | PRK07003 |
| TIGR01628 | 309-548 | PABP-1234 |
| PRK12323 | 261-469 | PRK12323 |
| PHA03247 | 39-459 | PHA03247 |
| PRK07764 | 265-390 | PRK07764 |
| PRK07764 | 37-467 | PRK07764 |
| PRK07764 | 32-397 | PRK07764 |
| PHA03247 | 267-465 | PHA03247 |
| PRK10263 | 268-396 | PRK10263 |
| PRK10263 | 325-469 | PRK10263 |
| pfam03154 | 271-464 | Atrophin-1 |
| PLN03209 | 45-200 | PLN03209 |
| PRK14965 | 257-337 | PRK14965 |
Ontology Information
| HPRD ID | 3734 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Translation regulator activity (GO:0045182) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.