Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHD1L | 9557 | chromodomain helicase DNA binding protein 1-like | 1 | ALC1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23746766 | 2013 | Cell line : SW1116 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 86 Stage : - | FISH, real-time RT-PCR and immunohistochemistry,flow cytometry | Up-regulation | - | CHD1L is the target oncogene within the 1q21 amplicon and plays a pivotal role in CRC pathogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012] |
| Chromosome | 1 |
| Location | 1q21.1 |
| Start | 146714291 |
| End | 146767447 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 53157 |
| OMIM ID | 613039 |
| HGNC ID | HGNC:1916 |
| Unigene ID | Hs.191164 |
| Ensembl ID | ENSG00000131778 |
| PharmGKB ID | PA26452 |
Protein Information
| Protein ID | NP_001243265.1 |
|---|---|
| Protein Name | chromodomain helicase DNA binding protein 1-like |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 897 |
| Uniprot ID | Q96EB6 |
| Ensembl Protein ID | ENSP00000212015 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 636 |
| S | Phosphorylation | 628 |
| T | Phosphorylation | 629 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03331 | 716-866 | Macro_Poa1p_like_SNF2 |
| cl00019 | 716-866 | Macro superfamily |
| cd00079 | 346-467 | HELICc |
| cl21455 | 346-467 | P-loop_NTPase superfamily |
| cd00046 | 65-205 | DEXDc |
| cl21455 | 65-205 | P-loop_NTPase superfamily |
| cd02901 | 717-866 | Macro_Poa1p_like |
| cd02749 | 716-864 | Macro |
| smart00490 | 377-459 | HELICc |
| pfam00271 | 381-459 | Helicase_C |
| pfam00270 | 74-208 | DEAD |
| pfam06936 | 628-695 | Selenoprotein_S |
| cl06134 | 628-695 | Selenoprotein_S superfamily |
| pfam09805 | 630-715 | Nop25 |
| cl23601 | 630-715 | Nop25 superfamily |
| pfam00176 | 49-328 | SNF2_N |
| PLN03142 | 46-699 | PLN03142 |
| COG0553 | 43-496 | HepA |
| smart00487 | 41-230 | DEXDc |
| COG1061 | 46-526 | SSL2 |
| pfam11496 | 281-478 | HDA2-3 |
| TIGR04095 | 44-206 | dnd_restrict_1 |
| COG1204 | 74-179 | BRR2 |
| pfam13904 | 578-683 | DUF4207 |
| pfam02029 | 576-672 | Caldesmon |
| COG1199 | 148-387 | DinG |
Ontology Information
| HPRD ID | 4260 |
|---|---|
| Molecular Class | DNA binding protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.