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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26398009 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and cell lines . No. of Sample : - Stage : - | real time RT-PCR,western blotting,methylthiazol tetrazolium assay, cell invasion assay, and wound healing assay,Luciferase reporter assays | Up-regulation | - | These findings demonstrate that miR?18a exhibits a protective role in CRC via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011] |
| Chromosome | 6 |
| Location | 6q22.1-q22 |
| Start | 134273308 |
| End | 134308638 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 35331 |
| OMIM ID | 605521 |
| HGNC ID | HGNC:11589 |
| Unigene ID | Hs.486507 |
| Ensembl ID | ENSG00000028839 |
| PharmGKB ID | PA36353 |
Protein Information
| Protein ID | NP_001240605.1 |
|---|---|
| Protein Name | TBP-like 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 186 |
| Uniprot ID | Q9UPY3 |
| Ensembl Protein ID | ENSP00000343745 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2957 | GTF2A1 | 2748 | NP_056943.1 | in vivo | 10570139 |
| 2958 | GTF2A2 | 2747 | NP_004483.1 | in vivo | 10570139 |
| 2959 | GTF2B | 8928 | NP_001505.1 | in vitro | 10220372 |
| 10226 | PLIN3 | 4080 | NP_005808.3 | yeast 2-hybrid | 16169070 |
| 11021 | RAB35 | 5010 | NP_006852.1 | yeast 2-hybrid | 16169070 |
| 51135 | IRAK4 | 6051 | NP_057207.2 | yeast 2-hybrid | 16169070 |
| 54978 | C2orf18 | 12808 | NP_060347.2 | yeast 2-hybrid | 16169070 |
| 55037 | PTCD3 | 8631 | NP_060422.4 | yeast 2-hybrid | 16169070 |
| 55324 | ABCF3 | 12404 | NP_060828.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Basal transcription factors | hsa03022 |
| Epstein-Barr virus infection | hsa05169 |
| Herpes simplex infection | hsa05168 |
| HTLV-I infection | hsa05166 |
| Huntington's disease | hsa05016 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04517 | 9-180 | TLF |
| cl08263 | 9-180 | TBP_TLF superfamily |
| cd00652 | 10-180 | TBP_TLF |
| cd04516 | 13-176 | TBP_eukaryotes |
| pfam00352 | Sep-92 | TBP |
| pfam00352 | 97-182 | TBP |
| cd04518 | 13-175 | TBP_archaea |
| cd04518 | Jan-91 | TBP_archaea |
| PLN00062 | 13-183 | PLN00062 |
| COG2101 | 5-176 | SPT15 |
| PRK00394 | 11-175 | PRK00394 |
| COG2101 | Oct-92 | SPT15 |
| PRK00394 | Oct-92 | PRK00394 |
Ontology Information
| HPRD ID | 8381 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Deacetylase activity (GO:0019213) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.