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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
H2AFY 9555 H2A histone family, member Y  5H2A.y; H2A/y; H2AFJ; mH2A1; H2AF12M; MACROH2A1.1; macroH2A1.2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysis Unknown--

22589551   2012Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and normal tissue

No. of Sample : -

Stage : TNM Stage II

Chromatin immunoprecipitation,Up-regulation-Macrohistone 2A1 (H2AFY; mH2A1) was found to interact with HER-2 in cancer cells that overexpress HER-2.

Inhibition of HER-2 kinase activity diminished mH2A1 expression and mH2A1.2-induced ERBB2 transcription in cancer cells.


Gene Details



Chromosome: 5; NC_000005.9 (134670071..134735577, complement)

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Gene Type protein coding
Gene Family Histones / Replication-independent
Description Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5q31.1
Start 135334381  
End 135400147  
Strand +  
Gene Sequence

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Length 65767  
OMIM ID 610054   
HGNC ID HGNC:4740   
Unigene ID Hs.420272   
Ensembl ID ENSG00000113648   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001277348.1
Exon complement(join(<55468..56993,62135..62217))  
mRNA Sequence

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Length 2109  



CDS Information


   
Locationcomplement(join(<56682..56993,62135..62217))
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001035248.1
Protein NameH2A histone family, member Y
Molecular Wt. (Da)39358
Protein Sequence

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Length 371  
Uniprot IDP21709
Ensembl Protein ID ENSP00000275815  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KUbiquitination116
KMethylation18
KMethylation123
TPhosphorylation129
KMethylation239
KUbiquitination116
KMethylation18
KMethylation123
TPhosphorylation129
KMethylation238
KMethylation238
TPhosphorylation129
KMethylation123
KMethylation18
KUbiquitination116
KUbiquitination116
KMethylation18
KMethylation123
TPhosphorylation129
KMethylation236
TPhosphorylation178;-
TPhosphorylation177;-
TPhosphorylation178;-
TPhosphorylation177;-
SPhosphorylation170
SPhosphorylation173
SPhosphorylation169
SPhosphorylation172
SPhosphorylation170
SPhosphorylation173
SPhosphorylation169
SPhosphorylation172
TPhosphorylation174
TPhosphorylation173
TPhosphorylation174
TPhosphorylation173
TPhosphorylation175
TPhosphorylation174
TPhosphorylation175
TPhosphorylation174
SPhosphorylation138
SPhosphorylation140
SPhosphorylation138
SPhosphorylation140
SPhosphorylation138
SPhosphorylation140
SPhosphorylation138
SPhosphorylation140

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
142PARP11435NP_001609.2in vitro17158748   


Pathway Information


            
Pathway Name Pathway ID
Alcoholism hsa05034
Systemic lupus erythematosus hsa05322


Structure Information


PDB ID1QYM
Resolution2.8
MethodX-RAY DIFFRACTION
Chains A  
Molecule 26S proteasome non-ATPase regulatory subunit 10  
Model View



Domain Information




ID Location Description
cd02904178-364  Macro_H2A_like
cl00019178-364  Macro superfamily
cd000745-117  H2A
cl000745-117  H2A superfamily
smart0041414-119  H2A
COG52624-128  HTA1
PRK00431210-368  PRK00431
PLN001542-116  PLN00154
PTZ002524-121  PTZ00252
pfam01661216-330  Macro
cd02907207-362  Macro_Af1521_BAL_like
cd02908196-362  Macro_Appr_pase_like
smart00506206-330  A1pp
cd02749196-334  Macro
pfam0012515-88  Histone
PRK04143195-362  PRK04143
cd02906196-334  Macro_1
COG2110210-357  YmdB
cd03330206-335  Macro_2
cd02903211-337  Macro_BAL_like
cd02905196-334  Macro_GDAP2_like
PLN00155Jan-56  PLN00155
COG524723-103  BUR6
cd02901235-333  Macro_Poa1p_like
PTZ000174-126  PTZ00017
PLN001571-123  PLN00157
PLN001562-123  PLN00156
PLN001531-126  PLN00153


Ontology Information


   
HPRD ID3721
Molecular ClassDNA binding protein
Molecular FunctionTransmembrane receptor protein tyrosine kinase activity (GO:0004714)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO