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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAMTS1 | 9510 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 21 | C3-C5, METH1, KIAA1346 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17167179 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : CRC tumors 198, normal tissues 44. Stage : - | Methylation-specific PCR, bisulphite sequencing, and quantitative gene expression analysis. | Methylation | - | Three genes with cancer-specific hypermethylation in colorectal tumors, ADAMTS1, CRABP1, and NR3C1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidases with thrombospondin type 1 motif |
| Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] |
| Chromosome | 21 |
| Location | 21q21.3 |
| Start | 28208606 |
| End | 28217728 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9123 |
| OMIM ID | 605174 |
| HGNC ID | HGNC:217 |
| Unigene ID | Hs.643357 |
| Ensembl ID | ENSG00000154734 |
| PharmGKB ID | PA24536 |
Protein Information
| Protein ID | NP_008919.3 |
|---|---|
| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 967 |
| Uniprot ID | Q6UUV9 |
| Ensembl Protein ID | ENSP00000323332 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| F | Proteolytic Cleavage | 253 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vivo | 10373500 |
| 176 | ACAN | 1123 | NP_037359.3 | in vitro | 12054629 |
| 1462 | VCAN | 340 | NP_004376.2 | in vitro;in vivo | 1 127 855 912 907 680 |
| 7422 | VEGFA | 1889 | NP_001020537.2 | in vitro;in vivo | 12716911 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04273 | 258-463 | ZnMc_ADAMTS_like |
| cl00064 | 258-463 | ZnMc superfamily |
| pfam05986 | 725-842 | ADAM_spacer1 |
| cl20316 | 725-842 | ADAM_spacer1 superfamily |
| cd04267 | 258-456 | ZnMc_ADAM_like |
| pfam01562 | 59-167 | Pep_M12B_propep |
| cl03265 | 59-167 | Pep_M12B_propep superfamily |
| cd04269 | 258-465 | ZnMc_adamalysin_II_like |
| smart00608 | 468-548 | ACR |
| cl15456 | 468-548 | ADAM_CR superfamily |
| smart00209 | 562-614 | TSP1 |
| cl15278 | 562-614 | TSP_1 superfamily |
| cd00203 | 351-455 | ZnMc |
| cd04272 | 259-463 | ZnMc_salivary_gland_MPs |
| pfam13582 | 301-412 | Reprolysin_3 |
| pfam13688 | 256-454 | Reprolysin_5 |
| pfam00090 | 565-613 | TSP_1 |
| pfam13583 | 264-451 | Reprolysin_4 |
| smart00209 | 858-910 | TSP1 |
| cl15278 | 858-910 | TSP_1 superfamily |
| smart00209 | 912-967 | TSP1 |
| cl15278 | 912-967 | TSP_1 superfamily |
| pfam00090 | 915-966 | TSP_1 |
| cd04270 | 305-471 | ZnMc_TACE_like |
| pfam13574 | 329-456 | Reprolysin_2 |
| pfam01421 | 258-467 | Reprolysin |
| PTZ00441 | 909-966 | PTZ00441 |
Ontology Information
| HPRD ID | 6836 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Deacetylase activity (GO:0019213) |
| Biological Process | Gene silencing (GO:0016458) |
Drug Information
No matching records could be found.